Results 91 to 100 of about 2,941 (150)

Repression of matrix metalloproteinase gene expression by ginsenoside Rh2 in human astroglioma cells

, 2018
Matrix metalloproteinases (MMPs) play an important role in glioma infiltration, facilitating cell migration and tumor invasion through their ability to degrade the extracellular matrix.
김희선
core   +1 more source

The identification of molecular target of (20S) ginsenoside Rh2 for its anti-cancer activity

, 2017
The 20S ginsenoside Rh2 (G-Rh2) effectively inhibits cancer cell growth and survival in both animal models and cell lines. However, its molecular targets and mechanism of action remain largely unknown. By screening for molecules that interact with (20S)G-
Yingjia Lin, Yang Li, He Li, Ying-Hua Jin, Yu-Shi Wang, Zhiguang Song   +5 more
core   +1 more source

A multicomponent microemulsion using rational combination strategy improves lung cancer treatment through synergistic effects and deep tumor penetration

Drug Delivery, 2017
Previously, we have developed a multicomponent-based microemulsion composed of etoposide, coix seed oil, and ginsenoside Rh2 (ECG-MEs). In this study, our goal was to validate the feasibility of ECG-MEs in lung cancer treatment and explore the mechanism ...
Ding Qu, Mengfei Guo, Yue Qin, Lixiang Wang, Bing Zong, Yunyan Chen, Yan Chen   +6 more
doaj   +1 more source

Remodeling the tumor immune microenvironment through hydrogel encapsulated G-Rh2 in situ vaccine and systemic immunotherapy

Materials Today Bio
Ginsenoside Rh2 (G-Rh2) is a vital bioactive compound in Traditional Chinese Medicine, celebrated for its strong pharmacological properties, particularly its potent antitumor effects.
Chunhua Li, Dan Lei, Yudong Huang, Yuanhao Jing, Wanru Wang, Lanqi Cen, Zijian Wei, Anni Chen, Xiaoyu Feng, Yushu Wang, Lixia Yu, Ying Chen, Rutian Li   +12 more
doaj   +1 more source

Ginsenosides Rg3 and Rh2 inhibit the activation of AP-1 and protein kinase A pathway in lipopolysaccharide/interferon-γ-stimulated BV-2 microglial cells

, 2018
The anti-inflammatory effect of ginsenosides Rg3 and Rh2, which improves ischemic brain injury induced by middle cerebral artery occlusion, was investigated in lipopolysaccharide (LPS) and IFN-γ-induced murine BV-2 microglial cells.
김희선
core   +1 more source

Mediation of Beta-Endorphin by Ginsenoside Rh2 to Lower Plasma Glucose in Streptozotocin-Induced Diabetic Rats

, 2009
We investigated the plasma glucose-lowering mechanism(s) of Rh2, a ginsenoside derived from Panax ginseng, in rats with streptozotocin- induced diabetes (STZ-diabetic rats).
LAI, DAR-MING;TU, YONG-KWANG;LIU, I-MIN;CHENG, JUEI-TANG, 賴達明;杜永光;劉怡旻;鄭瑞堂   +1 more
core  

Structural Insights into the Substrate Recognition of Ginsenoside Glycosyltransferase Pq3‐O‐UGT2

Advanced Science
Ginsenosides are a group of tetracyclic triterpenoids with promising health benefits, consisting of ginseng aglycone attached to various glycans. Pq3‐O‐UGT2, an important UDP‐dependent glycosyltransferase (UGT), catalyzes the production of Ginsenoside ...
Qiushuang Ji, Yirong Liu, Huanyu Zhang, Yan Gao, Yixin Ding, Yuanyuan Ding, Jing Xie, Jianyu Zhang, Xinghua Jin, Bin Lai, Cheng Chen, Juan Wang, Wenyuan Gao, Kunrong Mei   +13 more
doaj   +1 more source

The potential mechanism of Aidi injection against neuroblastoma—an investigation based on network pharmacology analysis

Frontiers in Pharmacology
Background: Aidi injection, a classic traditional Chinese medicine (TCM) formula, has been used on a broader scale in treating a variety of cancers. In this study, we aimed to explore the potential anti-tumor effects of Aidi injection in the treatment of
Shuyang Dai, Yaoyao Gu, Yong Zhan, Jie Zhang, Lulu Xie, Yi Li, Yifei Lu, Ran Yang, Enqing Zhou, Deqian Chen, Songbin Liu, Shan Zheng, Zhaopeng Shi, Kuiran Dong, Rui Dong   +14 more
doaj   +1 more source

A novel autophagy activator ginsenoside Rh2 enhances the efficacy of immunogenic chemotherapy. [PDF]

Clin Transl Med, 2023
Yang J, Zhang W, Jia L, Shi F, Cao M, Sun J, Xu C, Li Z, Cheng Z, Zhao SC, Wang J, Yang C.   +11 more
europepmc   +1 more source

Influence of Ginsenoside Rh2 on Cardiomyocyte Pyroptosis in Rats with Acute Myocardial Infarction. [PDF]

Evid Based Complement Alternat Med, 2022
Song W, Dai B, Dai Y.
europepmc   +1 more source