Results 1 to 10 of about 3,771 (207)

Ginsenoside Rh2 inhibits breast cancer cell growth via ERβ-TNFα pathway. [PDF]

Acta Biochim Biophys Sin (Shanghai), 2022
Ginsenoside Rh2 is one of rare panaxidiols extracted from Panax ginseng and a potential estrogen receptor ligand that exhibits moderate estrogenic activity.
Peng K, Luo T, Li J, Huang J, Dong Z, Liu J, Pi C, Zou Z, Gu Q, Liu O, Zhang JT, Luo ZY.   +11 more
europepmc   +3 more sources

Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2. [PDF]

Molecules, 2022
Ginsenoside Rh2 increases the efficacy of doxorubicin (DOX) treatment in murine models of solid and ascites Ehrlich’s adenocarcinoma. In a solid tumor model (treatment commencing 7 days after inoculation), DOX + Rh2 co-treatment was significantly more ...
Popov A, Klimovich A, Styshova O, Tsybulsky A, Hushpulian D, Osipyants A, Khristichenko A, Kazakov S, Ahuja M, Kaidery N, Thomas B, Tishkov V, Brown A, Gazaryan I, Poloznikov A.   +14 more
europepmc   +5 more sources

Ginsenoside Rh2 regulates triple-negative breast cancer proliferation and apoptosis via the IL-6/JAK2/STAT3 pathway. [PDF]

Front Pharmacol
IntroductionTriple-negative breast cancer (TNBC) is the most challenging subtype of breast cancer to treat. While previous studies have demonstrated that ginsenoside Rh2 induces apoptosis in TNBC cells, the specific molecular targets and underlying ...
Ding R, Kan Q, Wang T, Xiao R, Song Y, Li D.   +5 more
europepmc   +5 more sources

Influence of Auricularia cornea Polysaccharide Coating on the Stability and Antioxidant Activity of Liposomes Ginsenoside Rh2. [PDF]

Foods, 2023
Liposomes (Lip) are microstructures containing lipid and aqueous phases for encapsulation and delivery of bioactivators. In this study, Ginsenoside Rh2 liposomes (Rh2−Lip) were prepared by a thin-film hydrated ultrasonic binding method.
Wang M, Li Q, Li S, Zhao Y, Jiang X, He S, Liu J.   +6 more
europepmc   +2 more sources

c-MYC-mediated TRIB3/P62⁺ aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2. [PDF]

Acta Pharm Sin B, 2022
The mammalian target of rapamycin (mTOR) pathway is abnormally activated in lung cancer. However, the anti-lung cancer effect of mTOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an active component of Panax ginseng C. A.
Su MX, Xu YL, Jiang XM, Huang MY, Zhang LL, Yuan LW, Xu XH, Zhu Q, Gao JL, Lu JH, Chen X, Huang MQ, Wang Y, Lu JJ.   +13 more
europepmc   +2 more sources

Nanoparticle conjugation of ginsenoside Rh2 enhanced antitumor efficacy on hepatocellular carcinoma. [PDF]

Sci Rep
Ginsenoside Rh2 (Rh2) is one of the main bioactive ginsenosides that act as a natural antitumor drug. However, the clinical application of Rh2 is limited by its low solubility in water.
Sun F, Liu J, Gao S, Zhang M, Sun X, Tian Y, Wang S.   +6 more
europepmc   +2 more sources

Synergistic Effect of Ginsenoside Rh2 Combines with Ionizing Radiation on CT26/luc Colon Carcinoma Cells and Tumor-Bearing Animal Model. [PDF]

Pharmaceuticals (Basel), 2023
Background: The local tumor control rate of colon cancer by radiotherapy is unsatisfactory due to recurrence and radioresistance. Ginsenoside Rh2 (Rh2), a panoxadiol saponin, possesses various antitumor effects.
Lee SC, Shen CY, Wang WH, Lee YP, Liang KW, Chou YH, Tyan YS, Hwang JJ.   +7 more
europepmc   +2 more sources

(20S) Ginsenoside Rh2-Activated, Distinct Apoptosis Pathways in Highly and Poorly Differentiated Human Esophageal Cancer Cells. [PDF]

Molecules, 2022
Ginsenoside Rh2 (G-Rh2), a rare ginsenoside isolated from red ginseng, has considerable anti-cancer activity and induces apoptosis in a variety of cancer cells, but its activity in esophageal cancer cells is unclear.
Li H, Han C, Chen C, Han G, Li Y.
europepmc   +2 more sources

Ginsenoside Rh2-Liposome Potentiate Vaccine Immunity through Enhanced MHC‑I Presentation. [PDF]

ACS Omega
This study aimed to evaluate the immune-enhancing efficacy and mechanism of liposome-Rh2 as a novel vaccine adjuvant. By using an integrated preparation strategy that combined ethanol injection with high-pressure homogenization, we successfully fabricated a stable liposome-Rh2 adjuvant.
Nie Q, Chen Z, Gong W, Cao W, Wang X, Liu Y, Zhang S, Yang Y, Meng Z.   +8 more
europepmc   +3 more sources

Ginsenoside-Rh2 inhibits U251 glioma cell migration and invasion via the Gab2/Akt2 pathway. [PDF]

Front Oncol
BackgroundGlioma, the most common primary intracranial tumor, exhibits high recurrence and mortality rates. Ginsenoside-Rh2 (GS-Rh2), an active compound from Panax ginseng, has shown anti-tumor potential.
Sun W, Li R, Wang L, Han W, Li J, Xu S, Sun X.   +6 more
europepmc   +2 more sources