Effects of gintonin-enriched fraction on hippocampal gene expressions [PDF]
Integrative Medicine Research, 2021 Background: Recently, gintonin and gintonin-enriched fraction (GEF) have been isolated from ginseng, a herbal medicine. Gintonin induces [Ca2+]i transition in cultured hippocampal neurons and stimulates acetylcholine release through LPA receptor ...
Rami Lee +8 more
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Effect of the Gintonin-Enriched Fraction on Glucagon-Like-Protein-1 Release [PDF]
Molecules, 2021 Ginseng-derived gintonin reportedly contains functional lysophosphatidic acids (LPAs) as LPA receptor ligands. The effect of the gintonin-enriched fraction (GEF) on in vitro and in vivo glucagon-like protein-1 (GLP-1) secretion, which is known to ...
Rami Lee +7 more
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Effects of Gintonin-enriched fraction on the gene expression of six lysophosphatidic receptor subtypes [PDF]
Journal of Ginseng Research, 2021 Background: Gintonin, isolated from ginseng, acts as a ginseng-derived lysophosphatidic acid (LPA) receptor ligand and elicits the [Ca2+]i transient through six LPA receptor subtypes (LPARSs). However, the long-term effects of gintonin-enriched fraction (
Rami Lee +9 more
doaj +7 more sources
Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study [PDF]
Journal of Ginseng Research, 2020 Background: Ginseng has been widely used as a health-promoting tonic. Gintonin present in ginseng acts as a lysophosphatidic acid (LPA) receptor ligand that activates six LPA receptor subtypes. The LPA6 subtype plays a key role in normal hair growth, and
Na-Eun Lee +11 more
doaj +9 more sources
Gintonin-Enriched Fraction Suppresses Heat Stress-Induced Inflammation through LPA Receptor [PDF]
Molecules, 2020 Heat stress can be caused by various environmental factors. When exposed to heat stress, oxidative stress and inflammatory reaction occur due to an increase of reactive oxygen species (ROS) in the body.
Sungwoo Chei +7 more
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Bioactive lipids in gintonin-enriched fraction from ginseng [PDF]
Journal of Ginseng Research, 2019 Background: Ginseng is a traditional herbal medicine for human health. Ginseng contains a bioactive ligand named gintonin. The active ingredient of gintonin is lysophosphatidic acid C18:2 (LPA C18:2).
Hee-Jung Cho +7 more
doaj +6 more sources
Safety and efficacy of dietary supplement (gintonin-enriched fraction from ginseng) in subjective memory impairment: A randomized placebo-controlled trial [PDF]
Integrative Medicine Research, 2022 Background: Gintonin inhibits β-amyloid production, increases acetylcholine level in the brain, and promotes neurogenesis. We evaluated the efficacy of gintonin-enriched fraction (GEF) in improving the cognitive performance in subjective memory ...
Woo-Jin Lee +7 more
doaj +7 more sources
Gintonin-enriched fraction improves sarcopenia by maintaining immune homeostasis in 20- to 24-month-old C57BL/6J mice [PDF]
Journal of Ginseng Research, 2021 Background: Gintonin-enriched fraction (GEF) is a new non-saponin component glycolipoprotein isolated from ginseng root. This study examined the effect of GEF on age-related sarcopenia in old C57BL/6J mice.
Hyun-Ji Oh +3 more
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Gintonin-enriched fraction protects against sarcopenic obesity by promoting energy expenditure and attenuating skeletal muscle atrophy in high-fat diet-fed mice [PDF]
Journal of Ginseng Research, 2022 Background: Gintonin-enriched fraction (GEF), a non-saponin fraction of ginseng, is a novel glycolipoprotein rich in hydrophobic amino acids. GEF has recently been shown to regulate lipid metabolism and browning in adipocytes; however, the mechanisms ...
Heegu Jin +3 more
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Cognitive function improvement effects of gintonin-enriched fraction in subjective memory impairment: An assessor- and participant-blinded placebo-controlled study [PDF]
Journal of Ginseng Research, 2023 Background: Gintonin is a new material of ginseng that acts through the ginseng-derived lysophosphatidic acid (LPA) receptor ligand. The gintonin-enriched fraction (GEF) inhibits amyloid plaque accumulation in the cortex and hippocampus, improves ...
Rami Lee +4 more
doaj +5 more sources