Results 31 to 40 of about 51,391 (176)

COMPARATIVE STUDY OF ECHINOCHROME A, OXYGENATED CAROTENOIDS, GINSENOSIDE Rh2, LUTEOLIN DISULFATE AND METFORMIN AS A MEAN TO POTENTIATE ANTITUMOR EFFECT OF DOXORUBICIN

Медицинская иммунология, 2018
This work concerned a comparative study of potentiating effects produced by some drugs of natural origin, as well as metformin, upon antitumor activity of doxorubicin. An increased therapeutic efficacy of doxorubicin used in combination with echinochrome
A. V. Tsybulsky, A. M. Popov, A. A. Klimovich, A. A. Artyukov, E. Ya. Kostetsky, M. D. Veselova   +5 more
doaj   +1 more source

Ginsenoside Rh2 represses autophagy to promote cervical cancer cell apoptosis during starvation

Chinese Medicine, 2020
Background Cancer cells through autophagy-mediated recycling to meet the metabolic demands of growth and proliferation. The steroidal saponin 20(S)-ginsenoside Rh2 effectively inhibits the growth and survival of a variety of tumor cell lines and animal ...
Jiawen Wang, Shuai Bian, Siming Wang, Song Yang, Wanying Zhang, Daqing Zhao, Meichen Liu, Xueyuan Bai   +7 more
doaj   +1 more source

Comparative analysis of the expression level of recombinant ginsenoside-transforming β-glucosidase in GRAS hosts and mass production of the ginsenoside Rh2-Mix. [PDF]

PLoS ONE, 2017
The ginsenoside Rh2, a pharmaceutically active component of ginseng, is known to have anticancer and antitumor effects. However, white ginseng and red ginseng have extremely low concentrations of Rh2 or Rh2-Mix [20(S)-Rh2, 20(R)-Rh2, Rk2, and Rh3].
Muhammad Zubair Siddiqi, Chang-Hao Cui, Seul-Ki Park, Nam Soo Han, Sun-Chang Kim, Wan-Taek Im   +5 more
doaj   +1 more source

Induction of apoptosis in prostate cancer by ginsenoside Rh2

Oncotarget, 2018
The therapeutic action of ginsenoside Rh2 on several cancer models has been reported. This study aimed to evaluate its apoptotic effect on prostate cancer and the underlying mechanism. Cultured DU145 cells were treated with Rh2 (5 × 10-5 to 1 × 10-4 M), peroxisome proliferator-activated receptor-delta (PPAR-delta) antagonist GSK0660 (1 × 10-6 to 5 × 10-
Tong-Lin Wu, Tony, Tong, Yat-Ching, Chen, I-Hung, Niu, Ho-Shan, Li, Yingxiao, Cheng, Juei-Tang   +5 more
openaire   +3 more sources

Synergistic effect of combined protopanaxatiol and ginsenoside Rh2 on antiproliferative activity in MDA-MB-231 human breast cancer cells in vitro

Food and Agricultural Immunology, 2018
Breast cancer is the most common cancer in women worldwide. The antiproliferative activities of protopanaxatiol (PPT) and ginsenoside Rh2 was measured by evaluating the inhibition of MDA-MB-231 human breast cancer cell proliferation.
Guixing Ren, Caie Wu, Cong Teng, Yang Yao   +3 more
doaj   +1 more source

Network Pharmacology-Based Study on the Mechanism of Ginsenoside Rh2 in Glioma Treatment

Natural Product Communications, 2022
Glioma, originated from the neuroectoderm, is one of the prevalent tumors. It is reported that ginsenoside Rh2, a compound extracted from Panax ginseng, shows pharmacological activity in inhibiting the proliferation and metastasis of glioma cells ...
Xue Wu, Xiujiao Qin, Han Dong
doaj   +1 more source

Targeting CHEK1: Ginsenosides-Rh2 and Cu2O@G-Rh2 nanoparticles in thyroid cancer

Cell Biology and Toxicology
Thyroid cancer (THCA) is an increasingly common malignant tumor of the endocrine system, with its incidence rising steadily in recent years. For patients who experience recurrence or metastasis, treatment options are relatively limited, and the prognosis is poor. Therefore, exploring new therapeutic strategies has become particularly urgent. This study
Wang, Lidong, Wu, Xin, Wang, XinLu, Dong, Meng, Zhang, Hao, Zhao, Pengfei   +5 more
openaire   +2 more sources

A stereo-selective growth inhibition profile of ginsenoside Rh2 on human colon cancer cells

CyTA - Journal of Food, 2019
We compared the stereo-selective growth inhibition effects of purified enantiomeric pairs of ginsenoside Rh2 (20(S)-ginsenoside Rh2 and 20(R)-ginsenoside Rh2) on human colon cancer cells in vitro with non-invasive real-time cellular analysis. When 50 μM,
Yunju Jeong, Seockmo Ku, Hyun Ju You, Geun Eog Ji   +3 more
doaj   +1 more source

Ginsenoside Rh2 Inhibits NLRP3 Inflammasome Activation and Improves Exosomes to Alleviate Hypoxia-Induced Myocardial Injury

Frontiers in Immunology, 2022
The inflammatory microenvironment after acute myocardial infarction (MI) is a key limiting factor in the clinical application of stem cell transplantation and paracrine exosome therapy.
Zhongwen Qi, Zhongwen Qi, Zhongwen Qi, Zhipeng Yan, Zhipeng Yan, Zhipeng Yan, Yueyao Wang, Yueyao Wang, Yueyao Wang, Nan Ji, Xiaoya Yang, Ao Zhang, Meng Li, Fengqin Xu, Junping Zhang, Junping Zhang   +15 more
doaj   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source