Results 181 to 190 of about 3,775 (207)
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Ginsenoside Rh2 Inhibits Angiogenesis in Prostate Cancer by Targeting CNNM1
Journal of Nanoscience and Nanotechnology, 2019To explore the molecular mechanism by which ginsenoside Rh2 (G-Rh2) inhibits prostate cancer by regulating vascular growth. Different concentrations of G-Rh2 with three prostate cancer cell lines (LNCaP, PC3 and DU145) were transplanted in nude mice, and tumor mass volume was measured over time.
Yaqiang, Huang +5 more
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Generation of ginsenosides Rg3 and Rh2 from North American ginseng
Phytochemistry, 2004Rg3 and Rh2 ginsenosides are primarily found in Korean red ginseng root (Panax ginseng C.A. Meyer) and valued for their bioactive properties. We quantified both Rh2 and Rg3 ginseng leaf and Rg3 from root extracts derived from North American ginseng (Panax quinquefolius).
David G, Popovich, David D, Kitts
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Clinical Pharmacology in Drug Development, 2020
AbstractGinsenoside H dripping pill (GH) is a novel clinical‐stage adjuvant for the treatment of non‐small cell lung cancer. In this study, the pharmacokinetics of ginsenoside Rh2, the major anticancer ingredient of GH, was investigated in healthy volunteers.
Zhenlei, Wang +6 more
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AbstractGinsenoside H dripping pill (GH) is a novel clinical‐stage adjuvant for the treatment of non‐small cell lung cancer. In this study, the pharmacokinetics of ginsenoside Rh2, the major anticancer ingredient of GH, was investigated in healthy volunteers.
Zhenlei, Wang +6 more
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Research Progress on the Antitumor Molecular Mechanism of Ginsenoside Rh2
The American Journal of Chinese MedicineCancer has evolved into a substantial public health concern as the second-leading cause of mortality globally. Radiotherapy and chemotherapy have been the two most widely used cancer therapies in recent years; however, both have drawbacks. Therefore, the focus has shifted to the creation of herbal medicines, the extraction of active ingredients ...
Lan Yang +4 more
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Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells
Archives of Pharmacal Research, 2004Ginseng has an anti-cancer effect in several cancer models. This study was to characterize active constituents of ginseng and their effects on proliferation of prostate cancer cell lines, LNCaP and PC3. Cell proliferation was measured by [3H]thymidine incorporation, the intracellular calcium concentration by a dual-wavelength spectrophotometer system ...
Hyun-Sook, Kim +5 more
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Antimicrobial effects of the ginsenoside Rh2 on monospecies and multispecies cariogenic biofilms
Journal of Applied Microbiology, 2019To investigate the effects of the ginsenoside Rh2 on monospecies and multispecies cariogenic biofilms and explore the mechanism of the antibiofilm effect of Rh2 in vitro.Streptococcus mutans, Streptococcus sobrinus and Streptococcus sanguinis were chosen to form the monospecies or multispecies biofilms.
X. Cao, Q. Ye, M. Fan, C. Liu
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Therapeutic Effects of Ginsenoside Rh2 in the Treatment of Sepsis
Journal of Biobased Materials and BioenergyPanax ginseng, a well-known traditional Chinese medicine (TCM) with a wide range of pharmacological activities, has been extensively investigated. However, its specific pharmacological mechanism in preventing and treating sepsis remains elusive.
Fang Xiao +4 more
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The International Journal of Biochemistry & Cell Biology, 1998
Ginsenoside Rh1 or Rh2 differentiated B16 melanoma or F9 teratocarnoma to phenotypic normal melanocyte-like cells or parietal endoderm-like cells. Ginsenoside Rh3 and Rh4 were recently isolated from Panax ginseng, but their biochemical and pharmacological effects remain unidentified.
Y S, Kim, D S, Kim, S I, Kim
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Ginsenoside Rh1 or Rh2 differentiated B16 melanoma or F9 teratocarnoma to phenotypic normal melanocyte-like cells or parietal endoderm-like cells. Ginsenoside Rh3 and Rh4 were recently isolated from Panax ginseng, but their biochemical and pharmacological effects remain unidentified.
Y S, Kim, D S, Kim, S I, Kim
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[Differentiation of B16 melanoma cells induced by ginsenoside RH2].
Yao xue xue bao = Acta pharmaceutica Sinica, 1999The effect of ginsenoside Rh2, a constituent isolated from Panax ginseng C. A. Meyer, on the growth of tumor cells in vitro was investigated. The results showed that Rh2 inhibited the growth of B16 cells at the concentration of 10 micrograms.ml-1 (IC50: 4.1 micrograms.ml-1).
L J, Xia, R, Han
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Computer-driven formulation development of Ginsenoside Rh2 ternary solid dispersion
Drug Delivery and Translational Research(20 S)-Ginsenoside Rh2 is a natural saponin derived from Panax ginseng Meyer (P. ginseng), which showed significantly potent anticancer properties. However, its low water solubility and bioavailability strongly restrict its pharmaceutical applications.
Tianshu Lu +8 more
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