Results 61 to 70 of about 20,751 (192)

Ginsenoside Rk1 is a novel inhibitor of NMDA receptors in cultured rat hippocampal neurons

Journal of Ginseng Research, 2020
Background: Ginsenoside Rk1, a saponin component isolated from heat-processed Panax ginseng Meyer, has been implicated in the regulation of antitumor and anti-inflammatory activities.
Nayeon Ryoo, Md. Ataur Rahman, Hongik Hwang, Sung Kwon Ko, Seung-Yeol Nah, Hyoung-Chun Kim, Hyewhon Rhim   +6 more
doaj   +1 more source

Integration of transcriptomics and metabolomics to reveal the effect of ginsenoside Rg3 on allergic rhinitis in mice.

Food & Function, 2023
Increasing studies have demonstrated that ginsenoside Rg3 (Rg3) plays an important role in the prevention and treatment of various diseases, including allergic lower airway inflammation such as asthma.
Jianming Liu, Na Yang, Xingcheng Yi, Guoqiang Wang, Cuizhu Wang, Hongqiang Lin, Liwei Sun, Fang Wang, Dongdong Zhu   +8 more
semanticscholar   +1 more source

Conversion of Protopanaxadiol Type Saponins to Ginsenoside Rg3 by Lemon [PDF]

Natural Product Communications, 2012
The ability of fresh lemon ( Citrus limon) to convert protopanaxadiol-type saponins into ginsenoside Rg3 was investigated, and the structures of 20( S)-ginsenoside Rg3 (1) and 20( R)-ginsenoside Rg3 (2) were identified by 1H NMR and 13C NMR spectroscopy. The experiment showed that lemon possesses the strong ability to hydrolyze ginsenosides.
Cheng-Peng, Sun, Wei-Ping, Gao, Bao-Zhong, Zhao, Le-Qin, Cheng   +3 more
openaire   +2 more sources

Ginsenoside Rg3 Attenuates Lipopolysaccharide-Induced Acute Lung Injury via MerTK-Dependent Activation of the PI3K/AKT/mTOR Pathway

Frontiers in Pharmacology, 2018
Acute lung injury (ALI) is a common clinical disease with high morbidity in both humans and animals. Ginsenoside Rg3, a type of traditional Chinese medicine extracted from ginseng, is widely used to cure many inflammation-related diseases.
Jing Yang, Senyang Li, Luyao Wang, Fen Du, Xiaoliu Zhou, Qiqi Song, Junlong Zhao, Rui Fang   +7 more
doaj   +1 more source

Ginsenoside Rg3 Reduces the Toxicity of Graphene Oxide Used for pH-Responsive Delivery of Doxorubicin to Liver and Breast Cancer Cells

Pharmaceutics, 2023
Doxorubicin (DOX) is extensively used in chemotherapy, but it has serious side effects and is inefficient against some cancers, e.g., hepatocarcinoma.
S. Rahimi, Daniel van Leeuwen, F. Roshanzamir, S. Pandit, Lei Shi, Nima Sasanian, Jens Nielsen, E. K. Esbjörner, I. Mijakovic   +8 more
semanticscholar   +1 more source

Generation and Characterization of Monoclonal Antibody to Ginsenoside Rg3

Biological and Pharmaceutical Bulletin, 2009
While studying the mechanism of ginsenoside Rg3 (G-Rg3) on tumor inhibition, we produced monoclonal antibody to G-Rg3 for more specific investigation. We immunized Balb/c mice to G-Rg3 conjugated bovine serum albumin (BSA) by intraperitoneal injection and hybridized splenocytes from those immunized mice and myeloma cells.
Eun Ji, Joo, Young Wan, Ha, Heungsop, Shin, Sung Ho, Son, Yeong Shik, Kim   +4 more
openaire   +3 more sources

A bioactive ginsenoside alleviates hepatocellular ferroptosis induced by oxidized phospholipid accumulation in nonalcoholic steatohepatitis

iMeta, EarlyView.
Schematic representation showing that 20 (S)‐Rg3 improves mouse NASH. 20(S)‐Rg3 reduces OxPLs levels and ameliorates ferroptosis in the liver of NASH mice. Mechanistically, 20(S)‐Rg3 activates SPOP. Meanwhile, SPOP attenuates the ATF3‐mediated transcriptional repression of NUPR1 by enhancing the K48‐linked ubiquitination of ATF3.
Yibo Zong, Guo Long, Tiantian Gu, Pan Huang, Yong Tian, Wenwu Xu, Xiheng Hu, Dazun Shi, Lizhi Lu, Tao Zeng   +9 more
wiley   +1 more source

Component Analysis of Cultivated Ginseng, Red Ginseng, Cultivated Wild Ginseng, and Red Wild Ginseng Using HPLC Method

Journal of Pharmacopuncture, 2008
Objectives : The aim of this experiment is to provide an differentiation of ginseng, red ginseng, cultivated wild ginseng(CWG), and red wild ginseng(RWG) through component analysis using HPLC(High Performance Liquid Chromatography, hereafter HPLC ...
Jang Ho, Lee, Ki Rok, Kwon, Bae Chun, Cha   +2 more
doaj   +1 more source

Exploration and Characterization of Novel Glycoside Hydrolases from the Whole Genome of Lactobacillus ginsenosidimutans and Enriched Production of Minor Ginsenoside Rg3(S) by a Recombinant Enzymatic Process

Biomolecules, 2020
Background: Several studies have reported that ginsenoside Rg3(S) is effective in treating metastatic diseases, obesity, and various cancers, however, its presence in white ginseng cannot be estimated, and only a limited amount is present in red ginseng.
Muhammad Zubair Siddiqi, Sathiyaraj Srinivasan, Hye Yoon Park, Wan-Taek Im   +3 more
doaj   +1 more source

Comparative analysis of the expression level of recombinant ginsenoside-transforming β-glucosidase in GRAS hosts and mass production of the ginsenoside Rh2-Mix. [PDF]

PLoS ONE, 2017
The ginsenoside Rh2, a pharmaceutically active component of ginseng, is known to have anticancer and antitumor effects. However, white ginseng and red ginseng have extremely low concentrations of Rh2 or Rh2-Mix [20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3].
Muhammad Zubair Siddiqi, Chang-Hao Cui, Seul-Ki Park, Nam Soo Han, Sun-Chang Kim, Wan-Taek Im   +5 more
doaj   +1 more source