Results 41 to 50 of about 3,001 (186)

EGFR-Targeted Liposomes Combined with Ginsenoside Rh2 Inhibit Triple-Negative Breast Cancer Growth and Metastasis [PDF]

, 2023
Triple-negative breast cancer (TNBC) remains the most challenging breast cancer subtype due to its lack of targeted therapies and poor prognosis. In order to treat patients with these tumors, efforts have been made to explore feasible targets.
Aiguo Wu (315321), Canxin Xu (3847465), Aiguo Wu, Yuanbo Pan, Rui Shi, Chen Xu (53797), Wenhao Lv (10914291), Xueyin Hu, Xueyin Hu (14034184), Wenhao Lv, Chen Xu, Canxin Xu, Juan Li, Haiyan Gu, Xiahong He, Rui Shi (45165), Xiahong He (369038), Juan Li (146180), Haiyan Gu (9726796), Yuanbo Pan (14034181)   +19 more
core   +1 more source

Ginsenoside Rh2 inhibits osteoclastogenesis through down-regulation of NF-kappaB, NFATc1 and c-Fos [PDF]

, 2012
Ginsenoside Rh2 is one of the most active components of red ginseng, controlling cancer and other metabolic diseases including osteoclast differentiation.
Long He, S H Lee, M H Nan, Nak Kyun Soung, Jong Seog Ahn, J Lee, B C Oh, Sangku Lee, Jae-Hyuk Jang, Bo Yeon Kim, H H Kim   +10 more
core   +1 more source

Induction of apoptosis in prostate cancer by ginsenoside Rh2

Oncotarget, 2018
The therapeutic action of ginsenoside Rh2 on several cancer models has been reported. This study aimed to evaluate its apoptotic effect on prostate cancer and the underlying mechanism. Cultured DU145 cells were treated with Rh2 (5 × 10-5 to 1 × 10-4 M), peroxisome proliferator-activated receptor-delta (PPAR-delta) antagonist GSK0660 (1 × 10-6 to 5 × 10-
Tong-Lin Wu, Tony, Tong, Yat-Ching, Chen, I-Hung, Niu, Ho-Shan, Li, Yingxiao, Cheng, Juei-Tang   +5 more
openaire   +3 more sources

(20S) Ginsenoside Rh2 Inhibits STAT3/VEGF Signaling by Targeting Annexin A2. [PDF]

Int J Mol Sci, 2021
Signal transducers and activators of transcription 3 (STAT3) acts as a transcriptional signal transducer, converting cytokine stimulation into specific gene expression. In tumor cells, aberrant activation of the tyrosine kinase pathway leads to excessive
Wang YS, Chen C, Zhang SY, Li Y, Jin YH.
europepmc   +2 more sources

Additional file 1 of Facile approach for surfactant-free synthesis of Au@ginsenoside Rh2 nanoparticles and researches on anticancer activity [PDF]

, 2022
Additional file 1: Characterization of Au@ginsenoside Rh2 NPs and results of cell uptake and cell ...
Yongri Jin (5209676), Zhenhong Wei (433039), Xuwen Li (4872319), Jing Li (10611), Xupeng Mu (5811020), Hua Yao (640790), Jinlan Jiang (228637), Liya Wu (12280409), Xiuying Li (2328508)   +8 more
core   +1 more source

Biocatalysis for Rare Ginsenoside Rh2 Production in High Level with Co-Immobilized UDP-Glycosyltransferase Bs-YjiC Mutant and Sucrose Synthase AtSuSy [PDF]

, 2021
Rare ginsenoside Rh2 exhibits diverse pharmacological effects. UDP-glycosyltransferase (UGT) catalyzed glycosylation of protopanaxadiol (PPD) has been of growing interest in recent years.
Jianlin Chu, Jiheng Yue, Yuqiang Li, Bingfang He, Bin Wu, Song Qin   +5 more
core   +1 more source

Inhibition of prostatic cancer growth by ginsenoside Rh2

Tumor Biology, 2014
Ginsenoside Rh2 (GRh2) has been reported to have therapeutic effects on some types of cancer, but its effect on prostatic cancer has not been extensively evaluated. Here, we show that GRh2 can substantially inhibit the growth of prostatic cancer in vivo and in vitro.
Qingchuan, Zhang, Bin, Hong, Songhua, Wu, Tianli, Niu   +3 more
openaire   +2 more sources

Ginsenoside Rh2 Mitigates Endoplasmic Reticulum Stress-Induced Apoptosis and Inflammation and Through Inhibition of Hepatocyte-Macrophage Inflammatory Crosstalk. [PDF]

Nutrients
Background/Objectives: Endoplasmic reticulum stress (ERS) contributes to hepatocyte inflammation, triggered by prolonged exposure to lipotoxicity, and promotes non-alcoholic fatty liver disease (NAFLD) progression by recruiting and activating hepatic ...
Park S, Jeong I, Kim OK.
europepmc   +2 more sources

Inhibition of macrophage polarization and pyroptosis in collagen-induced arthritis through MSC-exo and ginsenoside Rh2. [PDF]

Arthritis Res Ther
Background Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation, tissue damage, and fibrosis, significantly affecting the quality of life.
Zhou Z, Wu S, Li Y, Shao P, Jiang J.
europepmc   +2 more sources

Role of ginsenoside Rh2 in tumor therapy and tumor microenvironment immunomodulation

Biomedicine & Pharmacotherapy, 2022
Ginsenoside Rh2 (Rh2), the major bio-active ginsenoside that originated from the root of Panax ginseng, has become a "hot topic" for playing multifunctional roles in both tumor treatment and tumor microenvironment (TME) immunomodulation. Up to now, emerging experimental research about Rh2 in tumor therapy and immuno-regulation has been published ...
Sun, Xiaodan, Cheng, Ying
openaire   +2 more sources