Antiviral activity of 20(R)-ginsenoside Rh2 against murine gammaherpesvirus
Journal of Ginseng Research, 2017 Background: Ginsenosides are the major components of Panax ginseng Meyer, an herbal medicine used for the treatment of various diseases. Different ginsenosides contribute to the biological properties of ginseng, such as antimicrobial, anticancer, and ...
Soowon Kang +3 more
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The potential inhibitory effect of ginsenoside Rh2 on mitophagy in UV-irradiated human dermal fibroblasts. [PDF]
J Ginseng Res, 2022 Background: In addition to its use as a health food, ginseng is used in cosmetics and shampoo because of its extensive health benefits. The ginsenoside, Rh2, is a component of ginseng that inhibits tumor cell proliferation and differentiation, promotes ...
Lee H, Kong G, Park J, Park J.
europepmc +2 more sources
Ginsenoside Rh2 Suppresses the Fanconi Anemia Pathway by Inhibiting NF-κB-Mediated FANCL Transcription in Bladder Cancer. [PDF]
Dose ResponseObjectives Cisplatin, a frontline chemotherapeutic agent for bladder cancer (BC), induces DNA interstrand crosslinks that are primarily repaired through the Fanconi anemia (FA) pathway.
Li C, Lv G, Xiong Z, Wang Z.
europepmc +2 more sources
Ginsenoside Rh2-Based Multifunctional Liposomes for Advanced Breast Cancer Therapy. [PDF]
Int J NanomedicineMost solid tumors are not diagnosed and treated until the advanced stage, in which tumors have shaped mature self-protective power, leading to off-target drugs and nanomedicines. In the present studies, we established a more realistic large tumor model to test the antitumor activity of a multifunctional ginsenoside Rh2-based liposome system (Rh2-lipo ...
Hong C +10 more
europepmc +4 more sources
Role of ginsenoside Rh2 in tumor therapy and tumor microenvironment immunomodulation
Biomedicine & Pharmacotherapy, 2022 Ginsenoside Rh2 (Rh2), the major bio-active ginsenoside that originated from the root of Panax ginseng, has become a "hot topic" for playing multifunctional roles in both tumor treatment and tumor microenvironment (TME) immunomodulation. Up to now, emerging experimental research about Rh2 in tumor therapy and immuno-regulation has been published ...
Sun, Xiaodan, Cheng, Ying
openaire +4 more sources
Ginsenoside Rh2 Inhibits NLRP3 Inflammasome Activation and Improves Exosomes to Alleviate Hypoxia-Induced Myocardial Injury. [PDF]
Front Immunol, 2022 The inflammatory microenvironment after acute myocardial infarction (MI) is a key limiting factor in the clinical application of stem cell transplantation and paracrine exosome therapy.
Qi Z +8 more
europepmc +2 more sources
(20S) Ginsenoside Rh2 Inhibits STAT3/VEGF Signaling by Targeting Annexin A2. [PDF]
Int J Mol Sci, 2021 Signal transducers and activators of transcription 3 (STAT3) acts as a transcriptional signal transducer, converting cytokine stimulation into specific gene expression. In tumor cells, aberrant activation of the tyrosine kinase pathway leads to excessive and continuous activation of STAT3, which provides further signals for tumor cell growth and ...
Wang YS, Chen C, Zhang SY, Li Y, Jin YH.
europepmc +4 more sources
Network Pharmacology-Based Prediction and Verification of Ginsenoside Rh2-Induced Apoptosis of A549 Cells via the PI3K/Akt Pathway. [PDF]
Front Pharmacol, 2022 Ginsenoside Rh2 (G-Rh2), a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity.
Song C +8 more
europepmc +2 more sources
Ginsenoside Rh2 Ameliorates Neuropathic Pain by inhibition of the miRNA21-TLR8-mitogen-activated protein kinase axis. [PDF]
Mol Pain, 2022 Ginsenoside Rh2 is one of the major bioactive ginsenosides in Panax ginseng . Although Rh2 is known to enhance immune cells activity for treatment of cancer, its anti-inflammatory and neuroprotective effects have yet to be determined.
Fu YY +5 more
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Journal of Ginseng Research, 2018 Background: Ginsenoside Rh2 has been known to enhance the activity of immune cells, as well as to inhibit the growth of tumor cells. Although the repertoire of genes regulated by Rh2 is well-known in many cancer cells, the epigenetic regulation has yet ...
Hyunkyung Lee +3 more
doaj +3 more sources