Botanicals as Modulators of Neuroplasticity: Focus on BDNF
The involvement of brain‐derived neurotrophic factor (BDNF) in different central nervous system (CNS) diseases suggests that this neurotrophin may represent an interesting and reliable therapeutic target. Accordingly, the search for new compounds, also from natural sources, able to modulate BDNF has been increasingly explored.
Enrico Sangiovanni +4 more
wiley +1 more source
Ginseng intake and Alzheimer disease-specific cognition in older adults according to apolipoprotein ε4 allele status [PDF]
BackgroundThe probable association among ginseng intake, Alzheimer’s disease (AD)-specific cognition, and apolipoprotein ε4 (APOE4) remains poorly investigated.
Boung Chul Lee +13 more
core +1 more source
Proteomics in Traditional Chinese Medicine with an Emphasis on Alzheimer’s Disease
In recent years, there has been an increasing worldwide interest in traditional Chinese medicine (TCM). This increasing demand for TCM needs to be accompanied by a deeper understanding of the mechanisms of action of TCM‐based therapy. However, TCM is often described as a concept of Chinese philosophy, which is incomprehensible for Western medical ...
Yanuar Alan Sulistio +2 more
wiley +1 more source
The Role of Lysophosphatidic Acid in Neuropsychiatric and Neurodegenerative Disorders [PDF]
Individuals suffering from diverse neuropsychiatric and neurodegenerative disorders often have comparable symptoms, which may underline the implication of shared hereditary influences and the same biological processes.
Camoglio, Chiara +5 more
core +1 more source
Dual Role of Lysophosphatidic Acid Receptor 2 (LPA2) in Amyotrophic Lateral Sclerosis [PDF]
Lysophosphatidic acid (LPA) is a pleiotropic extracellular lipid mediator with many physiological functions that signal through six known G protein-coupled receptors (LPA1-6).
Andrés Benito, Pol +5 more
core +2 more sources
The beneficial health promoting effects of ginseng from vitalizing the body to enhancing long life have been well explored very rapidly in the past few years. Up till now many ginsenosides have been discovered for their marvelous therapeutic effects. However during past three years, a novel ginseng compound has been discovered, called gintonin, that ...
Evelyn Saba +11 more
wiley +1 more source
Role of Lysophosphatidic Acid in Neurological Diseases: From Pathophysiology to Therapeutic Implications [PDF]
Lysophosphatidic acid (LPA), a bioactive lipid molecule, has been identified as a critical regulator of several cellular processes in the central nervous system, with significant impacts on neuronal function, synaptic plasticity, and neuroinflammatory ...
Avdoshina, Valeria +3 more
core +1 more source
Background: Gintonin-enriched fraction (GEF) is a new non-saponin component glycolipoprotein isolated from ginseng root. This study examined the effect of GEF on age-related sarcopenia in old C57BL/6J mice.
Hyun-Ji Oh +3 more
doaj +1 more source
The Relationship Between Vitamin D Status and Fall Risk in Elderly with Chronic Kidney Disease on Regular Hemodialysis [PDF]
Introduction. Fall is one of the main causes of hospitalization in the elderly, which is caused by several factors including gait disturbances, balance disorders, visual disturbances, chronic kidney disease (CKD), vitamin D deficiency, and so on ...
Dina Aprillia Ariestine +2 more
core +2 more sources
Effects of a gintonin-enriched fraction on hair growth: an in vitro and in vivo study
Background: Ginseng has been widely used as a health-promoting tonic. Gintonin present in ginseng acts as a lysophosphatidic acid (LPA) receptor ligand that activates six LPA receptor subtypes. The LPA6 subtype plays a key role in normal hair growth, and
Na-Eun Lee +11 more
doaj +1 more source

