Results 91 to 100 of about 36,022 (296)

Daily administration of the GIP-R antagonist (Pro3)GIP in streptozotocin-induced diabetes suggests that insulin-dependent mechanisms are critical to anti–obesity-diabetes actions of (Pro3)GIP

, 2008
AIM: \ud \ud Glucose-dependent insulinotropic polypeptide-receptor (GIP-R) antagonism using (Pro3)GIP improves glucose tolerance and ameliorates insulin resistance and abnormalities of islet structure and function in a commonly used model of obesity ...
McClean, P. L., McCluskey, Jane T., Flatt, P. R., Irwin, N., McCluskey, Jane T, Gault, V. A.   +5 more
core   +1 more source

The Return of the Allis Shad (Alosa alosa) to the Lower Navigable Reaches of the Seine: Locks Play a Role

River Research and Applications, EarlyView.
ABSTRACT In France, it is estimated that shads (Alosa spp.) have lost 69% of their historical range, mainly due to disrupted river connectivity. After an absence of one century, signs of their return in the Seine River have been recorded over the past two decades: adult and juvenile specimens have been caught by anglers or recorded at video‐counting ...
Céline Le Pichon, Frédérique Bau, Armand Michelot, Evelyne Tales, Sébastien Grall, Eric Rochard   +5 more
wiley   +1 more source

Stimulating intestinal GIP release reduces food intake and body weight in mice

Molecular Metabolism
Objective: Glucose dependent insulinotropic polypeptide (GIP) is well established as an incretin hormone, boosting glucose-dependent insulin secretion.
Jo E. Lewis, Danae Nuzzaci, Paula-Peace James-Okoro, Mireia Montaner, Elisabeth O'Flaherty, Tamana Darwish, Marito Hayashi, Stephen D. Liberles, David Hornigold, Jacqueline Naylor, David Baker, Fiona M. Gribble, Frank Reimann   +12 more
doaj   +1 more source

Development of geriatric medicines: to GIP or not to GIP?

, 2014
The elderly population represents a heterogeneous group of patients, which show co-morbidities and is often poly-medicated. Although geriatric patients form the main users of medicines, this group is underrepresented in clinical trials. Safe and efficacious use of drugs by this group is often not ensured.
Stalmans, Sofie, Bracke, Nathalie, De Spiegeleer, Bart   +2 more
openaire   +1 more source

N-glycosylation regulates GIP receptor number and GIP-potentiated insulin secretion in INS-1 cells.

, 2013
(A) Plot of specific binding versus concentration of 125I-GIP saturation carried out in INS-1 cells with or without 1 µg/ml tunicamycin. Data were fitted with a non-linear regression equation assuming a single binding site (GraphPad Prism). Control cells
Francis C. Lynn (271722), Christopher H. S. McIntosh (154145), Gina M. Whitaker (330353), Eric A. Accili (300748)   +3 more
core   +1 more source

City Diplomacy as a Green Strategy? International Sister City Partnerships and Urban Decarbonization

Sustainable Development, EarlyView.
ABSTRACT The establishment of international sister city partnerships (ISCPs) has expanded since the postwar era, developing from cultural exchanges into strategic diplomatic channels for sustainable development. While their socioeconomic benefits are well‐documented, their potential as instruments for global environmental governance and urban ...
Fubin Luo, Zimeng Kong, Xinyu Wang, Can Zhang, Yunzheng Zhang   +4 more
wiley   +1 more source

Question 2. Quelles sont les principales modalités de coupes de régénération, en forêts tempérées et boréales, et particulièrement en France métropolitaine ?

, 2023
International audienceLes modalités de renouvellement des peuplements, en particulier les coupes rases, font l’objet de vifs débats. Ce chapitre de l'expertise collective CRREF (Coupes Rases et renouvellement des Peuplement en contexte de changement ...
Landmann, Guy, Gosselin, Marion
core   +1 more source

Anti‐obesity medications and incident ocular outcomes: A systematic review and network meta‐analysis

VIEW, EarlyView.
In this systematic review and network meta‑analysis of 140 studies, anti‑obesity medications showed heterogeneous ocular safety profiles. Semaglutide was associated with higher NAION risk (observational data), whereas dual/multi‑agonists and glucagon‐like peptide‐1 receptor agonists demonstrated favourable glaucoma and overall ocular outcomes ...
Linge Jian, Keke Zhang, Wenwen He, Yan Ke, Yi Lu, Xiangjia Zhu   +5 more
wiley   +1 more source

Impact of the Covid-19 pandemic and lockdown on the mental health of people exposed to the terrorist attacks of 13 November 2015

BMC Psychiatry
Background In response to the widespread transmission of coronavirus diseases worldwide, France implemented a strict lockdown from March 17 to May 11, 2020. Objectives This study aimed to evaluate the mental health of individuals who have previously been
Amine Chakli, Grégory Lecouvey, Patrice Clochon, Florence Fraisse, Julien Chavant, Denis Peschanski, Pierre Gagnepain, Vincent de La Sayette, Francis Eustache, Jacques Dayan   +9 more
doaj   +1 more source

Glucose-dependent insulinotropic polypeptide (GIP) and GIP receptor (GIPR) genes: An association analysis of polymorphisms and bone in young and elderly women

Bone Reports, 2016
Introduction: The gastro-intestinal hormone glucose-dependent insulinotropic polypeptide (GIP) potentiates glucose-induced insulin secretion, with bone anabolic effects through GIP receptor (GIPR) in animal models.
Gaurav Garg, Fiona E. McGuigan, Jitender Kumar, Holger Luthman, Valeriya Lyssenko, Kristina Akesson   +5 more
doaj   +1 more source