Results 61 to 70 of about 3,001 (186)

Traditional Chinese Medicine for lung cancer: Mechanisms, clinical evidence, and future perspectives

Precision Medical Sciences, EarlyView.
Graphical abstract represents the risk factors for lung cancer, TCM efficacy and clinical outcomes to future challenges. Abstract Lung cancer remains a leading cause of global cancer mortality. Despite advances in conventional treatments such as surgery, chemotherapy, targeted therapy, and immunotherapy, challenges including drug resistance, toxicity ...
Zhangdeng Chen, Liujun Bao
wiley   +1 more source

Ginsenoside Rh2 inhibits growth of glioblastoma multiforme through mTor

Tumor Biology, 2014
Being the most malignant primary brain tumor in humans, glioblastoma multiforme (GBM) has a fairly poor patient survival after current combined treatment with chemotherapy, radiation, and surgery. Ginsenoside Rh2 (GRh2) has been reported to have a therapeutic effect on some tumors, and we recently reported its inhibitory effect on GBM growth in vitro ...
Shaoyi, Li, Wenchang, Guo, Yun, Gao, Yunhui, Liu   +3 more
openaire   +2 more sources

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

Targeting CHEK1: Ginsenosides-Rh2 and Cu2O@G-Rh2 nanoparticles in thyroid cancer

Cell Biology and Toxicology
Thyroid cancer (THCA) is an increasingly common malignant tumor of the endocrine system, with its incidence rising steadily in recent years. For patients who experience recurrence or metastasis, treatment options are relatively limited, and the prognosis is poor. Therefore, exploring new therapeutic strategies has become particularly urgent. This study
Wang, Lidong, Wu, Xin, Wang, XinLu, Dong, Meng, Zhang, Hao, Zhao, Pengfei   +5 more
openaire   +2 more sources

Ginsenoside Rh2 Ameliorates Scopolamine-Induced Learning Deficit in Mice

Biological & Pharmaceutical Bulletin, 2009
To understand memory-enhancing effect of red ginseng biotransformed by Bifidobacterium longum H-1 (RGB), which more potently improved scopolamine-induced learning deficit than red ginseng in the preliminary experiment, its main constituents, ginsenosides Rb1, Rg3 and Rh2, were isolated and their memory-enhancing effects investigated in scopolamine ...
Yang, Jung-Hwa, Han, Sang-Jun, Ryu, Jong Hoon, Jang, Il-Sung, Kim, Dong-Hyun   +4 more
openaire   +3 more sources

Therapeutic Properties and Underlying Mechanisms of Traditional Chinese Medicine in Managing Rheumatoid Arthritis: An Integrative Review of Clinical and Molecular Findings

Phytotherapy Research, EarlyView.
The translational research framework integrating TCM for RA. The figure outlines a stepwise framework for the modernization and clinical translation of TCM in RA. Part 1 highlights the inheritance and development of TCM theory, including classical medical texts, traditional herbal knowledge, and syndrome differentiation–based treatment principles. Part
Jianting Wen, Jian Liu, Lei Wan, Fanfan Wang, Yang Li   +4 more
wiley   +1 more source

Anticancer activity of ginsenosides Rh2 on various cancer cells

Journal of Animal Reproduction and Biotechnology, 2023
Background: This study has mainly focused on finding pharmacological effects of ginsenosides that can reduce the unwanted side effects of the cytotoxic anticancer drugs and are highly effective on prostate cancer, colorectal cancer, liver cancer, hormone-dependent breast cancer, triple-negative breast cancer, and brain cancer (neuroblastoma).
Seun Eui Kim, Myoung-Hoon Lee, Hye-Myoung Jang, Wan-Taek Im, Joontaik Lee, Sang-Hwan Kim, Gwang Joo Jeon   +6 more
openaire   +2 more sources

EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2

Tumor Biology, 2014
Glioblastoma is the most common and most aggressive malignant primary brain tumor in humans, accounting for 52 % of all functional tissue brain tumor cases and 20 % of all intracranial tumors. The typical treatment involves a combination of chemotherapy, radiation, and surgery, whereas it still achieves fairly poor patient survival. Ginsenoside Rh2 has
Shaoyi, Li, Yun, Gao, Weining, Ma, Wenchang, Guo, Gang, Zhou, Tianci, Cheng, Yunhui, Liu   +6 more
openaire   +2 more sources

Study on Antidepressant Activity of Pseudo-Ginsenoside HQ on Depression-Like Behavior in Mice

Molecules, 2019
Suppressive effects of ginsenoside Rh2 (Rh2), (24R)-pseudo-ginsenoside HQ (R-PHQ), and (24S)-pseudo-ginsenoside HQ (S-PHQ) against lipopolysaccharide (LPS)-induced depression-like behavior were evaluated using the forced swimming test (FST) and tail ...
Li-xue Chen, Zeng Qi, Zi-jun Shao, Shan-shan Li, Yu-li Qi, Kun Gao, Song-xin Liu, Zhuo Li, Yin-shi Sun, Ping-ya Li   +9 more
doaj   +1 more source

Mechanism-Based Pharmacokinetic Model for the Deglycosylation Kinetics of 20(S)-Ginsenosides Rh2

Frontiers in Pharmacology, 2022
Aim: The 20(S)-ginsenoside Rh2 (Rh2) is being developed as a new antitumor drug. However, to date, little is known about the kinetics of its deglycosylation metabolite (protopanoxadiol) (PPD) following Rh2 administration.
Hong-can Ren, Hong-can Ren, Hong-can Ren, Jian-guo Sun, Ji-ye A, Sheng-hua Gu, Sheng-hua Gu, Jian Shi, Jian Shi, Feng Shao, Hua Ai, Jing-wei Zhang, Ying Peng, Bei Yan, Qing Huang, Qing Huang, Lin-sheng Liu, Lin-sheng Liu, Yang Sai, Guang-ji Wang, Cheng-guang Yang   +20 more
doaj   +1 more source