Results 41 to 50 of about 2,941 (150)

Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-kappaB, NFATc1 and c-Fos

, 2012
Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation.
Long He, S H Lee, M H Nan, Nak Kyun Soung, Jong Seog Ahn, J Lee, B C Oh, Sangku Lee, Jae-Hyuk Jang, Bo Yeon Kim, H H Kim   +10 more
core   +1 more source

Phytochemicals and Health Benefits of American Ginseng (Panax quinquefolius L.): Current Knowledge and Future Perspectives

Food Safety and Health, EarlyView.
This review summarizes the chemical constituents and functional characteristics of American ginseng, aiming to provide references for its development and application. ABSTRACT American ginseng, a perennial herbaceous plant, is recognized for its significant medicinal properties and has attracted considerable attention due to its diverse phytochemical ...
Wei Geng, Ning Zhou, Jinqian Yu, Yanling Geng, Xiao Wang, Yannan Chen   +5 more
wiley   +1 more source

20 (S)-Ginsenoside-Rh2 and 20 (R)-Ginsenoside-Rh2 Activate IkappaB Phosphorylation Expression in Human Lung Adenocarcinoma A549 Cells

, 2011
To study the underlying mechanism of 20 (S)-Ginsenoside-Rh2 and 20 (R)-Ginsenoside-Rh2 inducing apoptosis of human lung adenocarcinoma A549 cells.
Hai Tao Yu, Chun Jing Zhang, Xiao Dan Qi, Jin Cai Hou   +3 more
core   +1 more source

Additional file 1 of Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity

, 2022
Additional file 1: Characterization of Au@ginsenoside Rh2 NPs and results of cell uptake and cell ...
Yongri Jin (5209676), Zhenhong Wei (433039), Xuwen Li (4872319), Jing Li (10611), Xupeng Mu (5811020), Hua Yao (640790), Jinlan Jiang (228637), Liya Wu (12280409), Xiuying Li (2328508)   +8 more
core   +1 more source

Assessment of a New Ginsenoside Rh2 Nanoniosomal Formulation for Enhanced Antitumor Efficacy on Prostate Cancer: An in vitro Study

Drug Design, Development and Therapy, 2020
Hadi Zare-Zardini,1– 3 Ashraf Alemi,4 Asghar Taheri-Kafrani,5 Seyed Ahmad Hosseini,6 Hossein Soltaninejad,7,8 Amir Ali Hamidieh,9 Mojtaba Haghi Karamallah,10 Majid Farrokhifar,11 Mohammad Farrokhifar12 1Hematology and Oncology Research Center ...
Zare-Zardini H, Alemi A, Taheri-Kafrani A, Hosseini SA, Soltaninejad H, Hamidieh AA, Haghi Karamallah M, Farrokhifar M, Farrokhifar M   +8 more
doaj  

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Biocatalysis for Rare Ginsenoside Rh2 Production in High Level with Co-Immobilized UDP-Glycosyltransferase Bs-YjiC Mutant and Sucrose Synthase AtSuSy

, 2021
Rare ginsenoside Rh2 exhibits diverse pharmacological effects. UDP-glycosyltransferase (UGT) catalyzed glycosylation of protopanaxadiol (PPD) has been of growing interest in recent years.
Jianlin Chu, Jiheng Yue, Yuqiang Li, Bingfang He, Bin Wu, Song Qin   +5 more
core   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, Volume 13, Issue 34, 19 June 2026.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2

Frontiers in Pharmacology, 2022
Aim: The 20(S)-ginsenoside Rh2 (Rh2) is being developed as a new antitumor drug. However, to date, little is known about the kinetics of its deglycosylation metabolite (protopanoxadiol) (PPD) following Rh2 administration.
Hong-can Ren, Hong-can Ren, Hong-can Ren, Jian-guo Sun, Ji-ye A, Sheng-hua Gu, Sheng-hua Gu, Jian Shi, Jian Shi, Feng Shao, Hua Ai, Jing-wei Zhang, Ying Peng, Bei Yan, Qing Huang, Qing Huang, Lin-sheng Liu, Lin-sheng Liu, Yang Sai, Guang-ji Wang, Cheng-guang Yang   +20 more
doaj   +1 more source

The Supporting Role of Natural Products as Effective Adjuvants in Cancer Immunotherapy

eFood, Volume 7, Issue 3, June 2026.
Natural products, as multi‐target and low‐toxicity adjuvants, enhance immune checkpoint inhibitor responses and reduce immune‐related adverse events through T cell reprogramming, microenvironment remodeling, and microbiota‐immune modulation. ABSTRACT Immune checkpoint inhibitors (ICIs) have revolutionized the treatment landscape of malignant tumors ...
Boyang Liu, Yubin Huang, Jianjun Deng, Zhijun Mao, Xue Bai, Longyang Ma, Jianhua Wang   +6 more
wiley   +1 more source