Results 71 to 80 of about 2,941 (150)

Integrating Traditional Wisdom With Modern Science: Ginsenosides as Antiheart Failure Agents

Cardiovascular Therapeutics, Volume 2026, Issue 1, 2026.
Heart failure (HF), as the terminal stage of various cardiovascular diseases, remains a global health challenge with persistently high morbidity and mortality rates. Although current therapies—including angiotensin receptor–neprilysin inhibitors, sodium‐glucose cotransporter‐2 inhibitors, and cardiac resynchronization therapy—have improved outcomes ...
Li Zhou, Yanhua Li, Wenjie Yin, Xi Gu, Jiana Shi, Fan Yang, Satabdi Datta Choudhury   +6 more
wiley   +1 more source

Ginsenoside Rb1 is transformed into Rd and Rh2 by Microbacterium trichothecenolyticum

, 2013
Ginsenosides are the most important ingredient of ginseng and are known to possess many pharmacological and biological effects. Rb1, a major protopanaxadiol ginsenoside, is the most abundant ginsenoside in Panax ginseng C.A Meyer and can be hydrolyzed ...
Byoung Chul Park, H Kim, H Shin, Phil Young Lee, Kwang-Hee Bae, S Cho, Sung Goo Park, J H Kim   +7 more
core   +1 more source

The Roles of MicroRNAs, Oncogenes, and Tumor Suppressor Gene Molecular Subtypes of Breast Cancer: Therapeutic Potential of Pharmaceutical and Natural Products

International Journal of Breast Cancer, Volume 2026, Issue 1, 2026.
Background Breast cancer (BC) is the most common malignancy among women, with 2.3 million new cases and over 670,000 deaths annually. Despite advances in detection and therapy, relapse, metastasis, and resistance remain significant challenges. Tumor suppressor genes (TSGs) regulate abnormal cell division, whereas oncogenes, which arise from proto ...
Md. Sadikuj Jaman, Md. Maniruzzaman, Md. Rokibul Hasan Bhuiyan, Md Shajedul Haque, Irfan Ahmad   +4 more
wiley   +1 more source

Hepatoprotective Effects of Cipollotto Nocerino Leaf Extract in HepG2 Cells: SIRT1‐Mediated Regulation of Lipid Metabolism and Oxidative Stress

Journal of Food Biochemistry, Volume 2026, Issue 1, 2026.
Cipollotto Nocerino (Allium cepa L.), a Protected Designation of Origin (PDO) spring onion from the Campania region (Southern Italy), yields leaves that are a neglected agri‐food by‐product, typically discarded despite their rich phytochemical profile, and remain largely unexplored, particularly regarding their potential to counteract hepatic steatosis.
Maria Rosaria Miranda, Giovanna Aquino, Tania Ciaglia, Giuseppina Amodio, Manuela Giovanna Basilicata, Mario Felice Tecce, Vincenzo Vestuto, Pietro Campiglia, Michele Manfra, Giacomo Pepe, Anupama Bose   +10 more
wiley   +1 more source

Optimization of Fermentation Process of Panax quinquefolius L. by Schizophyllum commune and Its Antioxidant Capacity in Vitro

Shipin gongye ke-ji
In order to improve the economic value of Panax quinquefolius L., this study used Panax quinquefolius L. as raw material to solid state ferment Panax quinquefolius L.
Kunlun WANG, Lijun GUAN, Yang GAO, Song YAN, Jialei LI, Nina JI, Bo LI, Ye ZHOU   +7 more
doaj   +1 more source

Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro

Food and Agricultural Immunology, 2018
Breast cancer is the most common cancer in women worldwide. The antiproliferative activities of protopanaxatiol (PPT) and ginsenoside Rh2 was measured by evaluating the inhibition of MDA-MB-231 human breast cancer cell proliferation.
Guixing Ren, Caie Wu, Cong Teng, Yang Yao   +3 more
doaj   +1 more source

Lipid Autophagy: An Idea for the Treatment of Diabetic Nephropathy With Ginseng and Its Active Compounds

eFood, Volume 6, Issue 6, December 2025.
In light of the steadily increasing incidence of diabetic nephropathy (DN), this review explores the potential of edible natural products to slow disease progression, addressing the limitations of conventional clinical drug therapies. Key findings show that ginsenosides, the active compounds in edible ginseng, regulate lipid autophagy, reducing ...
Rui Zhang, Xushan Lan, Chenguang Wu, Jingjing Wang, Chengqian Yin, Lifan Wang, Peng Liu, Ping Li   +7 more
wiley   +1 more source

Evaluation of glucosidases of Aspergillus niger strain comparing with other glucosidases in transformation of ginsenoside Rb1 to ginsenosides Rg3

Journal of Ginseng Research, 2014
The transformation of ginsenoside Rb1 into a specific minor ginsenoside using Aspergillus niger KCCM 11239, as well as the identification of the transformed products and the pathway via thin layer chromatography and high performance liquid chromatography
Kyung Hoon Chang, Mi Na Jo, Kee-Tae Kim, Hyun-Dong Paik   +3 more
doaj   +1 more source

(20S) Ginsenoside Rh2 Exerts Its Anti-Tumor Effect by Disrupting the HSP90A-Cdc37 System in Human Liver Cancer Cells

, 2021
(20S) ginsenoside Rh2 (G-Rh2), a major bioactive metabolite of ginseng, effectively inhibits the survival and proliferation of human liver cancer cells. However, its molecular targets and working mechanism remain largely unknown.
Chen Chen, Yang Li, Gang-Ao Li, Ying-Hua Jin, En-Ting Zhang, Wen-Yuan Liu, Yu-Shi Wang   +6 more
core   +1 more source

Membrane cholesterol delays cellular apoptosis induced by ginsenoside RH2, a steroid saponin

, 2018
Saponins exhibit several biological and pharmacological activities, such as antibacterial, anti-inflammatory and anticancer effects. Many studies attribute their activities to their interactions with cholesterol.
Albert, Marie, Donatienne Tyteca, Muccioli, Giulio, Marie Albert, Verstraeten, Sandrine, Paquot, Adrien, Tyteca, Donatienne, Mingeot-Leclercq, Marie-Paule, Giulio G. Muccioli, Sandrine L. Verstraeten, Marie-Paule Mingeot-Leclercq, Adrien Paquot   +11 more
core   +1 more source