Results 21 to 30 of about 3,001 (186)

Increased antitumor efficacy of ginsenoside Rh2 via mixed micelles: in vivo and in vitro evaluation [PDF]

Drug Delivery, 2020
The aim of this work is to apply Solutol® HS15 and TPGS to prepare self-assembled micelles loading with ginsenoside Rh2 to increase the solubility of ginsenoside Rh2, hence, improving the antitumor efficacy.
Xiaojing Xia, Jin Tao, Zhuwa Ji, Chencheng Long, Ying Hu, Zhiying Zhao   +5 more
doaj   +2 more sources

Ginsenoside Rb1 is transformed into Rd and Rh2 by Microbacterium trichothecenolyticum [PDF]

Journal of Microbiology and Biotechnology, 2013
Ginsenosides are the most important ingredient of ginseng and are known to possess many pharmacological and biological effects. Rb1, a major protopanaxadiol ginsenoside, is the most abundant ginsenoside in Panax ginseng C.A Meyer and can be hydrolyzed into more pharmaceutically potent minor ginsenosides.
Hansoo, Kim, Jeong-Hoon, Kim, Phil Young, Lee, Kwang-Hee, Bae, Sayeon, Cho, Byoung Chul, Park, Heungsop, Shin, Sung Goo, Park   +7 more
openaire   +3 more sources

Langerhans cell-like dendritic cells treated with ginsenoside Rh2 regulate the differentiation of Th1 and Th2 cells in vivo [PDF]

Open Chemistry, 2019
Ginsenoside Rh2 is one of the rare ginsenosides extracted from Panax ginseng C. A. Mey. The anti-allergic activity of ginsenoside Rh2 has been documented in some literature.
Liu Ying, Wu Qian, Li Peng, Liu Weijie, Jin Yongri, Li Xuwen, Shi Xiaolei   +6 more
doaj   +2 more sources

Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis [PDF]

Molecular Pain, 2022
Ginsenoside Rh2 is one of the major bioactive ginsenosides in Panax ginseng . Although Rh2 is known to enhance immune cells activity for treatment of cancer, its anti-inflammatory and neuroprotective effects have yet to be determined.
Yuan-Yuan Fu, Jian-Ke Cen, Hao-Lin Song, Si-Yuan Song, Zhi-Jun Zhang, Huan-Jun Lu   +5 more
doaj   +2 more sources

In situ preparation of water-soluble ginsenoside Rh2-entrapped bovine serum albumin nanoparticles: in vitro cytocompatibility studies [PDF]

International Journal of Nanomedicine, 2017
Priyanka Singh,1,2 Yeon Ju Kim,1 Hina Singh,1 Sungeun Ahn,1 Verónica Castro-Aceituno,1 Deok Chun Yang1,2 1Department of Oriental Medicine Biotechnology, Ginseng Bank, 2Graduate School of Biotechnology, College of Life Sciences, Kyung Hee ...
Singh P, Kim YJ, Singh H, Ahn S, Castro-Aceituno V, Yang DC   +5 more
doaj   +1 more source

Ginsenoside Rh2 Inhibits NLRP3 Inflammasome Activation and Improves Exosomes to Alleviate Hypoxia-Induced Myocardial Injury [PDF]

Frontiers in Immunology, 2022
The inflammatory microenvironment after acute myocardial infarction (MI) is a key limiting factor in the clinical application of stem cell transplantation and paracrine exosome therapy.
Zhongwen Qi, Zhongwen Qi, Zhongwen Qi, Zhipeng Yan, Zhipeng Yan, Zhipeng Yan, Yueyao Wang, Yueyao Wang, Yueyao Wang, Nan Ji, Xiaoya Yang, Ao Zhang, Meng Li, Fengqin Xu, Junping Zhang, Junping Zhang   +15 more
doaj   +2 more sources

Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway [PDF]

Frontiers in Pharmacology, 2022
Ginsenoside Rh2 (G-Rh2), a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity.
Chao Song, Yue Yuan, Jing Zhou, Ziliang He, Yeye Hu, Yuan Xie, Nan Liu, Lei Wu, Ji Zhang   +8 more
doaj   +2 more sources

Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells [PDF]

Journal of Ginseng Research, 2018
Background: Ginsenoside Rh2 has been known to enhance the activity of immune cells, as well as to inhibit the growth of tumor cells. Although the repertoire of genes regulated by Rh2 is well-known in many cancer cells, the epigenetic regulation has yet ...
Hyunkyung Lee, Seungyeon Lee, Dawoon Jeong, Sun Jung Kim   +3 more
doaj   +2 more sources

Ginsenoside Rh2 regulates cardiomyocyte autophagy-dependent apoptosis through the PI3K-Akt-mTOR signaling pathway to attenuate doxorubicin-induced cardiotoxicity [PDF]

Applied Biological Chemistry
Doxorubicin (DOX)-induced cardiotoxicity has become a major concern and is considered a limitation for the use of DOX in oncology treatment. Ginsenoside Rh2 (Rh2) is a ginseng extract with anti-inflammatory, antioxidant and cell cycle regulating ...
Youping Wu, Sheng Zhang, Liqiang Gu, Cong Xu, Xiaobo Lin, Hu Wang   +5 more
doaj   +2 more sources

Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applications

Journal of Ginseng Research, 2021
Background: Ginsenoside Rh2 is well known for many pharmacological activities, such as anticancer, antidiabetes, antiinflammatory, and antiobesity properties. Glycosyltransferases (GTs) are ubiquitous enzymes present in nature and are widely used for the
Dan-Dan Wang, Yeon-Ju Kim, Nam In Baek, Ramya Mathiyalagan, Chao Wang, Yan Jin, Xing Yue Xu, Deok-Chun Yang   +7 more
doaj   +1 more source