Results 231 to 240 of about 27,755 (279)
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Peptides, 1981
Two structurally similar peptides were isolated from a preparation of GIP using an HPLC system. The major peptide corresponds to GIP1-42 and the minor has the sequence GIP3-42. GIP1-42 has both insulinotropic and somatostatinotropic activities, whereas GIP3-42 has only insignificant activity.
J C Brown +2 more
exaly +3 more sources
Two structurally similar peptides were isolated from a preparation of GIP using an HPLC system. The major peptide corresponds to GIP1-42 and the minor has the sequence GIP3-42. GIP1-42 has both insulinotropic and somatostatinotropic activities, whereas GIP3-42 has only insignificant activity.
J C Brown +2 more
exaly +3 more sources
Peptides, 2020 Enzymatic cleavage of endogenous peptides is a commonly used principle to initiate, modulate and terminate action for instance among cytokines and peptide hormones.
Wijnand J C van der Velden +2 more
exaly +2 more sources
Glucose-dependent insulinotropic polypeptide (GIP) [PDF]
Molecular MetabolismBACKGROUND: Glucose-dependent insulinotropic polypeptide (GIP) was the first incretin identified and plays an essential role in the maintenance of glucose tolerance in healthy humans.
Ruth E Gimeno +2 more
exaly +4 more sources
Diabetologia, 2002 Aims/hypothesis: This study examined the plasma stability, biological activity and antidiabetic potential of two novel N-terminally modified analogues of gastric inhibitory polypeptide (GIP).Methods: Degradation studies were carried out on GIP, N-acetyl ...
Finbarr P M O'Harte +2 more
exaly +2 more sources
GIP or not GIP? That is the question
Trends in Pharmacological Sciences, 2003Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that is released during a meal and facilitates the disposal of both glucose and fat. Because of the insulinotropic action of GIP, this hormone has been considered as a potential therapy of type 2 diabetes, where insulin secretion is inadequate.
openaire +2 more sources
The gastrocolic response: Is it gip?
Journal of Surgical Research, 1980Abstract Previous experiments demonstrated that feeding is followed by increased electrical spike discharges and contractions of colon smooth muscle. This gastrocolic response has a definite lag period before onset, and is not due to distention of the colon by food. In these experiments, the possible association between altered serum concentration of
L F, Sillin +4 more
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Proceedings of the first workshop on Wireless mobile internet, 2001
The GPRS and UMTS specifications define the procedures supporting the mobility and the data sessions of a mobile user moving within the area of the corresponding PLMNs. For the case, though, of mobile users working in group, using a PLMN infrastructure, the aforementioned networks foresee no special treatment.
Constantinos F. Grecas +2 more
openaire +1 more source
The GPRS and UMTS specifications define the procedures supporting the mobility and the data sessions of a mobile user moving within the area of the corresponding PLMNs. For the case, though, of mobile users working in group, using a PLMN infrastructure, the aforementioned networks foresee no special treatment.
Constantinos F. Grecas +2 more
openaire +1 more source
Regulatory development of geriatric medicines: To GIP or not to GIP?
Ageing Research Reviews, 2016Geriatric patients represent the main users of medicines, but are historically often minimally included in clinical trials, resulting in a gap in the knowledge of the benefit/risk balance of medicines in this heterogeneous population. As the worldwide population is aging, the need for safe and effective medicines for older patients is proportionally ...
Bart, De Spiegeleer +6 more
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Obesity Surgery, 2010
Bariatric surgery is the most effective modality of achieving weight loss as well as the most effective treatment for type 2 diabetes mellitus (T2DM). Glucose-dependent insulinotropic polypeptide (GIP) is an incretin and is implicated in the pathogenesis of obesity and T2DM. Its role in weight loss and resolution of T2DM after bariatric surgery is very
Raghavendra S, Rao, Subhash, Kini
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Bariatric surgery is the most effective modality of achieving weight loss as well as the most effective treatment for type 2 diabetes mellitus (T2DM). Glucose-dependent insulinotropic polypeptide (GIP) is an incretin and is implicated in the pathogenesis of obesity and T2DM. Its role in weight loss and resolution of T2DM after bariatric surgery is very
Raghavendra S, Rao, Subhash, Kini
openaire +2 more sources
GIP analogues and the treatment of obesity-diabetes [PDF]
Peptides, 2020 The potential application of glucose-dependent insulinotropic polypeptide (gastric inhibitory polypeptide, GIP) in the management of obesity and type 2 diabetes has been controversial.
Clifford J Bailey
exaly +2 more sources