Results 81 to 90 of about 27,755 (279)

GIP(Lys16PAL) and GIP(Lys37PAL): novel long-acting acylated analogues of glucose-dependent insulinotropic polypeptide with improved antidiabetic potential.

open access: yes, 2006
Glucose-dependent insulinotropic polypeptide (GIP) is a physiological insulin releasing peptide. We have developed two novel fatty acid derivatized GIP analogues, which bind to serum albumin and demonstrate enhanced duration of action in vivo. GIP(Lys(16)
Flatt, P.R.   +7 more
core   +1 more source

Redefining Optimal Coverage Path Planning for FLS‐Equipped AUVs With Deep Reinforcement Learning

open access: yesJournal of Field Robotics, EarlyView.
ABSTRACT Autonomous Underwater Vehicles (AUVs) have emerged as indispensable tools for a variety of subsea tasks, from habitat monitoring and seabed mapping to infrastructure inspection and mine countermeasures. A fundamental challenge in this field is Coverage Path Planning (CPP), the problem of ensuring complete and efficient area coverage.
Lorenzo Cecchi   +3 more
wiley   +1 more source

City Diplomacy as a Green Strategy? International Sister City Partnerships and Urban Decarbonization

open access: yesSustainable Development, EarlyView.
ABSTRACT The establishment of international sister city partnerships (ISCPs) has expanded since the postwar era, developing from cultural exchanges into strategic diplomatic channels for sustainable development. While their socioeconomic benefits are well‐documented, their potential as instruments for global environmental governance and urban ...
Fubin Luo   +4 more
wiley   +1 more source

Molecular imaging of endothelial activation and mineralization in a mouse model of accelerated atherosclerosis

open access: yesEJNMMI Research, 2019
Purpose Preclinical imaging of endothelial activation and mineralization using both positron emission tomography (PET) and magnetic resonance (MR) remains scarce.
Guillaume Rucher   +10 more
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

open access: yesBritish Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli   +7 more
wiley   +1 more source

Reframing the role of glucagon‐like peptide 1 receptor agonists in cardiovascular medicine

open access: yes
ESC Heart Failure, Volume 12, Issue 2, Page 923-926, April 2025.
Riccardo M. Inciardi   +3 more
wiley   +1 more source

Glucagon‐like peptide‐1 receptor agonists and muscle strength changes in older adults: Risks beyond muscle mass reductions

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Gastric inhibitory polypeptide (GIP)/Glucagon‐like peptide‐1 (GLP‐1) receptor agonists are increasingly prescribed for the management of obesity and type 2 diabetes, yet research pertinent to their effects on muscle health is limited. Considering the central role of muscle strength as a sarcopenia component, this article summarizes emerging ...
Konstantinos Prokopidis
wiley   +1 more source

N-glycosylation regulates GIP receptor number and GIP-potentiated insulin secretion in INS-1 cells.

open access: yes, 2013
(A) Plot of specific binding versus concentration of 125I-GIP saturation carried out in INS-1 cells with or without 1 µg/ml tunicamycin. Data were fitted with a non-linear regression equation assuming a single binding site (GraphPad Prism). Control cells
Francis C. Lynn (271722)   +3 more
core   +1 more source

Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley   +1 more source

Impact of the Covid-19 pandemic and lockdown on the mental health of people exposed to the terrorist attacks of 13 November 2015

open access: yesBMC Psychiatry
Background In response to the widespread transmission of coronavirus diseases worldwide, France implemented a strict lockdown from March 17 to May 11, 2020. Objectives This study aimed to evaluate the mental health of individuals who have previously been
Amine Chakli   +9 more
doaj   +1 more source

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