Results 21 to 30 of about 2,941 (150)

Ginsenoside Rh2 Inhibits NLRP3 Inflammasome Activation and Improves Exosomes to Alleviate Hypoxia-Induced Myocardial Injury [PDF]

Frontiers in Immunology, 2022
The inflammatory microenvironment after acute myocardial infarction (MI) is a key limiting factor in the clinical application of stem cell transplantation and paracrine exosome therapy.
Zhongwen Qi, Zhongwen Qi, Zhongwen Qi, Zhipeng Yan, Zhipeng Yan, Zhipeng Yan, Yueyao Wang, Yueyao Wang, Yueyao Wang, Nan Ji, Xiaoya Yang, Ao Zhang, Meng Li, Fengqin Xu, Junping Zhang, Junping Zhang   +15 more
doaj   +2 more sources

In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies

International Journal of Nanomedicine, 2017
Priyanka Singh,1,2 Yeon Ju Kim,1 Hina Singh,1 Sungeun Ahn,1 Verónica Castro-Aceituno,1 Deok Chun Yang1,2 1Department of Oriental Medicine Biotechnology, Ginseng Bank, 2Graduate School of Biotechnology, College of Life Sciences, Kyung Hee ...
Singh P, Kim YJ, Singh H, Ahn S, Castro-Aceituno V, Yang DC   +5 more
doaj   +1 more source

Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway [PDF]

Frontiers in Pharmacology, 2022
Ginsenoside Rh2 (G-Rh2), a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity.
Chao Song, Yue Yuan, Jing Zhou, Ziliang He, Yeye Hu, Yuan Xie, Nan Liu, Lei Wu, Ji Zhang   +8 more
doaj   +2 more sources

Ginsenoside Rh2 inhibits mesenchymal stem cell senescence by regulating mitochondrial and lysosomal function [PDF]

Stem Cell Research & Therapy
Background Mesenchymal stem cells (MSCs) undergo senescence after expansion and in vitro culture under oxidative stress, which limits their clinical application.
Jianjian Zhuang, Yue Li, Yi Ling Huang, Xiang Wang, Neng Ming Lin   +4 more
doaj   +2 more sources

Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells

Journal of Ginseng Research, 2018
Background: Ginsenoside Rh2 has been known to enhance the activity of immune cells, as well as to inhibit the growth of tumor cells. Although the repertoire of genes regulated by Rh2 is well-known in many cancer cells, the epigenetic regulation has yet ...
Hyunkyung Lee, Seungyeon Lee, Dawoon Jeong, Sun Jung Kim   +3 more
doaj   +2 more sources

Ginsenoside Rh2 regulates cardiomyocyte autophagy-dependent apoptosis through the PI3K-Akt-mTOR signaling pathway to attenuate doxorubicin-induced cardiotoxicity

Applied Biological Chemistry
Doxorubicin (DOX)-induced cardiotoxicity has become a major concern and is considered a limitation for the use of DOX in oncology treatment. Ginsenoside Rh2 (Rh2) is a ginseng extract with anti-inflammatory, antioxidant and cell cycle regulating ...
Youping Wu, Sheng Zhang, Liqiang Gu, Cong Xu, Xiaobo Lin, Hu Wang   +5 more
doaj   +2 more sources

Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications

Journal of Ginseng Research, 2021
Background: Ginsenoside Rh2 is well known for many pharmacological activities, such as anticancer, antidiabetes, antiinflammatory, and antiobesity properties. Glycosyltransferases (GTs) are ubiquitous enzymes present in nature and are widely used for the
Dan-Dan Wang, Yeon-Ju Kim, Nam In Baek, Ramya Mathiyalagan, Chao Wang, Yan Jin, Xing Yue Xu, Deok-Chun Yang   +7 more
doaj   +1 more source

Network Pharmacology-Based Study on the Mechanism of Ginsenoside Rh2 in Glioma Treatment

Natural Product Communications, 2022
Glioma, originated from the neuroectoderm, is one of the prevalent tumors. It is reported that ginsenoside Rh2, a compound extracted from Panax ginseng, shows pharmacological activity in inhibiting the proliferation and metastasis of glioma cells ...
Xue Wu, Xiujiao Qin, Han Dong
doaj   +1 more source

Ginsenoside Rh2 suppresses colon cancer growth by targeting the miR-150-3p/SRCIN1/Wnt axis. [PDF]

Acta Biochim Biophys Sin (Shanghai), 2023
Ginsenoside Rh2, which is extracted from ginseng, exerts antitumor activity. Recent studies suggest that Rh2 may suppress the growth of colon cancer (CC) in vitro. However, the underlying mechanism remains unclear.
Li S, Han W, He Q, Wang Y, Jin G, Zhang Y.   +5 more
europepmc   +2 more sources

c-MYC-mediated TRIB3/P62+ aggresomes accumulation triggers paraptosis upon the combination of everolimus and ginsenoside Rh2

Acta Pharmaceutica Sinica B, 2022
The mammalian target of rapamycin (mTOR) pathway is abnormally activated in lung cancer. However, the anti-lung cancer effect of mTOR inhibitors as monotherapy is modest. Here, we identified that ginsenoside Rh2, an active component of Panax ginseng C. A.
Min-Xia Su, Yu-Lian Xu, Xiao-Ming Jiang, Mu-Yang Huang, Le-Le Zhang, Luo-Wei Yuan, Xiao-Huang Xu, Qi Zhu, Jian-Li Gao, Jia-Hong Lu, Xiuping Chen, Ming-Qing Huang, Yitao Wang, Jin-Jian Lu   +13 more
doaj   +1 more source