Results 31 to 40 of about 51,297 (183)

Induction of apoptosis in prostate cancer by ginsenoside Rh2

Oncotarget, 2018
The therapeutic action of ginsenoside Rh2 on several cancer models has been reported. This study aimed to evaluate its apoptotic effect on prostate cancer and the underlying mechanism. Cultured DU145 cells were treated with Rh2 (5 × 10-5 to 1 × 10-4 M), peroxisome proliferator-activated receptor-delta (PPAR-delta) antagonist GSK0660 (1 × 10-6 to 5 × 10-
Tong-Lin Wu, Tony, Tong, Yat-Ching, Chen, I-Hung, Niu, Ho-Shan, Li, Yingxiao, Cheng, Juei-Tang   +5 more
openaire   +3 more sources

Network Pharmacology-Based Study on the Mechanism of Ginsenoside Rh2 in Glioma Treatment

Natural Product Communications, 2022
Glioma, originated from the neuroectoderm, is one of the prevalent tumors. It is reported that ginsenoside Rh2, a compound extracted from Panax ginseng, shows pharmacological activity in inhibiting the proliferation and metastasis of glioma cells ...
Xue Wu, Xiujiao Qin, Han Dong
doaj   +1 more source

Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro

Food and Agricultural Immunology, 2018
Breast cancer is the most common cancer in women worldwide. The antiproliferative activities of protopanaxatiol (PPT) and ginsenoside Rh2 was measured by evaluating the inhibition of MDA-MB-231 human breast cancer cell proliferation.
Guixing Ren, Caie Wu, Cong Teng, Yang Yao   +3 more
doaj   +1 more source

Targeting CHEK1: Ginsenosides-Rh2 and Cu2O@G-Rh2 nanoparticles in thyroid cancer

Cell Biology and Toxicology
Thyroid cancer (THCA) is an increasingly common malignant tumor of the endocrine system, with its incidence rising steadily in recent years. For patients who experience recurrence or metastasis, treatment options are relatively limited, and the prognosis is poor. Therefore, exploring new therapeutic strategies has become particularly urgent. This study
Wang, Lidong, Wu, Xin, Wang, XinLu, Dong, Meng, Zhang, Hao, Zhao, Pengfei   +5 more
openaire   +2 more sources

Inhibition of prostatic cancer growth by ginsenoside Rh2

Tumor Biology, 2014
Ginsenoside Rh2 (GRh2) has been reported to have therapeutic effects on some types of cancer, but its effect on prostatic cancer has not been extensively evaluated. Here, we show that GRh2 can substantially inhibit the growth of prostatic cancer in vivo and in vitro.
Qingchuan, Zhang, Bin, Hong, Songhua, Wu, Tianli, Niu   +3 more
openaire   +2 more sources

Tandem Duplication‐Driven Neofunctionalization of UDP‐Glycosyltransferases Shapes the Diversification of Triterpenoid Saponins in the Cucurbitaceae

Advanced Science, EarlyView.
We present a chromosome‐level genome assembly of Siraitia grosvenorii and, through comparative genomics, uncover a conserved UGT73 tandem array driving triterpenoid saponin diversification in Cucurbitaceae. Crystalized SgUGT73AM30 further reveals the regioselectivity mechanism underlying its catalytic activity.
Guangyi Wang, Mengmeng Li, Xuehui Dai, Yanchen Zhang, Yuhan Wu, Zhaotao Yan, Chenfei Tian, Hongkai Fan, Haili Liu, Xiaowei Zhang, Yiming Yang, Jiayu Lu, Yuwei Sun, Yong Wang   +13 more
wiley   +1 more source

Ginsenoside Rh2 Inhibits NLRP3 Inflammasome Activation and Improves Exosomes to Alleviate Hypoxia-Induced Myocardial Injury

Frontiers in Immunology, 2022
The inflammatory microenvironment after acute myocardial infarction (MI) is a key limiting factor in the clinical application of stem cell transplantation and paracrine exosome therapy.
Zhongwen Qi, Zhongwen Qi, Zhongwen Qi, Zhipeng Yan, Zhipeng Yan, Zhipeng Yan, Yueyao Wang, Yueyao Wang, Yueyao Wang, Nan Ji, Xiaoya Yang, Ao Zhang, Meng Li, Fengqin Xu, Junping Zhang, Junping Zhang   +15 more
doaj   +1 more source

Ginsenoside Rh2 Suppresses Neovascularization in Xenograft Psoriasis Model [PDF]

Cellular Physiology and Biochemistry, 2015
Background/Aims: Psoriasis is a common inflammatory skin disease of undetermined etiology and poor prognosis. The current therapies have focused on direct inhibition of local inflammation, e.g. through hormone treatments. However, neovascularization plays a critical role in the development of psoriasis but so far no therapies have been developed to ...
Jing Zhou, Yunlu Gao, Xuemei Yi, Yangfeng Ding   +3 more
openaire   +3 more sources

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Production of the Rare Ginsenoside Rh2-MIX (20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3) by Enzymatic Conversion Combined with Acid Treatment and Evaluation of Its Anti-Cancer Activity

Journal of Microbiology and Biotechnology, 2017
The ginsenoside Rh2 has strong anti-cancer, anti-inflammatory, and anti-diabetic effects. However, the application of ginsenoside Rh2 is restricted because of the small amounts found in Korean white and red ginsengs. To enhance the production of ginsenoside Rh2-MIX (comprising 20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3 as a 10-g unit) with high specificity ...
Bong-Kyu, Song, Kyeng Min, Kim, Kang-Duk, Choi, Wan-Taek, Im   +3 more
openaire   +2 more sources