Antiviral activity of 20(R)-ginsenoside Rh2 against murine gammaherpesvirus [PDF]
Journal of Ginseng Research, 2017 Background: Ginsenosides are the major components of Panax ginseng Meyer, an herbal medicine used for the treatment of various diseases. Different ginsenosides contribute to the biological properties of ginseng, such as antimicrobial, anticancer, and ...
Soowon Kang +3 more
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The potential inhibitory effect of ginsenoside Rh2 on mitophagy in UV-irradiated human dermal fibroblasts [PDF]
Journal of Ginseng Research, 2022 Background: In addition to its use as a health food, ginseng is used in cosmetics and shampoo because of its extensive health benefits. The ginsenoside, Rh2, is a component of ginseng that inhibits tumor cell proliferation and differentiation, promotes ...
Hyunji Lee +3 more
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Ginsenoside Rh2 mitigates myocardial damage in acute myocardial infarction by regulating pyroptosis of cardiomyocytes [PDF]
Clinical and Experimental Hypertension, 2023 Background Acute myocardial infarction (AMI) is one of the most important causes of mortality among patients with cardiovascular disease. Ginsenoside Rh2 plays a protective role in cardiovascular diseases.
Hong Peng +4 more
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The interaction of serum albumin with ginsenoside Rh2 resulted in the downregulation of ginsenoside Rh2 cytotoxicity [PDF]
Journal of Ginseng Research, 2017 Ginsenoside Rh2 (G-Rh2) is a ginseng saponin that is widely investigated because of its remarkable antitumor activity. However, the molecular mechanism by which (20S) G-Rh2 triggers its functions and how target animals avoid its cytotoxic action remains largely unknown.Phage display was used to screen the human targets of (20S) G-Rh2.
Lin, Yingjia +4 more
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AMP-activated protein kinase determines apoptotic sensitivity of cancer cells to ginsenoside-Rh2 [PDF]
Journal of Ginseng Research, 2014 Ginseng saponins exert various important pharmacological effects with regard to the control of many diseases, including cancer. In this study, the anticancer effect of ginsenosides on human cancer cells was investigated and compared.
Min-Jung Kim +6 more
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A stereo-selective growth inhibition profile of ginsenoside Rh2 on human colon cancer cells [PDF]
CyTA - Journal of Food, 2019 We compared the stereo-selective growth inhibition effects of purified enantiomeric pairs of ginsenoside Rh2 (20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2) on human colon cancer cells in vitro with non-invasive real-time cellular analysis. When 50 μM,
Yunju Jeong +3 more
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Comparative analysis of the expression level of recombinant ginsenoside-transforming β-glucosidase in GRAS hosts and mass production of the ginsenoside Rh2-Mix. [PDF]
PLoS ONE, 2017 The ginsenoside Rh2, a pharmaceutically active component of ginseng, is known to have anticancer and antitumor effects. However, white ginseng and red ginseng have extremely low concentrations of Rh2 or Rh2-Mix [20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3].
Muhammad Zubair Siddiqi +5 more
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Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics. [PDF]
PLoS ONE, 2012 Chirality is an interesting topic and it is meaningful to explore the interactions between chiral small molecules and stereoselective biomacromolecules, with pre-clinical and clinical significances.
Jingwei Zhang +6 more
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Effect of Ginsenoside-Rh2 and Curcurbitacin-B on Cryptosporidium parvum in vitro [PDF]
Experimental Parasitology, 2020 Ginsenoside-Rh2 and cucurbitacin-B (CuB) are secondary metabolites of Ginseng (Panax ginseng) and Cucurbitaceae plants respectively. We assessed the anticryptosporidial activity of these two functional compounds in a cell culture model of cryptosporidiosis.
Md, Shahiduzzaman +2 more
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How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured Cells and Obese Mice? [PDF]
Molecules, 2020 Ginsenoside Rh2, an intermediate metabolite of ginseng, but not naturally occurring, has recently drawn attention because of its anticancer effect. However, it is not clear if and how Rh2 inhibits preadipocytes differentiation.
Longyun Zhang +2 more
doaj +3 more sources