Network Pharmacology-Based Study on the Mechanism of Ginsenoside Rh2 in Glioma Treatment
Natural Product Communications, 2022 Glioma, originated from the neuroectoderm, is one of the prevalent tumors. It is reported that ginsenoside Rh2, a compound extracted from Panax ginseng, shows pharmacological activity in inhibiting the proliferation and metastasis of glioma cells ...
Xue Wu, Xiujiao Qin, Han Dong
doaj +1 more source
A novel autophagy activator ginsenoside Rh2 enhances the efficacy of immunogenic chemotherapy. [PDF]
Clin Transl Med, 2023 Yang J +11 more
europepmc +4 more sources
Influence of Ginsenoside Rh2 on Cardiomyocyte Pyroptosis in Rats with Acute Myocardial Infarction. [PDF]
Evid Based Complement Alternat Med, 2022 Objective. This paper intends to verify through in vivo experiments whether ginsenoside Rh2 (G-Rh2) can play an anti-inflammatory role by modulating cardiomyocyte (CM) pyroptosis in rats with acute myocardial infarction (AMI), thereby alleviating myocardial injury. Methods.
Song W, Dai B, Dai Y.
europepmc +3 more sources
Ginsenoside Rh2 suppresses colon cancer growth by targeting the miR-150-3p/SRCIN1/Wnt axis. [PDF]
Acta Biochim Biophys Sin (Shanghai), 2023 Ginsenoside Rh2, which is extracted from ginseng, exerts antitumor activity. Recent studies suggest that Rh2 may suppress the growth of colon cancer (CC) in vitro. However, the underlying mechanism remains unclear.
Li S +5 more
europepmc +2 more sources
Acta Pharmaceutica Sinica B, 2022 The mammalian target of rapamycin (mTOR) pathway is abnormally activated in lung cancer. However, the anti-lung cancer effect of mTOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an active component of Panax ginseng C. A.
Min-Xia Su +13 more
doaj +1 more source
Cancer Nanotechnology, 2022 Background Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and ...
Hua Yao +8 more
doaj +1 more source
Co-loaded simvastatin-ginsenoside Rh2 liposomes enhance cellular immune responses as vaccine adjuvants. [PDF]
Biochem Biophys RepVaccine adjuvants are pivotal in novel vaccine development, enhancing immunization and modulating immune responses. This study prepared liposomes loaded with simvastatin and ginsenoside Rh2 (LIPO-SIM-Rh2) via high-speed shearing, rotary evaporation, and ...
Huang Y +7 more
europepmc +2 more sources
Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop
Journal of Ginseng Research, 2021 Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer.
Chunmei Hu +5 more
doaj +1 more source
Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types [PDF]
, 2021 Ginsenoside Rh2 (G-Rh2) is a natural bioactive product derived from Panax ginseng Meyer (P. ginseng). G-Rh2 exhibits anticancer activity in various human cancer cell lines both in vitro and in vivo by modulating several signaling pathways, such as those ...
Kim, Eungyung +7 more
core +1 more source
Ginsenoside Rh2 Suppresses Neovascularization in Xenograft Psoriasis Model [PDF]
Cellular Physiology and Biochemistry, 2015 Background/Aims: Psoriasis is a common inflammatory skin disease of undetermined etiology and poor prognosis. The current therapies have focused on direct inhibition of local inflammation, e.g. through hormone treatments. However, neovascularization plays a critical role in the development of psoriasis but so far no therapies have been developed to ...
Jing Zhou +3 more
openaire +3 more sources