Results 31 to 40 of about 20,751 (192)

A cyclodextrin-based nanoformulation achieves co-delivery of ginsenoside Rg3 and quercetin for chemo-immunotherapy in colorectal cancer

Acta Pharmaceutica Sinica B, 2021
The immune checkpoint blockade therapy has profoundly revolutionized the field of cancer immunotherapy. However, despite great promise for a variety of cancers, the efficacy of immune checkpoint inhibitors is still low in colorectal cancer (CRC). This is
Dandan Sun, Yifang Zou, Liu Song, Shulan Han, Hao Yang, Dinh-Toi Chu, Yun Dai, Jie Ma, C. O’Driscoll, Zhuo Yu, Jianfeng Guo   +10 more
semanticscholar   +1 more source

Ginsenoside Rg3 inhibits the biological activity of SGC‐7901 [PDF]

Food Science & Nutrition, 2020
AbstractAimTo explore the suppressive effects of ginsenoside Rg3 on the biological activities of gastric cancer and the mechanisms responsible therein, by conducting an in vitro study.Materials and MethodsSGC‐7901 gastric cancer cells were divided into NC, DMSO, Gin‐Low (10 mg/L), Gin‐Middle (20 mg/L), and Gin‐High (40 mg/L) groups.
Qing Yang, Ning Cai, Daobiao Che, Xing Chen, Dongliang Wang   +4 more
openaire   +3 more sources

Polymer-Based Wound Dressings Loaded with Ginsenoside Rg3

Molecules, 2023
The skin, the largest organ in the human body, mainly plays a protective role. Once damaged, it can lead to acute or chronic wounds. Wound healing involves a series of complex physiological processes that require ideal wound dressings to promote it.
Jiali Yang, Lifeng Zhang, Xiaojuan Peng, Shuai Zhang, Shuwen Sun, Qiteng Ding, Chuanbo Ding, Wencong Liu   +7 more
openaire   +3 more sources

Ginsenoside Rg3 increases gemcitabine sensitivity of pancreatic adenocarcinoma via reducing ZFP91 mediated TSPYL2 destabilization

Journal of Ginseng Research, 2022
Background: Ginsenoside Rg3 and gemcitabine have mutual enhancing antitumor effects. However, the underlying mechanisms are not clear. This study explored the influence of ginsenoside Rg3 on Zinc finger protein 91 homolog (ZFP91) expression in pancreatic
Haixia Pan, Linhan Yang, Hansong Bai, Jing Luo, Ying Deng   +4 more
doaj   +1 more source

Co-treatment with Ginsenoside 20(S)-Rg3 and Curcumin increases Radiosensitivity of MDA-MB-231 Cancer Cell Line [PDF]

Iranian Journal of Medical Sciences, 2021
Background: Breast cancer is the second most common cancer in women worldwide. Developing drugs increase the radiosensitivity effect of tumoral tissue, while protecting normal tissues has gained much attention.
Vahid Changizi, Vahideh Gharekhani, Elaheh Motavaseli   +2 more
doaj   +1 more source

Pharmacokinetic Profiling of Ginsenosides, Rb1, Rd, and Rg3, in Mice with Antibiotic-Induced Gut Microbiota Alterations: Implications for Variability in the Therapeutic Efficacy of Red Ginseng Extracts

Foods, 2023
Ginsenoside Rg3 is reported to contribute to the traditionally known diverse effects of red ginseng extracts. Significant individual variations in the therapeutic efficacy of red ginseng extracts have been reported.
Jeon-Kyung Kim, Min Sun Choi, Hee-Seo Park, Kyung Hwa Kee, Dong-Hyun Kim, Hye Hyun Yoo   +5 more
doaj   +1 more source

Ginsenoside Rg3 attenuates angiotensin II-induced myocardial hypertrophy through repressing NLRP3 inflammasome and oxidative stress via modulating SIRT1/NF-κB pathway.

International Immunopharmacology, 2021
BACKGROUND Ginsenoside Rg3 (Rg3), one of the most potent components extracted from the roots of the traditional Chinese herb Panax ginseng, has prominent roles in anti-tumor and anti-inflammation.
Bei Ren, Jin-ping Feng, N. Yang, Yujun Guo, Cheng Chen, Qin Qin   +5 more
semanticscholar   +1 more source

Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches

Science Advances, 2022
Limited circulating tumor cells (CTCs) capturing efficiency and lack of regulation capability on CTC-supportive metastatic niches (MNs) are two main obstacles hampering the clinical translation of conventional liposomes for the treatment of metastatic ...
Jiaxuan Xia, S. Ma, Xi Zhu, Chen Chen, Ru Zhang, Zhonglian Cao, Xing Chen, Longlong Zhang, Ying Zhu, Shuya Zhang, Shiyi Li, Guolong Gu, Xunbin Wei, Kunqian Yu, Jianxin Wang   +14 more
semanticscholar   +1 more source

The Content and Principle of the Rare Ginsenosides Produced from Gynostemma pentaphyllum after Heat Treatment

Molecules, 2023
Ginsenoside Rg3, Rk1, and Rg5, rare ginsenosides from Panax ginseng, have many pharmacological effects, which have attracted extensive attention. They can be obtained through the heat treatment of Gynostemma pentaphyllum. In this study, scanning electron
Xin-Can Li, Fang-Fang Li, Wen-Jing Pei, Jing Yang, Yu-Long Gu, Xiang-Lan Piao   +5 more
doaj   +1 more source

Acute and repeated dose 26-week oral toxicity study of 20(S)-ginsenoside Rg3 in Kunming mice and Sprague–Dawley rats

Journal of Ginseng Research, 2020
Background: 20(S)-ginsenoside-Rg3 (C42H72O13), a natural triterpenoid saponin, is extracted from red ginseng. The increasing use of 20(S)-ginsenoside Rg3 has raised product safety concerns. Methods: In acute toxicity, 20(S)-ginsenoside Rg3 was singly and
Chunmei Li, Zhezhe Wang, Guisheng Li, Zhenhua Wang, Jianrong Yang, Yanshen Li, Hongtao Wang, Haizhu Jin, Junhua Qiao, Hongbo Wang, Jingwei Tian, Albert W. Lee, Yonglin Gao   +12 more
doaj   +1 more source