Ginsenoside Rh2 inhibits breast cancer cell growth viaERβ-TNFα pathway [PDF]
Acta Biochimica et Biophysica Sinica, 2022 Ginsenoside Rh2 is one of rare panaxidiols extracted from Panax ginseng and a potential estrogen receptor ligand that exhibits moderate estrogenic activity.
Peng Kunjian +11 more
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Influence of Auricularia cornea Polysaccharide Coating on the Stability and Antioxidant Activity of Liposomes Ginsenoside Rh2 [PDF]
Foods, 2023 Liposomes (Lip) are microstructures containing lipid and aqueous phases for encapsulation and delivery of bioactivators. In this study, Ginsenoside Rh2 liposomes (Rh2−Lip) were prepared by a thin-film hydrated ultrasonic binding method.
Minghui Wang +6 more
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Ginsenoside Rh2 regulates triple-negative breast cancer proliferation and apoptosis via the IL-6/JAK2/STAT3 pathway [PDF]
Frontiers in PharmacologyIntroductionTriple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer to treat. While previous studies have demonstrated that ginsenoside Rh2 induces apoptosis in TNBC cells, the specific molecular targets and underlying ...
Rumeng Ding +5 more
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Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2 [PDF]
Molecules, 2022 Ginsenoside Rh2 increases the efficacy of doxorubicin (DOX) treatment in murine models of solid and ascites Ehrlich’s adenocarcinoma. In a solid tumor model (treatment commencing 7 days after inoculation), DOX + Rh2 co-treatment was significantly more ...
Alexander Popov +14 more
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Nanoparticle conjugation of ginsenoside Rh2 enhanced antitumor efficacy on hepatocellular carcinoma [PDF]
Scientific ReportsGinsenoside Rh2 (Rh2) is one of the main bioactive ginsenosides that act as a natural antitumor drug. However, the clinical application of Rh2 is limited by its low solubility in water.
Fengkai Sun +6 more
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(20S) Ginsenoside Rh2-Activated, Distinct Apoptosis Pathways in Highly and Poorly Differentiated Human Esophageal Cancer Cells [PDF]
Molecules, 2022 Ginsenoside Rh2 (G-Rh2), a rare ginsenoside isolated from red ginseng, has considerable anti-cancer activity and induces apoptosis in a variety of cancer cells, but its activity in esophageal cancer cells is unclear.
He Li +4 more
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Synergistic Effect of Ginsenoside Rh2 Combines with Ionizing Radiation on CT26/luc Colon Carcinoma Cells and Tumor-Bearing Animal Model [PDF]
Pharmaceuticals, 2023 Background: The local tumor control rate of colon cancer by radiotherapy is unsatisfactory due to recurrence and radioresistance. Ginsenoside Rh2 (Rh2), a panoxadiol saponin, possesses various antitumor effects.
Shan-Chih Lee +7 more
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Veterinary Medicine and ScienceObjective To evaluate the therapeutic potential of Ginsenoside Rh2 in mice experimentally infected with Cryptosporidium parvum and to compare the efficacy of two Ginsenoside Rh2 dosing regimens. Animals Fifty male BALB/c mice, aged four weeks, were used.
Esengul Yildirim, Engin Balikci
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Ginsenoside Rh2 Suppresses the Fanconi Anemia Pathway by Inhibiting NF-κB-Mediated FANCL Transcription in Bladder Cancer [PDF]
Dose-ResponseObjectives Cisplatin, a frontline chemotherapeutic agent for bladder cancer (BC), induces DNA interstrand crosslinks that are primarily repaired through the Fanconi anemia (FA) pathway.
Chen Li +3 more
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Ginsenoside-Rh2 inhibits U251 glioma cell migration and invasion via the Gab2/Akt2 pathway [PDF]
Frontiers in OncologyBackgroundGlioma, the most common primary intracranial tumor, exhibits high recurrence and mortality rates. Ginsenoside-Rh2 (GS-Rh2), an active compound from Panax ginseng, has shown anti-tumor potential.
Wei Sun +6 more
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