Results 221 to 230 of about 36,022 (296)

Do Fasting GLP-1 and GIP Levels Predict the Initial Pharmacological Response to Semaglutide and Tirzepatide? [PDF]

Diagnostics (Basel)
La Vignera S, Fioriglio C, Condorelli RA.   +2 more
europepmc   +1 more source

Patient Knowledge of GLP‐1 Receptor Agonists for Obesity and Exploration of Potential Household‐Level Effects in an Urban Health System

Obesity Science &Practice, Volume 12, Issue 5, October 2026.
ABSTRACT Background The use of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) for obesity management has gained widespread popularity and media attention. However, little is known about patients' knowledge related to GLP‐1 RAs (e.g., prescribing indications, side effects), how patients currently learn and wish to learn about GLP‐1 RAs, and how ...
Leah M. Schumacher, Elise Rodrigues, Erin Mraz, Doria Wohler, Astha Rajpal, Sharon J. Herring, Daniel J. Rubin, Ajay D. Rao, Laura Igarabuza, Samantha Flanagan, Daniel Edmundowicz, Resa M. Jones   +11 more
wiley   +1 more source

Simultaneous and recurrent hordeola and chalazia associated with tirzepatide therapy: a case series. [PDF]

JCEM Case Rep
Kolker A.
europepmc   +1 more source

The Bile Acid Signaling Axis: Deciphering the Roles of FXR and TGR5 in Hepatic Steatosis, Fibrosis, and Cancer

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Bile acids (BAs) serve not only as emulsifiers for lipid digestion but also as essential signaling molecules, governing various physiological and pathological processes through their interaction with the farnesoid X receptor (FXR) and the takeda G protein‐coupled receptor 5 (TGR5).
Jie Liu, Kui Sun, Hongmei Liu, Meiyang Zhu, Chunmeng Li, Yuqi He, Lin Qin   +6 more
wiley   +1 more source

Advances in the management of obesity: non-pharmacological strategies, herbal formulations, current pharmacotherapy, emerging drugs, and future perspectives. [PDF]

Front Endocrinol (Lausanne)
Mehetre KN, Dawane JS.
europepmc   +1 more source

Glucagon‐Like Peptide‐1 Agonists and Blood Pressure Regulation: Molecular Mechanisms and Cardiovascular Implications

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Incretin effect helps in regulating glucose homeostasis and maintaining glycaemic control within the human body. This effect is achieved by the two naturally occurring incretin hormones: glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1).
Nora H. J. Alharbi
wiley   +1 more source

Design of a metabolically-stable peptide therapeutic with triple-hormone-receptor agonist activity. [PDF]

J Comput Aided Mol Des
Vishnoi S, Hudson S, Bhattacharya S, Thompson D.   +3 more
europepmc   +1 more source

Sleeve Gastrectomy Improves Metabolic Health, Cognition, and Alzheimer's Disease Pathology in 3xTG Mice

Aging Cell, Volume 25, Issue 10, October 2026.
Through a single metabolic intervention, Sleeve Gastrectomy improves metabolic health and attenuates Alzheimer's pathology in 3xTg‐AD mice across dietary contexts. It reduces cortical amyloid and neuroinflammation via region‐specific brain insulin–autophagy signaling and rescues memory under Western‐diet stress, independent of caloric intake.
Reji Babygirija, Julia A. Illiano, Michelle M. Sonsalla, Grace Zhu, Christopher Retter Jabbarpour, Twinkle Mathew, Tristan Molkentin, Meredith Peterson, Carolyn Winder, Advaith Ravi Krishnan Nair, Fan Xiao, Justin M. Wolter, Dudley W. Lamming, David A. Harris   +13 more
wiley   +1 more source

β-arrestin and myosin VI cooperatively control glucose-dependent insulinotropic peptide receptor (GIPR) internalization and signaling dynamics. [PDF]

J Biol Chem
Patel NM, Sivaramakrishnan S.
europepmc   +1 more source

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source