Results 121 to 130 of about 74,465 (332)

Twenty‐Four Month Outcomes From a Real‐World Telehealth Obesity Treatment Clinic Using Obesity Medications

Obesity, EarlyView.
ABSTRACT Objective Antiobesity medications (AOMs) are indicated for long‐term use; however, evidence of their real‐world long‐term efficacy is limited. This study describes clinical outcomes from 18‐ and 24‐month use of AOMs in a telemedicine weight management clinic.
Kathleen R. Ruddiman, Young‐Rock Hong, Jamy Ard, Rebecca Jones, Adam Medcalf, Gary D. Foster, Jamil Alkhaddo, Michelle Cardel   +7 more
wiley   +1 more source

Beyond GLP‐1: The Cardiometabolic Potential of Dual GLP‐1/GIP Receptor Agonists

iNew Medicine, EarlyView.
Chao Xue
wiley   +1 more source

Weight Loss With GLP‐1 Agonists in Nondiabetic Adults: Systematic Review and Network Meta‐Analysis

Obesity, EarlyView.
ABSTRACT Objective Two glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) (semaglutide and liraglutide) and one dual agonist (tirzepatide) are FDA‐approved for weight loss in adults with obesity without type 2 diabetes mellitus. This systematic review and network meta‐analysis aims to compare the efficacy of these agents against each other.
Michael Lim, Pooja Gokhale, Akwasi Akosah, Lorenzo Villa‐Zapata   +3 more
wiley   +1 more source

From HBV to MASLD Cirrhosis: Mechanistic Insights and Therapeutic Strategies

Portal Hypertension &Cirrhosis, EarlyView.
This review examines the epidemiological shift from hepatitis B virus (HBV) to metabolic dysfunction‐associated steatotic liver disease (MASLD) as the leading cause of cirrhosis globally. It highlights the distinct pathogenic mechanisms between HBV and MASLD cirrhosis and discusses evolving diagnostic tools and therapeutic strategies tailored to the ...
Hanqi Yu, Hongfan Ding, Yang Huang, Haoze Cao, Yuan Ding, Weilin Wang   +5 more
wiley   +1 more source

Impact of the Covid-19 pandemic and lockdown on the mental health of people exposed to the terrorist attacks of 13 November 2015

BMC Psychiatry
Background In response to the widespread transmission of coronavirus diseases worldwide, France implemented a strict lockdown from March 17 to May 11, 2020. Objectives This study aimed to evaluate the mental health of individuals who have previously been
Amine Chakli, Grégory Lecouvey, Patrice Clochon, Florence Fraisse, Julien Chavant, Denis Peschanski, Pierre Gagnepain, Vincent de La Sayette, Francis Eustache, Jacques Dayan   +9 more
doaj   +1 more source

Glucose-dependent insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes: An association analysis of polymorphisms and bone in young and elderly women

Bone Reports, 2016
Introduction: The gastro-intestinal hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion, with bone anabolic effects through GIP receptor (GIPR) in animal models.
Gaurav Garg, Fiona E. McGuigan, Jitender Kumar, Holger Luthman, Valeriya Lyssenko, Kristina Akesson   +5 more
doaj   +1 more source

Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition

Journal of Clinical Investigation, 2019
Nutrient excess, a major driver of obesity, diminishes hypothalamic responses to exogenously administered leptin, a critical hormone of energy balance.
Kentaro Kaneko, Yukiko Fu, Hsiao-Yun Lin, E. Cordonier, Q. Mo, Yong Gao, Ting Yao, J. Naylor, Victor G. Howard, Kenji Saito, Pingwen Xu, Siyu S Chen, Miao-Hsueh Chen, Yong Xu, Kevin W. Williams, P. Ravn, M. Fukuda   +16 more
semanticscholar   +1 more source

Redefining Optimal Coverage Path Planning for FLS‐Equipped AUVs With Deep Reinforcement Learning

Journal of Field Robotics, EarlyView.
ABSTRACT Autonomous Underwater Vehicles (AUVs) have emerged as indispensable tools for a variety of subsea tasks, from habitat monitoring and seabed mapping to infrastructure inspection and mine countermeasures. A fundamental challenge in this field is Coverage Path Planning (CPP), the problem of ensuring complete and efficient area coverage.
Lorenzo Cecchi, Alberto Topini, Alessandro Bucci, Alessandro Ridolfi   +3 more
wiley   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene

Journal of Lipid Research, 2010
GIP (glucose-dependent insulinotropic polypeptide) is a gastrointestinal hormone that regulates pancreatic islet function. Additionally, emerging evidence suggests an important physiological role for GIP in the regulation of adipocyte metabolism.
Su-Jin Kim, Cuilan Nian, Christopher H.S. McIntosh   +2 more
doaj   +1 more source