Results 141 to 150 of about 61,152 (267)

Factors Associated With the Emergence and Spread of Visceral Leishmaniasis in the State of São Paulo, Brazil

Zoonoses and Public Health, EarlyView.
ABSTRACT Introduction Visceral leishmaniasis (VL), once considered a rural disease in Brazil, has progressively urbanised, particularly in the state of São Paulo (SSP), where the first urban cases emerged after the detection of the vector Lutzomyia longipalpis in 1997.
Vera Lucia Fonseca de Camargo‐Neves, Guilherme Loureiro Werneck   +1 more
wiley   +1 more source

Resistance exercise breaks during prolonged sitting augment the blood flow response to a subsequent oral glucose load in sedentary adults

Experimental Physiology, EarlyView.
Abstract Sitting‐induced impairments in postprandial blood flow are an important link between sedentary behaviour and cardiometabolic disease risk. The objective of this work was to examine the effects of resistance exercise breaks (REB) performed every 30 min during an otherwise sedentary 3‐h period on the vasodilatory response to a subsequent oral ...
Emily M. Rogers, Nile F. Banks, Emma R. Trachta, Morgan S. Wolf, Alexander C. Berry, Anna E. Stanhewicz, Lucas J. Carr, Bethany Barone Gibbs, Nathaniel D. M. Jenkins   +8 more
wiley   +1 more source

Lifestyle modification in atrial fibrillation: Mechanisms, phenotypes and ablation outcomes

Experimental Physiology, EarlyView.
Abstract Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia and is associated with significant morbidity, mortality and healthcare utilization. Catheter ablation is increasingly used as a rhythm‐control intervention for patients with symptomatic paroxysmal and persistent AF, yet recurrence rates remain suboptimal.
Konstantinos Grigoriou, Paschalis Karakasis, Panagiotis Theofilis, Konstantinos Pamporis, Panayotis K. Vlachakis, Anastasios Apostolos, Nikolaos Ktenopoulos, Barbara Fyntanidou, Efstratios Karagiannidis, Dimitrios Patoulias, Antonios P Antoniadis, Nikolaos Fragakis   +11 more
wiley   +1 more source

Calciprotein particle‐induced calcium overload triggers mitochondrial dysfunction in endothelial cells

The Journal of Physiology, EarlyView.
Abstract figure legend Calciprotein particles (CPPs) are small calcium‐ and phosphate‐containing nanoaggregates associated with the development of vascular disease (CVD) in chronic kidney disease (CKD). Previously, we have shown that CPPs induce endothelial cell (EC) dysfunction, possibly contributing to CVD in CKD, but the underlying molecular ...
Lian Feenstra, Laurent Chatre, Benoit Bernay, Julien Pontin, Mirjam F. Mastik, Azuwerus van Buiten, Dalibor Nakládal, Bastiaan S. Star, Jan‐Luuk Hillebrands, Guido Krenning   +9 more
wiley   +1 more source

Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes

The Journal of Physiology, EarlyView.
Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve, Margaux Aize, Maximin Détrait, Laura Brard, Adrien Leboyer, Pierre‐Antoine Dupont, Alexandre Lebrun, Vladimir Saplacan, Christophe Simard, Fabien Brette, Frank Lezoualc'h, Laurent Sallé   +11 more
wiley   +1 more source

c‐Jun N‐terminal kinase 3 as a permissive regulator of β‐cell incretin responsiveness

Journal of Diabetes Investigation, EarlyView.
Yuji Yamazaki
wiley   +1 more source

Sex‐specific metabolic responses to glucagon receptor agonism and modulation of the FGF21‐glucagon axis in female mice

The Journal of Physiology, EarlyView.
Abstract figure legend Therapies targeting the glucagon receptor are being explored for obesity treatment, yet most preclinical studies remain male biased. In this study, Merrild and Johansen et al. show that in diet‐induced obese wild‐type mice a long‐acting glucagon analogue (LA‐Gcg) elicits sexually dimorphic effects on weight loss, food intake ...
Christoffer Merrild, Valdemar Brimnes Ingemann Johansen, Christoffer Clemmensen, Pablo Ranea‐Robles   +3 more
wiley   +1 more source

Revitalizing GIP: Therapeutic Potential in Metabolic and Neurodegenerative Disorders. [PDF]

Diabetes Metab Syndr Obes
Qiao Y, Zhou F, Mao T, Gao L.
europepmc   +1 more source

Not All GLP‐1 Receptor Agonists Are Alike: Real‐World Evidence of Differential Endocrine and Dermatologic Safety

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 4, May 2026.
ABSTRACT Aims Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) are widely used for metabolic disorders, but emerging safety concerns include alopecia and reproductive or endocrine‐related adverse events (AEs). This study investigated the association between specific GLP‐1 RAs and these endocrine‐related AEs using a large‐scale pharmacovigilance ...
Nai Lee, Yun Kim
wiley   +1 more source

Real-world 6-month persistence, adherence, and effectiveness of GLP-1 medications for overweight and obesity in a Medicaid population. [PDF]

J Manag Care Spec Pharm
Meyer KB, McVeigh M, Chiara AN, Boss KC, Pomfret TC, Semmel K, Bacon R, Nicolas D, Clements K, Alper CJ, Lenz K.   +10 more
europepmc   +1 more source