Efficacy and safety of ginsam, a vinegar extract from Panax ginseng, in type 2 diabetic patients: Results of a double‐blind, placebo‐controlled study [PDF]
, 2014 Aims/Introduction: The efficacy, dose–response relationship and safety of ginsam, a vinegar extract from Panax ginseng, were evaluated in an 8‐week, double‐blind, randomized, placebo‐controlled study in drug‐naïve patients with type 2 diabetes. Materials
Ahn, Hwa Young +9 more
core +1 more source
Induction of apoptosis in prostate cancer by ginsenoside Rh2
Oncotarget, 2018 The therapeutic action of ginsenoside Rh2 on several cancer models has been reported. This study aimed to evaluate its apoptotic effect on prostate cancer and the underlying mechanism. Cultured DU145 cells were treated with Rh2 (5 × 10-5 to 1 × 10-4 M), peroxisome proliferator-activated receptor-delta (PPAR-delta) antagonist GSK0660 (1 × 10-6 to 5 × 10-
Tong-Lin Wu, Tony +5 more
openaire +3 more sources
Medicinal Plants with Multiple Effects on Diabetes Mellitus and Its Complications: a Systematic Review [PDF]
, 2018 Purpose of Review This systematic review describes evidence concerning medicinal plants that, in addition to exerting hypoglycemic effects, decrease accompanying complications such as nephropathy, neuropathy, retinopathy, hypertension, and/or ...
Lorigooini, Zahra. +3 more
core +6 more sources
Preparation and Characterization of a Standardized Anticonvulsant Ginseng Rb Extract from Panax quinquefolius L. [PDF]
, 2011 A ginseng Rb extract (GRbE) containing three major ingredients of ginsenoside Rb1 (G-Rb1), ginsenoside Rb3 (G-Rb3) and ginsenoside Rd (G-Rd) has been shown to have anticonvulsant and neuroprotective activity.
Lian, Xiao-Yuan, Zhang, Zhizhen
core +2 more sources
Pharmacologically relevant drug interactions of sulfonylurea antidiabetics with common herbs [PDF]
, 2018 Introduction: Sulfonylurea antidiabetics are insulin secretogogues useful in the treatment of type 2 diabetic patients. The probability of adverse drug interactions is high in patients taking sulfonylureas and other drugs including herbal medicines ...
Balasubramaniam, Rajkapoor. +1 more
core +2 more sources
Anticancer activity of ginsenosides Rh2 on various cancer cells
Journal of Animal Reproduction and Biotechnology, 2023 Background: This study has mainly focused on finding pharmacological effects of ginsenosides that can reduce the unwanted side effects of the cytotoxic anticancer drugs and are highly effective on prostate cancer, colorectal cancer, liver cancer, hormone-dependent breast cancer, triple-negative breast cancer, and brain cancer (neuroblastoma).
Seun Eui Kim +6 more
openaire +2 more sources
Ginsenosides act as positive modulators of P2X4 receptors [PDF]
, 2018 We investigated the selectivity of protopanaxadiol ginsenosides from Panax ginseng acting as positive allosteric modulators on P2X receptors. ATP-induced responses were measured in stable cell lines overexpressing human P2X4 using a YOPRO-1 dye uptake ...
Asatryan +23 more
core +3 more sources
Transcriptome Analyses of the Anti-Proliferative Effects of 20(S)-Ginsenoside Rh2 on HepG2 Cells
Frontiers in Pharmacology, 2019 20(S)-ginsenoside Rh2 (Rh2), a well-known protopanaxadiol-type ginsenoside from Panax ginseng has especially gained attention for its anticancer activities on various types of human cancer cells.
Ji Zhang +7 more
doaj +1 more source
Snailase Preparation of Ginsenoside M1 from Protopanaxadiol-Type Ginsenoside and Their Protective Effects Against CCl4-Induced Chronic Hepatotoxicity in Mice [PDF]
, 2011 To investigate the protective effects of protopanaxadiol-type ginsenoside (PDG) and its metabolite ginsenoside M1 (G-M1) on carbon tetrachloride (CCl4)-induced chronic liver injury in ICR mice, we carried out conversion of protopanaxadiol-type ...
Hui Wang +9 more
core +2 more sources
The effects of Ginsenosides on PI3K/AKT signaling pathway [PDF]
, 2022 Ginsenosides belong to a group of steroid glycosides that are extracted from the plant genus Panax (ginseng). This plant has been used for a long time for the treatment of a variety of disorders in traditional medicine.
Ayatollahi, Seyed Abdulmajid +7 more
core +1 more source