Results 151 to 160 of about 72,161 (311)

Endogenous GIP signaling is indispensable for DPP‐4 inhibitor‐mediated metabolic control in mice

Journal of Diabetes Investigation, EarlyView.
This study reveals that the metabolic benefits of DPP‐4 inhibitors, including improved glucose tolerance and reduced body weight, are completely abolished in GIP receptor‐deficient mice. These findings establish that endogenous GIP signaling, rather than GLP‐1, is the indispensable key player for the efficacy of this drug class.
Saki Kubota‐Okamoto, Sodai Kubota, Hiromi Tsuchida, Yanyan Liu, Seiya Banno, Toshinori Imaizumi, Taro Fujisawa, Yoshihiro Takahashi, Takehiro Kato, Yukio Horikawa, Katsumi Iizuka, Takaaki Murakami, Yuuka Fujiwara, Hitoshi Kuwata, Yuji Yamazaki, Yutaka Seino, Shin Tsunekawa, Daisuke Yabe   +17 more
wiley   +1 more source

Biology of incretins: GLP-1 and GIP.

Gastroenterology, 2007
L. Baggio, D. Drucker
semanticscholar   +1 more source

EEG Brain Rhythms During Resting‐State Wakefulness and Sleep in Elderly Expert Meditators

Journal of Sleep Research, EarlyView.
Compared to controls, elderly expert meditators exhibited (1) more preserved resting‐state brain activity, (2) less altered sleep architecture, and (3) EEG features indicative of heightened cognitive states during NREM sleep. Importantly, several of the metrics that differed between groups also showed consistent correlations with meditation expertise ...
Pierre Champetier, Anaïs Hamel, Claire André, Valentin Ourry, Tristan Lacroix, Stéphane Rehel, Léa Chauveau, Sacha Haudry, Françoise Bertran, Vincent de la Sayette, Denis Vivien, Gaël Chételat, Antoine Lutz, Géraldine Rauchs, Medit‐Ageing Research Group, Alexandre Bejanin, Anne Chocat, Fabienne Collette, Sophie Dautricourt, Robin De Flores, Marion Delarue, Harriet Demnitz‐King, Hélène Espérou, Séverine Fauvel, Francesca Felisatti, Eglantine Ferrand Devouge, Eric Frison, Julie Gonneaud, Oriane Hébert, Olga Klimecki, Elizabeth Kuhn, Brigitte Landeau, Valérie Lefranc, Natalie Marchant, Florence Mezenge, Cassandre Palix, Anne Quillard, Florence Requier, Daniel Roquet, Edelweiss Touron, Anne‐Laure Turpin, Patrik Vuilleumier, Tim Whitfield, Miranka Wirth   +43 more
wiley   +1 more source

A Systematic Review: Light Therapy for Individuals with Dementia and Implications for Practice [PDF]

, 2019
This systematic review seeks to answer the question: is light therapy an effective intervention for sundowning symptoms experienced by individuals who have ...
Goodman, OTS, E., Jacobs, MS, OTS, E., Kaiser, OTD, OTR/L, L., Mikus, OTS, C., Milione, OTS, A., Potvin, PhD, OTR/L, M.-C., Torres, OTS, A., Vu, OTS, V.   +7 more
core   +1 more source

GLP‐1 Receptor Agonists for the Prevention of New‐Onset Heart Failure: A Systematic Review and Meta‐Analysis of Placebo‐Controlled Randomized Clinical Trials

Obesity Reviews, EarlyView.
ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) improve outcomes in heart failure (HF) with preserved ejection fraction. Whether GLP‐1 RA prevent new‐onset HF in Type 2 diabetes or obesity requires further investigation. Methods We performed an updated meta‐analysis of randomized placebo‐controlled trials (RCT) of treatment ...
João Sérgio Neves, Carolina B. Lobato, Ana Rita Leite, Catarina Vale, Francisco Vasques‐Nóvoa, Francisca Saraiva, Adelino Leite‐Moreira, Jens J. Holst, João Pedro Ferreira   +8 more
wiley   +1 more source

New therapeutic agents for type 2 diabetes: anaesthetic considerations. A narrative review

Anaesthesiology Intensive Therapy
An increasing number of patients treated with novel antidiabetic drugs, including glucagon-like-peptide-1 receptor agonists (GLP-1RA), dual glucose-dependent insulinotropic polypeptide receptor agonists and sodium-glucose cotransporter-2 (SGLT2 ...
Oliwia Doroba, Leszek Czupryniak, Filippo Sanfilippo, Paweł Andruszkiewicz, Mateusz Zawadka   +4 more
doaj   +1 more source

Nutrition Strategies for Next‐Generation Incretin Therapies: A Systematic Scoping Review of the Current Evidence

Obesity Reviews, EarlyView.
ABSTRACT Next‐generation incretin therapies, including semaglutide and tirzepatide, have transformed obesity and Type 2 diabetes management. However, evidence‐based nutritional strategies to support safe and effective use of these agents remain limited.
Marie Spreckley, Cara F. Ruggiero, Adrian Brown   +2 more
wiley   +1 more source

Multidisciplinary Therapy to Target Obesity and Its Complications in Adult Population: A Narrative Review

Obesity Reviews, EarlyView.
ABSTRACT Obesity as a chronic and multifactorial disease requires a multidisciplinary team acting together in a holistic multitarget intervention. Multidisciplinary therapy targeting obesity and its complications includes physical exercise, nutritional, and behavior counseling.
Ana Raimunda Dâmaso, Flávia Campos Corgosinho, Deborah Cristina Landi Masquio, Nayra Figueiredo, Fabiana Kattah, Cintia Cercato, Lian Tock, Raquel Munhoz da Silveira Campos   +7 more
wiley   +1 more source

Glucose-dependent insulinotropic peptide (GIP) suppresses androgen biosynthesis in PCOS mouse models and cellular systems

Gynecological Endocrinology
Objective To assess the potential therapeutic effects of glucose-dependent insulinotropic peptide (GIP) on hyperandrogenism.Methods Polycystic ovary syndrome (PCOS) mouse models induced by dehydroepiandrosterone (DHEA) were established to evaluate the ...
Mengru Pan, Yifan Qian, Linlin Jiang, Chunwei Cao, lin li   +4 more
doaj   +1 more source

How May GIP Enhance the Therapeutic Efficacy of GLP-1?

Trends in endocrinology and metabolism, 2020
R. Samms, M. Coghlan, K. Sloop
semanticscholar   +1 more source