Results 101 to 110 of about 30,994 (308)

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

open access: yesObesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter   +14 more
wiley   +1 more source

Pathogenesis of type 2 diabetes in Japan and East Asian populations: Basic and clinical explorations

open access: yesProceedings of the Japan Academy. Series B, Physical and Biological Sciences
It is now accepted that the pathogenesis of type 2 diabetes in East Asians including Japanese differs distinctly from that in Caucasians. Many non-obese individuals in Japan develop type 2 diabetes and present clinically with insufficient insulin ...
Yutaka SEINO, Yuji YAMAZAKI
doaj   +1 more source

Glucagon‐Like Peptide‐1 Receptor Agonists for Obstructive Sleep Apnea With and Without Continuous Positive Airway Pressure

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate glucagon‐like peptide 1 receptor agonists for obstructive sleep apnea compared with controls. Data Sources CINAHL, Cochrane Library, PubMed, and Scopus. Review Methods A PRISMA‐compliant search was conducted from database inception through October 2025.
Cali Loblundo   +3 more
wiley   +1 more source

Physiology and clinical applications of GIP

open access: yesEndocrine Journal
Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells, primarily located in the upper small intestine, in response to food intake and plays a significant role in the postprandial regulation of nutrient metabolism ...
Shunsuke Yamane   +2 more
doaj   +1 more source

Molecular imaging of endothelial activation and mineralization in a mouse model of accelerated atherosclerosis

open access: yesEJNMMI Research, 2019
Purpose Preclinical imaging of endothelial activation and mineralization using both positron emission tomography (PET) and magnetic resonance (MR) remains scarce.
Guillaume Rucher   +10 more
doaj   +1 more source

The Return of the Allis Shad (Alosa alosa) to the Lower Navigable Reaches of the Seine: Locks Play a Role

open access: yesRiver Research and Applications, EarlyView.
ABSTRACT In France, it is estimated that shads (Alosa spp.) have lost 69% of their historical range, mainly due to disrupted river connectivity. After an absence of one century, signs of their return in the Seine River have been recorded over the past two decades: adult and juvenile specimens have been caught by anglers or recorded at video‐counting ...
Céline Le Pichon   +5 more
wiley   +1 more source

City Diplomacy as a Green Strategy? International Sister City Partnerships and Urban Decarbonization

open access: yesSustainable Development, EarlyView.
ABSTRACT The establishment of international sister city partnerships (ISCPs) has expanded since the postwar era, developing from cultural exchanges into strategic diplomatic channels for sustainable development. While their socioeconomic benefits are well‐documented, their potential as instruments for global environmental governance and urban ...
Fubin Luo   +4 more
wiley   +1 more source

Development of geriatric medicines: to GIP or not to GIP?

open access: yes, 2014
The elderly population represents a heterogeneous group of patients, which show co-morbidities and is often poly-medicated. Although geriatric patients form the main users of medicines, this group is underrepresented in clinical trials. Safe and efficacious use of drugs by this group is often not ensured.
Stalmans, Sofie   +2 more
openaire   +1 more source

Reframing the role of glucagon‐like peptide 1 receptor agonists in cardiovascular medicine

open access: yes
ESC Heart Failure, Volume 12, Issue 2, Page 923-926, April 2025.
Riccardo M. Inciardi   +3 more
wiley   +1 more source

Chronic Disease and Disability in the United States: Trends, Inequities, and Imperatives for Policy Reform

open access: yesThe Milbank Quarterly, EarlyView.
Policy Points Position Universal, High‐Quality Education as a Foundational Public Health Strategy. Long‐term health and life expectancy in the United States are shaped more by educational attainment than by any other single factor. Disparities in access to early childhood, K‐12, and higher education perpetuate cycles of chronic disease, economic ...
ALI H. MOKDAD   +2 more
wiley   +1 more source

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