Results 41 to 50 of about 20,751 (192)

Two Ginseng UDP-Glycosyltransferases Synthesize Ginsenoside Rg3 and Rd [PDF]

Plant and Cell Physiology, 2014
Ginseng is a medicinal herb that requires cultivation under shade conditions, typically for 4-6 years, before harvesting. The principal components of ginseng are ginsenosides, glycosylated tetracyclic terpenes. Dammarene-type ginsenosides are classified into two groups, protopanaxadiol (PPD) and protopanaxatriol (PPT), based on their hydroxylation ...
Jung, SC Jung, Suk-Chae, Kim, W Kim, Woohyun, Park, SC Park, Sung Chul, Jeong, J Jeong, Jinkil, Park, MK Park, Myung Keun, Lim, S Lim, Soohwan, Lee, Y Lee, Yeon, Im, WT Im, Wan-Taek, Lee, JH Lee, Jun Hyoung, Choi, GT Choi, Gil-Tsu, Kim, SC Kim, Sun Chang   +10 more
openaire   +3 more sources

Anticancer effects of ginsenoside Rg3 (Review)

International Journal of Molecular Medicine, 2017
Cancer is a life-threatening disease with an alarmingly increased annual mortality rate globally. Although various therapies are employed for cancer, the final effect is not satisfactory. Chemotherapy is currently the most commonly used treatment option.
Mengyao, Sun, Ying, Ye, Ling, Xiao, Xinya, Duan, Yongming, Zhang, Hong, Zhang   +5 more
openaire   +3 more sources

Targeting therapy and tumor microenvironment remodeling of triple-negative breast cancer by ginsenoside Rg3 based liposomes

Journal of Nanobiotechnology, 2022
The chemotherapy effect of docetaxel (DTX) against triple-negative breast cancer (TNBC) remains mediocre and limited when encapsulated in conventional cholesterol liposomes, mainly ascribed to poor penetration and immunosuppressive tumor microenvironment
Jiaxuan Xia, Shuya Zhang, Ru Zhang, Anni Wang, Ying Zhu, Mei Dong, S. Ma, Chao Hong, Sheng Liu, Dan Wang, Jianxin Wang   +10 more
semanticscholar   +1 more source

Targeting Ferroptosis With Ginsenoside Rg3 Alleviates Intervertebral Disc Degeneration. [PDF]

Orthop Surg
ABSTRACTObjectiveIntervertebral disc degeneration (IVDD) has been closely associated with ferroptosis in nucleus pulposus cells (NPCs), the underlying regulatory mechanisms and therapeutic strategies remain poorly defined. This study aims to delineate how ginsenoside Rg3 mitigates IVDD progression through ferroptosis suppression, providing a basis for ...
Xu W, Geng F, Zhang K, Wang Y.
europepmc   +3 more sources

Ginsenoside rg3 reduces body weight by regulating fat content and browning in obese mice

Journal of Traditional Chinese Medical Sciences, 2021
Objective: To determine the effects of ginsenoside rg3 on the body weight of C57BL/6J obese mice and to investigate its underlying weight loss mechanisms with a focus on white fat browning-related factors.
Qianqian Mu, Jiacheng Zuo, Dandan Zhao, Xiaoshan Zhou, Jing Hua, Ying Bai, Fangfang Mo, Xin Fang, Min Fu, Sihua Gao   +9 more
doaj   +1 more source

Ginsenoside Rg3 nanoparticles with permeation enhancing based chitosan derivatives were encapsulated with doxorubicin by thermosensitive hydrogel and anti-cancer evaluation of peritumoral hydrogel injection combined with PD-L1 antibody

Biomaterials Research, 2022
Background Combination of chemotherapy and immune checkpoint inhibitor therapy has greatly improved the anticancer effect on multiple malignancies. However, the efficiency on triple-negative breast cancer (TNBC) is limited, since most patients bear “cold”
Hao Wu, Guoli Wei, Lixia Luo, Lingchang Li, Yibo Gao, Xiaobin Tan, Sen Wang, Haoxiao Chang, Yuxi Liu, Ying-jie Wei, Jie Song, Zhenhai Zhang, Jiege Huo   +12 more
semanticscholar   +1 more source

Conjugation of Ginsenoside Rg3 with Gold Nanoparticles [PDF]

Bulletin of the Korean Chemical Society, 2011
Ginsenoside Rg3 was reported to have important biological activities. We demonstrate conjugation and quantification procedures of ginsenoside Rg3 to gold nanoparticles for future biological and medical applications. Ginsenoside Rg3 was conjugated to spherical gold nanoparticles using a bifunctional heptaethylene glycol linker.
You-Mie Park, A-Rang Im, Eun-Ji Joo, Ji-Hye Lee, Hyeung-Geun Park, Young-Hwa Kang, Robert J. Linhardt, Yeong-Shik Kim   +7 more
openaire   +1 more source

Ginsenoside Rg3, a promising agent for NSCLC patients in the pandemic: a large-scale data mining and systemic biological analysis

Journal of Ginseng Research, 2023
Introduction: Non-small cell lung cancer (NSCLC) patients are particularly vulnerable to the Coronavirus Disease-2019 (COVID-19). Currently, no anti-NSCLC/COVID-19 treatment options are available.
Zhenjie Zhuang, Qianying Chen, Xiaoying Zhong, Huiqi Chen, Runjia Yu, Ying Tang   +5 more
doaj   +1 more source

Preparation of Ginsenoside Rg3 and Protection against H2O2-Induced Oxidative Stress in Human Neuroblastoma SK-N-SH Cells

Journal of Chemistry, 2014
The aim of this study is to evaluate the protection of ginsenoside Rg3 against oxidative stress in human neuroblastoma SK-N-SH cells. 20(R)-ginsenoside Rg3 (20(R)-Rg3) and 20(S)-ginsenoside Rg3 (20(S)-Rg3) were prepared by the method of chemical ...
Gang Li, Xiao-xiao Zhang, Lin Lin, Xiao-ning Liu, Cheng-jun Ma, Ji Li, Chi-bo Wang   +6 more
doaj   +1 more source

Stereospecificity of Ginsenoside Rg3 Action on Ion Channels

Molecules and Cells, 2004
Ginsenosides, active ingredients of Panax ginseng, exist as stereoisomers depending on the position of the hydroxyl group on carbon-20; i.e. 20(R)-ginsenoside and 20(S)-ginsenoside are epimers. We have shown previously that the mixture of 20(R)- and 20(S)-ginsenosides regulates ion channel activity.
Sang Min, Jeong, Jun-Ho, Lee, Jong-Hoon, Kim, Byung-Hwan, Lee, In-Soo, Yoon, Joon-Hee, Lee, Dong-Hyun, Kim, Hyewhon, Rhim, Yangmee, Kim, Seung-Yeol, Nah   +9 more
openaire   +2 more sources