Cancer Nanotechnology, 2022 Background Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and ...
Hua Yao +8 more
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Co-loaded simvastatin-ginsenoside Rh2 liposomes enhance cellular immune responses as vaccine adjuvants. [PDF]
Biochem Biophys RepVaccine adjuvants are pivotal in novel vaccine development, enhancing immunization and modulating immune responses. This study prepared liposomes loaded with simvastatin and ginsenoside Rh2 (LIPO-SIM-Rh2) via high-speed shearing, rotary evaporation, and ...
Huang Y +7 more
europepmc +2 more sources
Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop
Journal of Ginseng Research, 2021 Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer.
Chunmei Hu +5 more
doaj +1 more source
(20S) Ginsenoside Rh2 Inhibits STAT3/VEGF Signaling by Targeting Annexin A2. [PDF]
Int J Mol Sci, 2021 Signal transducers and activators of transcription 3 (STAT3) acts as a transcriptional signal transducer, converting cytokine stimulation into specific gene expression. In tumor cells, aberrant activation of the tyrosine kinase pathway leads to excessive
Wang YS, Chen C, Zhang SY, Li Y, Jin YH.
europepmc +2 more sources
Ginsenoside Rh2 Mitigates Endoplasmic Reticulum Stress-Induced Apoptosis and Inflammation and Through Inhibition of Hepatocyte-Macrophage Inflammatory Crosstalk. [PDF]
NutrientsBackground/Objectives: Endoplasmic reticulum stress (ERS) contributes to hepatocyte inflammation, triggered by prolonged exposure to lipotoxicity, and promotes non-alcoholic fatty liver disease (NAFLD) progression by recruiting and activating hepatic ...
Park S, Jeong I, Kim OK.
europepmc +2 more sources
Inhibition of macrophage polarization and pyroptosis in collagen-induced arthritis through MSC-exo and ginsenoside Rh2. [PDF]
Arthritis Res TherBackground Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, tissue damage, and fibrosis, significantly affecting the quality of life.
Zhou Z, Wu S, Li Y, Shao P, Jiang J.
europepmc +2 more sources
Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types
, 2021 Ginsenoside Rh2 (G-Rh2) is a natural bioactive product derived from Panax ginseng Meyer (P. ginseng). G-Rh2 exhibits anticancer activity in various human cancer cell lines both in vitro and in vivo by modulating several signaling pathways, such as those ...
Kim, Eungyung +7 more
core +1 more source
, 2023 Triple-negative breast cancer (TNBC) remains the most challenging breast cancer subtype due to its lack of targeted therapies and poor prognosis. In order to treat patients with these tumors, efforts have been made to explore feasible targets.
Aiguo Wu (315321) +19 more
core +1 more source
Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2. [PDF]
Drug DelivAnnonaceous acetogenins (ACGs) have potent anti-tumor activity, and the problems of their low solubility, hemolysis, and in vivo delivery have been solved by encapsulation into nanoparticles.
Ao H, Song H, Li J, Wang X.
europepmc +3 more sources
Transcriptome Analyses of the Anti-Proliferative Effects of 20(S)-Ginsenoside Rh2 on HepG2 Cells
Frontiers in Pharmacology, 2019 20(S)-ginsenoside Rh2 (Rh2), a well-known protopanaxadiol-type ginsenoside from Panax ginseng has especially gained attention for its anticancer activities on various types of human cancer cells.
Ji Zhang +7 more
doaj +1 more source