Ginsenoside Rh2 inhibits mesenchymal stem cell senescence by regulating mitochondrial and lysosomal function. [PDF]
Stem Cell Res TherBackground Mesenchymal stem cells (MSCs) undergo senescence after expansion and in vitro culture under oxidative stress, which limits their clinical application.
Zhuang J +4 more
europepmc +2 more sources
Journal of Ginseng Research, 2021 Background: Ginsenoside Rh2 is well known for many pharmacological activities, such as anticancer, antidiabetes, antiinflammatory, and antiobesity properties. Glycosyltransferases (GTs) are ubiquitous enzymes present in nature and are widely used for the
Dan-Dan Wang +7 more
doaj +1 more source
Network Pharmacology-Based Study on the Mechanism of Ginsenoside Rh2 in Glioma Treatment
Natural Product Communications, 2022 Glioma, originated from the neuroectoderm, is one of the prevalent tumors. It is reported that ginsenoside Rh2, a compound extracted from Panax ginseng, shows pharmacological activity in inhibiting the proliferation and metastasis of glioma cells ...
Xue Wu, Xiujiao Qin, Han Dong
doaj +1 more source
Clinical and Experimental Hypertension, 2023 Background Acute myocardial infarction (AMI) is one of the most important causes of mortality among patients with cardiovascular disease. Ginsenoside Rh2 plays a protective role in cardiovascular diseases.
Hong Peng +4 more
doaj +1 more source
Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. [PDF]
, 2013 The aryl hydrocarbon receptor (AHR) is a ligand-dependent transcription factor that mediates many of the biological and toxicological actions of structurally diverse chemicals.
Bonati, Laura +10 more
core +6 more sources
Ginsenoside Rh2 Suppresses Neovascularization in Xenograft Psoriasis Model [PDF]
Cellular Physiology and Biochemistry, 2015 Background/Aims: Psoriasis is a common inflammatory skin disease of undetermined etiology and poor prognosis. The current therapies have focused on direct inhibition of local inflammation, e.g. through hormone treatments. However, neovascularization plays a critical role in the development of psoriasis but so far no therapies have been developed to ...
Jing Zhou +3 more
openaire +3 more sources
Comparative analysis of the expression level of recombinant ginsenoside-transforming β-glucosidase in GRAS hosts and mass production of the ginsenoside Rh2-Mix. [PDF]
PLoS ONE, 2017 The ginsenoside Rh2, a pharmaceutically active component of ginseng, is known to have anticancer and antitumor effects. However, white ginseng and red ginseng have extremely low concentrations of Rh2 or Rh2-Mix [20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3].
Muhammad Zubair Siddiqi +5 more
doaj +1 more source
Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics. [PDF]
PLoS ONE, 2012 Chirality is an interesting topic and it is meaningful to explore the interactions between chiral small molecules and stereoselective biomacromolecules, with pre-clinical and clinical significances.
Jingwei Zhang +6 more
doaj +1 more source
Cancer Nanotechnology, 2022 Background Inorganic nanocomposites especially Au nanostructures have exhibited outstanding physicochemical properties in biomedical fields. For further clinical applications on theranostics, especially drug delivery, numerous explorations of green and ...
Hua Yao +8 more
doaj +1 more source
Ginsenoside Rh2 reduces m6A RNA methylation in cancer via the KIF26B-SRF positive feedback loop
Journal of Ginseng Research, 2021 Background: The underlying mechanisms of the potential tumor-suppressive effects of ginsenoside Rh2 are complex. N6-methyladenosine (m6A) RNA methylation is usually dysregulated in cancer.
Chunmei Hu +5 more
doaj +1 more source