Results 111 to 120 of about 74,465 (332)
64Cu-ATSM/64Cu-Cl2 and their relationship to hypoxia in glioblastoma: a preclinical study
EJNMMI Research, 2019 Background Diacetyl-bis(N4-methylthiosemicarbazone), labeled with 64Cu (64Cu-ATSM) has been suggested as a promising tracer for imaging hypoxia. However, various controversial studies highlighted potential pitfalls that may disable its use as a selective
Elodie A. Pérès +11 more
doaj +1 more source
Glucose-dependent insulinotropic polypeptide (GIP) directly affects collagen fibril diameter and collagen cross-linking in osteoblast cultures. [PDF]
, 2015 Glucose-dependent insulinotropic polypeptide (GIP) is absolutely crucial in order to obtain optimal bone strength and collagen quality. However, as the GIPR is expressed in several tissues other than bone, it is difficult to ascertain whether the ...
A. Mieczkowska +3 more
core +4 more sources
Neuropharmacology, 2018 Type 2 diabetes is a risk factor for several chronic neurodegenerative disorders such as Alzheimer's or Parkinson's disease. The link appears to be insulin de-sensitisation in the brain. Insulin is an important neuroprotective growth factor.
C. Hölscher
semanticscholar +1 more source
Reframing the role of glucagon‐like peptide 1 receptor agonists in cardiovascular medicine
ESC Heart Failure, Volume 12, Issue 2, Page 923-926, April 2025.
Riccardo M. Inciardi +3 more
wiley +1 more source
Obesity, EarlyView.ABSTRACT Objective This study aimed to evaluate whether reduced‐frequency dosing of GLP1 receptor agonists maintains weight loss, body composition, and metabolic syndrome improvements following successful initial treatment with standard weekly therapy. Methods This retrospective case series included 30 adults who achieved weight plateau while on weekly
Michelle Wong +3 more
wiley +1 more source
Incretin-based therapies for cardio-kidney-liver-metabolic disease: the role of the liver in the modern era of chronic disease management [PDF]
Clinical and Molecular HepatologySteatotic liver disease (SLD) is a leading cause of disease globally and demands new therapeutic approaches to mitigate underlying metabolic dysregulation. Incretin-based therapies are emerging as a viable prospect to fulfil this unmet niche.
Harendran Elangovan +7 more
doaj +1 more source
The coarse Baum-Connes conjecture for relatively hyperbolic groups
, 2011 We study a group which is hyperbolic relative to a finite family of infinite subgroups. We show that the group satisfies the coarse Baum-Connes conjecture if each subgroup belonging to the family satisfies the coarse Baum-Connes conjecture and admits a ...
Fukaya, Tomohiro, Oguni, Shin-ichi
core +1 more source
Retatrutide Shows Multiple Metabolic Benefits in Diet‐Induced Obese MASH Mouse and Hamster Models
Obesity, EarlyView.ABSTRACT Objective/Methods Our aim was to evaluate the efficacy of the triple glucagon, GIP, and GLP‐1 receptor agonist retatrutide in diet‐induced obese MASH mouse and hamster models, two preclinical models that we routinely use for assessing new therapies targeting obesity.
François Briand +6 more
wiley +1 more source
EJNMMI Research, 2019 Purpose Preclinical imaging of endothelial activation and mineralization using both positron emission tomography (PET) and magnetic resonance (MR) remains scarce.
Guillaume Rucher +10 more
doaj +1 more source
, 2010 This paper studies optimal bandwidth and power allocation in a cognitive radio network where multiple secondary users (SUs) share the licensed spectrum of a primary user (PU) under fading channels using the frequency division multiple access scheme.
Gong, Xiaowen +2 more
core +1 more source