Results 211 to 220 of about 30,994 (308)

Dosimetric and clinical validation of a high‐density bolus for superficial skin tumors treated with radiotherapy

open access: yesJournal of Applied Clinical Medical Physics, Volume 27, Issue 8, August 2026.
Abstract Background Accurate dose deposition in superficial radiotherapy remains challenging due to the inherent skin‐sparing effect of megavoltage photon beams and difficulties in ensuring bolus conformity. Purpose This study aims to comprehensively evaluate the dosimetric characteristics of the room‐temperature‐malleable high‐density bolus, to ...
Jonathan Dadoun   +15 more
wiley   +1 more source

The Neuroprotective Potentials of Dual GIP/GLP1‐RA (Tirzepatide): From Preclinical Experiments to Clinical Trials: A Scoping Review

open access: yesBrain and Behavior, Volume 16, Issue 8, August 2026.
The graphical abstract summarizes the current evidence on the potential neuroprotective effects of tirzepatide (TZP), a dual GIP/GLP‐1 receptor agonist, across mechanistic, preclinical, and clinical domains. Mechanistically, TZP is proposed to exert direct neural effects, preserve mitochondrial function, reduce apoptosis, oxidative stress, and ...
Yousef Hawas   +6 more
wiley   +1 more source

The Mechanobiology of Adipocyte Hypertrophy: Cytoskeletal Remodelling as a Driver of Insulin Resistance in Obesity

open access: yesCell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Adipocyte hypertrophy poses an important mechanical challenge—adipocytes can increase in volume up to a thousand‐fold while still maintaining their structural integrity. Although lipid metabolism is well studied, little is known about the cytoskeletal adaptations that are required to accommodate this expansion and the resulting pathological ...
Dhakshmi Sasankan, Renu Mohan
wiley   +1 more source

Superior Cardiorenal Protection With Tirzepatide Over Dulaglutide in Heart Failure With Preserved Ejection Fraction: A Large‐Scale Propensity Score–Matched Real‐World Analysis

open access: yesClinical Cardiology, Volume 49, Issue 8, August 2026.
In this large real‐world propensity‐matched analysis, tirzepatide demonstrated superior reductions in mortality, hospitalizations, and cardiorenal outcomes versus dulaglutide in HFpEF patients, with a favorable safety profile. ABSTRACT Background No direct head‐to‐head trials compare tirzepatide and dulaglutide in heart failure with preserved ejection ...
Ibrahim Khalil   +8 more
wiley   +1 more source

Endogenous GIP signaling is indispensable for DPP-4 inhibitor-mediated metabolic control in mice. [PDF]

open access: yesJ Diabetes Investig
Kubota-Okamoto S   +17 more
europepmc   +1 more source

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