Results 71 to 80 of about 631 (158)

Neural Crest-Like Stem Cell Transcriptome Analysis Identifies LPAR1 in Melanoma Progression and Therapy Resistance [PDF]

, 2021
Metastatic melanoma is challenging to clinically address. Although standard-of-care targeted therapy has high response rates in patients with BRAF-mutant melanoma, therapy relapse occurs in most cases. Intrinsically resistant melanoma cells drive therapy
Alicea, Gretchen M., Amaravadi, Ravi K., Aza-Blanc, Pedro, Beqiri, Marilda, Boland, Genevieve M., Brafford, Patricia, Cheng, Chaoran, Connelly, Thomas, Delvadia, Bela, Delvadia, Maya, Flaherty, Keith T., Frederick, Dennie T., Fukunaga-Kalabis, Mizuho, Gutierrez, Alexis, Herlyn, Meenhard, Hristova, Denitsa M., Huang, Ye, Karakousis, Giorgos C., Kossenkov, Andrew V., Krepler, Clemens, Kwong, Lawrence N., Li, Ling, Liu, Jianglan, Liu, Qin, Lu, Yiling, Mills, Gordon B., Mitchell, Tara C., Morias, Alice S., Rebecca, Vito W., Ronai, Ze'ev A., Salvino, Joseph M., Samarkina, Anastasia, Schuchter, Lynn M., Somasundaram, Rajasekharan, Speicher, David W., Sproesser, Katrin, Tong, Cynthia, Vultur, Adina, Wang, Joshua X., Wei, Zhi, Wu, Lawrence W., Xiao, Min, Xu, Wei, Xu, Xiaowei, Yang, Chih Cheng, Zayasbazan, Delaine, Zhang, Gao, Zhang, Jie   +47 more
core   +1 more source

Mechanisms of Panax ginseng action as an antidepressant

Cell Proliferation, Volume 52, Issue 6, November 2019., 2019
Abstract Objectives Panax ginseng, a well‐known traditional Chinese medicine with multiple pharmacological activities, plays a crucial role in modulating mood disorders. Several recent studies have identified an underlying role of Panax ginseng in the prevention and treatment of depression. However, the cellular and molecular mechanisms remain unclear.
Yang Jin, Ranji Cui, Lihong Zhao, Jie Fan, Bingjin Li   +4 more
wiley   +1 more source

Anti‐Inflammatory Activity of Rg3‐Enriched Korean Red Ginseng Extract in Murine Model of Sepsis

Evidence-Based Complementary and Alternative Medicine, Volume 2018, Issue 1, 2018., 2018
Ginseng has therapeutic effects on various bodily disorders ranging from minor inflammation to major cardiovascular diseases. In our study, we explored the anti‐inflammatory effects of Rg3‐enriched red ginseng extract (Rg3‐RGE), a ginsenoside belonging to the panaxadiol group.
Evelyn Saba, Dahye Jeong, Muhammad Irfan, Yuan Yee Lee, Sang-Joon Park, Chae-Kyu Park, Man Hee Rhee, José L. Rios   +7 more
wiley   +1 more source

Botanicals as Modulators of Neuroplasticity: Focus on BDNF

Neural Plasticity, Volume 2017, Issue 1, 2017., 2017
The involvement of brain‐derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored.
Enrico Sangiovanni, Paola Brivio, Mario Dell’Agli, Francesca Calabrese, Stuart C. Mangel   +4 more
wiley   +1 more source

Dual Role of Lysophosphatidic Acid Receptor 2 (LPA2) in Amyotrophic Lateral Sclerosis [PDF]

, 2021
Lysophosphatidic acid (LPA) is a pleiotropic extracellular lipid mediator with many physiological functions that signal through six known G protein-coupled receptors (LPA1-6).
Andrés Benito, Pol, Chun, Jerold, Ferrer, Isidro (Ferrer Abizanda), López Vales, Rubèn, Martínez Muriana, Anna, Puigdomenech Poch, Maria   +5 more
core   +2 more sources

The Role of Lysophosphatidic Acid in Neuropsychiatric and Neurodegenerative Disorders [PDF]

Individuals suffering from diverse neuropsychiatric and neurodegenerative disorders often have comparable symptoms, which may underline the implication of shared hereditary influences and the same biological processes.
Camoglio, Chiara, Dedoni, Simona, Fadda, Paola, Fratta, Walter, Scherma, Maria, Siddi, Carlotta   +5 more
core   +1 more source

Ginseng intake and Alzheimer disease-specific cognition in older adults according to apolipoprotein ε4 allele status [PDF]

, 2023
BackgroundThe probable association among ginseng intake, Alzheimer’s disease (AD)-specific cognition, and apolipoprotein ε4 (APOE4) remains poorly investigated.
Boung Chul Lee, Boung Chul Lee, Dahyun Yi, Guk-Hee Suh, Guk-Hee Suh, Hyun Soo Kim, Ihn-Geun Choi, Ihn-Geun Choi, Jaeuk Hwang, Jee Wook Kim, Jee Wook Kim, Jin Hyeong Jhoo, Young Min Choe, Young Min Choe   +13 more
core   +1 more source

Proteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer’s Disease

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
In recent years, there has been an increasing worldwide interest in traditional Chinese medicine (TCM). This increasing demand for TCM needs to be accompanied by a deeper understanding of the mechanisms of action of TCM‐based therapy. However, TCM is often described as a concept of Chinese philosophy, which is incomprehensible for Western medical ...
Yanuar Alan Sulistio, Klaus Heese, Xuan Liu   +2 more
wiley   +1 more source

Effects of gintonin on the proliferation, migration, and tube formation of human umbilical-vein endothelial cells: involvement of lysophosphatidic-acid receptors and vascular-endothelial-growth-factor signaling

Journal of Ginseng Research, 2016
Background: Ginseng extracts are known to have angiogenic effects. However, to date, only limited information is available on the molecular mechanism underlying the angiogenic effects and the main components of ginseng that exert these effects.
Sung-Hee Hwang, Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Kyung Jong Won, Hwan Myung Lee, Hyewon Rhim, Hyoung-Chun Kim, Seung-Yeol Nah   +8 more
doaj   +1 more source

A Novel Korean Red Ginseng Compound Gintonin Inhibited Inflammation by MAPK and NF‐κB Pathways and Recovered the Levels of mir‐34a and mir‐93 in RAW 264.7 Cells

Evidence-Based Complementary and Alternative Medicine, Volume 2015, Issue 1, 2015., 2015
The beneficial health promoting effects of ginseng from vitalizing the body to enhancing long life have been well explored very rapidly in the past few years. Up till now many ginsenosides have been discovered for their marvelous therapeutic effects. However during past three years, a novel ginseng compound has been discovered, called gintonin, that ...
Evelyn Saba, Bo Ra Jeon, Da-Hye Jeong, Kija Lee, Youn-Kyoung Goo, Dongmi Kwak, Suk Kim, Seong-Soo Roh, Sung Dae Kim, Seung-Yeol Nah, Man Hee Rhee, Raffaele Capasso   +11 more
wiley   +1 more source