Results 81 to 90 of about 3,001 (186)
Vacuolization as a Novel Approach to Cancer Therapy
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.This review discusses the novel strategy of inducing vacuole formation in cancer cells using small molecules, that induce nonapoptotic cell death mechanisms, such as paraptosis, oncosis, autophagy, and methuosis, and its potential in overcoming resistance to apoptosis‐based cancer therapies.
Mariah Pasternak +9 more
wiley +1 more source
Synthesis of hyaluronic acid or O-carboxymethyl chitosan-stabilized ZnO–ginsenoside Rh2 nanocomposites incorporated with aqueous leaf extract of Dendropanax morbifera Léveille: in vitro studies as potential sunscreen agents [PDF]
, 2019 The present study elucidates the synthesis of hyaluronic acid (HA) or O-carboxymethyl chitosan (CMC)-stabilized zinc oxide nanocomposites (ZnONcs) incorporated with aqueous leaf extract of Dendropanax morbifera Leveille to enhance the water solubility of
Mathiyalagan, Ramya +6 more
core +1 more source
Cancer Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background Bladder cancer (BCa) is the most common and representative type of adult urinary tract urothelial cancer, characterized by high incidence and mortality rates. It has become a major disease threatening public health, highlighting the urgent need for the development of comprehensive treatment strategies, including traditional Chinese ...
Di Liu, Qing‐Yu Zhang
wiley +1 more source
Zhongliu Fangzhi YanjiuObjectiveTo explore the effects of exosomes loaded with ginsenoside Rh2 on the biological functions of hepatocellular carcinoma cells. MethodsBoth Huh7 and PLC/PRF/5 cell were equally divided into control group, exosome group (Exos group), drug group (G ...
Meile LI +3 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 3, May 2026.This review aims to provide a comprehensive understanding of the therapeutic potential of bioactive anticancer phytoconstituents in Panax ginseng, including their clinical aspects and SAR, thereby fostering the development of newer anticancer compounds for cancer management.
Akrit Verma +2 more
wiley +1 more source
Ginsenoside Rh2 Induces Human Hepatoma Cell Apoptosisvia Bax/Bak Triggered Cytochrome C Release and Caspase-9/Caspase-8 Activation [PDF]
, 2012 Ginsenoside Rh2 (G-Rh2) has been shown to induce apoptotic cell death in a variety of cancer cells. However, the details of the signal transduction cascade involved in G-Rh2-induced cell death is unclear.
Yang Li +5 more
core +1 more source
Targeting Autophagy in Ovarian Cancer: The Emerging Role of Ginsenosides
Cancer Medicine, Volume 15, Issue 3, March 2026.ABSTRACT Background Ovarian cancer, the third most prevalent gynecological malignancy, is frequently diagnosed at an advanced stage owing to its asymptomatic early progression. Despite the application of conventional therapies, clinical management remains limited by adverse effects and the development of drug resistance.
Yuxin Guo +4 more
wiley +1 more source
Tailored biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme [PDF]
, 2017 With the development of synthetic biology, substantial progress has been made in the low-cost production of plant natural products in microbes. Ginsenoside Rh2 is a potential anticancer drug isolated from medicinal plant ginseng.
Feng, Yan +3 more
core +1 more source
Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets
MedComm, Volume 7, Issue 3, March 2026.This schematic illustrates the central role of lactylation, a lactate‐derived posttranslational modification, in linking metabolic reprogramming to cancer progression and therapy resistance. At its core, lactylation modulates proteins, influenced by metabolic shifts and environmental factors.
Qianying Ouyang +10 more
wiley +1 more source
Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells [PDF]
, 2018 Matrix metalloproteinases (MMPs) play an important role in glioma infiltration, facilitating cell migration and tumor invasion through their ability to degrade the extracellular matrix.
김희선
core +1 more source