Results 11 to 20 of about 51,391 (176)
Stereoselective regulations of P-glycoprotein by ginsenoside Rh2 epimers and the potential mechanisms from the view of pharmacokinetics. [PDF]
PLoS ONE, 2012 Chirality is an interesting topic and it is meaningful to explore the interactions between chiral small molecules and stereoselective biomacromolecules, with pre-clinical and clinical significances.
Jingwei Zhang +6 more
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Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2
Molecules, 2022 Ginsenoside Rh2 increases the efficacy of doxorubicin (DOX) treatment in murine models of solid and ascites Ehrlich’s adenocarcinoma. In a solid tumor model (treatment commencing 7 days after inoculation), DOX + Rh2 co-treatment was significantly more ...
Alexander Popov +14 more
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How Does Ginsenoside Rh2 Mitigate Adipogenesis in Cultured Cells and Obese Mice?
Molecules, 2020 Ginsenoside Rh2, an intermediate metabolite of ginseng, but not naturally occurring, has recently drawn attention because of its anticancer effect. However, it is not clear if and how Rh2 inhibits preadipocytes differentiation.
Longyun Zhang +2 more
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Anticancer activity of ginsenosides Rh2 on various cancer cells
Journal of Animal Reproduction and Biotechnology, 2023 Background: This study has mainly focused on finding pharmacological effects of ginsenosides that can reduce the unwanted side effects of the cytotoxic anticancer drugs and are highly effective on prostate cancer, colorectal cancer, liver cancer, hormone-
Seun Eui Kim +6 more
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Increased antitumor efficacy of ginsenoside Rh2 via mixed micelles: in vivo and in vitro evaluation
Drug Delivery, 2020 The aim of this work is to apply Solutol® HS15 and TPGS to prepare self-assembled micelles loading with ginsenoside Rh2 to increase the solubility of ginsenoside Rh2, hence, improving the antitumor efficacy.
Xiaojing Xia +5 more
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Foods, 2023 Liposomes (Lip) are microstructures containing lipid and aqueous phases for encapsulation and delivery of bioactivators. In this study, Ginsenoside Rh2 liposomes (Rh2−Lip) were prepared by a thin-film hydrated ultrasonic binding method.
Minghui Wang +6 more
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Journal of Ginseng Research, 2021 Background: Ginsenoside Rh2 is well known for many pharmacological activities, such as anticancer, antidiabetes, antiinflammatory, and antiobesity properties. Glycosyltransferases (GTs) are ubiquitous enzymes present in nature and are widely used for the
Dan-Dan Wang +7 more
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Journal of Ginseng Research, 2022 Background: Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is a natural compound extracted from ginseng, which exhibits anticancer effects in many cancer types.
Haibo Zhang +14 more
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Antiallergic Activity of Ginsenoside Rh2
Biological & Pharmaceutical Bulletin, 2003 The antiallergic activities of ginsenosides, which were isolated from acid-treated ginseng (Panax ginseng, Araliaceae), and their metabolites by human intestinal bacteria were measured. Ginsenoside Rh2, which is a main metabolite, had the most potent inhibitory activity on beta-hexosaminidase release from RBL-2H3 cells and in the passive cutaneous ...
Park, Eun-Kyung +4 more
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Frontiers in Pharmacology, 2022 Ginsenoside Rh2 (G-Rh2), a rare protopanaxadiol (PPD)-type triterpene saponin, from Panax ginseng has anti-proliferation, anti-invasion, and anti-metastatic activity.
Chao Song +8 more
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