Journal of Ginseng Research, 2017 Background: Ginsenoside Rh2 (G-Rh2) is a ginseng saponin that is widely investigated because of its remarkable antitumor activity. However, the molecular mechanism by which (20S) G-Rh2 triggers its functions and how target animals avoid its cytotoxic ...
Yingjia Lin, Ying-Hua Jin
exaly +5 more sources
Ginsenoside-Rh2 inhibits U251 glioma cell migration and invasion via the Gab2/Akt2 pathway [PDF]
Frontiers in OncologyBackgroundGlioma, the most common primary intracranial tumor, exhibits high recurrence and mortality rates. Ginsenoside-Rh2 (GS-Rh2), an active compound from Panax ginseng, has shown anti-tumor potential.
Wei Sun +6 more
doaj +2 more sources
Nanoparticle conjugation of ginsenoside Rh2 enhanced antitumor efficacy on hepatocellular carcinoma [PDF]
Scientific ReportsGinsenoside Rh2 (Rh2) is one of the main bioactive ginsenosides that act as a natural antitumor drug. However, the clinical application of Rh2 is limited by its low solubility in water.
Fengkai Sun +6 more
doaj +2 more sources
Nano-Micro Letters, 2020 Liposomes hold great potential in anti-cancer drug delivery and the targeting treatment of tumors. However, the clinical therapeutic efficacy of liposomes is still limited by the complexity of tumor microenvironment (TME) and the insufficient ...
jiaxuan Xia, Dan Wang, Jing Qin
exaly +3 more sources
Origin and adaptation of green‐sensitive (RH2) pigments in vertebrates [PDF]
FEBS Open Bio, 2020 One of the critical times for the survival of animals is twilight where the most abundant visible lights are between 400 and 550 nanometres (nm). Green‐sensitive RH2 pigments help nonmammalian vertebrate species to better discriminate wavelengths in this
Shozo Yokoyama, Huiyong Jia
doaj +3 more sources
Ginsenoside Rh2 as a novel PIN1 inhibitor disrupting the cancer stem cell-like phenotype in non-small cell lung cancer [PDF]
Journal of Translational MedicineBackground The widespread issue of drug resistance remains a major obstacle in the treatment of lung cancer, particularly non-small cell lung cancer (NSCLC), making the development of novel adjuvant therapeutic strategies an urgent priority.
Xiyu Liu +8 more
doaj +2 more sources
Ginsenoside Rh2 Suppresses the Fanconi Anemia Pathway by Inhibiting NF-κB-Mediated FANCL Transcription in Bladder Cancer [PDF]
Dose-ResponseObjectives Cisplatin, a frontline chemotherapeutic agent for bladder cancer (BC), induces DNA interstrand crosslinks that are primarily repaired through the Fanconi anemia (FA) pathway.
Chen Li +3 more
doaj +2 more sources
Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2
Frontiers in Pharmacology, 2022 Aim: The 20(S)-ginsenoside Rh2 (Rh2) is being developed as a new antitumor drug. However, to date, little is known about the kinetics of its deglycosylation metabolite (protopanoxadiol) (PPD) following Rh2 administration.
Hong-can Ren +20 more
doaj +1 more source
Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics. [PDF]
PLoS ONE, 2012 Chirality is an interesting topic and it is meaningful to explore the interactions between chiral small molecules and stereoselective biomacromolecules, with pre-clinical and clinical significances.
Jingwei Zhang +6 more
doaj +1 more source
Journal of Ginseng Research, 2022 Background: In addition to its use as a health food, ginseng is used in cosmetics and shampoo because of its extensive health benefits. The ginsenoside, Rh2, is a component of ginseng that inhibits tumor cell proliferation and differentiation, promotes ...
Hyunji Lee +3 more
doaj +1 more source