Results 51 to 60 of about 74,465 (332)

The mitochondrial receptor complex [PDF]

, 1993
The receptor complex in the mitochondrial outer membrane, which consists of at least seven different proteins, is responsible for the recognition and translocation of cytosolically synthesized preproteins.
Alberts, Baker, Baker, Becker, Bressan, Chen, Fujiki, Hanahan, Harlow, Hartl, Hartl, Hase, Hines, Hines, Innis, Keegstra, Kiebler, Kyshe-Andersen, Kyte, Lill, Mage, Maina, Melton, Moczko, Neupert, Pelham, Pfaller, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Pfanner, Rapoport, Rassow, Rigby, Roise, Saiki, Sambrook, Sanders, Sanger, Schleyer, Schneider, Schneider, Steger, Söllner, Söllner, Söllner, Söllner, Tabor, Vestweber, von Heijne, Wickner, Wickner, Young, Zimmermann   +55 more
core   +4 more sources

Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists

Frontiers in Endocrinology
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are two incretins that bind to their respective receptors and activate the downstream signaling in various tissues and organs.
Q. Liu
semanticscholar   +1 more source

Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time

Alzheimer’s Research & Therapy, 2019
Background Subjective cognitive decline (SCD) defines a heterogeneous population, part of which having Alzheimer’s disease (AD). We aimed at characterizing SCD populations according to whether or not they referred to a memory clinic, by assessing the ...
Elizabeth Kuhn, Inès Moulinet, Audrey Perrotin, Renaud La Joie, Brigitte Landeau, Clémence Tomadesso, Alexandre Bejanin, Siya Sherif, Vincent De La Sayette, Béatrice Desgranges, Denis Vivien, Géraldine Poisnel, Gaëlle Chételat   +12 more
doaj   +1 more source

GIP-derived GIP receptor antagonists – a review of their role in GIP receptor pharmacology [PDF]

Peptides
Surprisingly, agonists, as well as antagonists of the glucose-dependent insulinotropic polypeptide receptor (GIPR), are currently being used or investigated as treatment options for type 2 diabetes and obesity - and both, when combined with glucagon-like peptide 1 receptor (GLP-1R) agonism, enhance GLP-1-induced glycemia and weight loss further.
Rosenkilde, Mette Marie, Lindquist, Peter, Kizilkaya, Hüsün Sheyma, Gasbjerg, Lærke Smidt   +3 more
openaire   +3 more sources

Modular generalized Springer correspondence III: exceptional groups [PDF]

, 2016
We complete the construction of the modular generalized Springer correspondence for an arbitrary connected reductive group, with a uniform proof of the disjointness of induction series that avoids the case-by-case arguments for classical groups used in ...
Achar, Pramod N., Henderson, Anthony, Juteau, Daniel, Riche, Simon   +3 more
core   +3 more sources

Dietary intake by patients taking GLP-1 and dual GIP/GLP-1 receptor agonists: A narrative review and discussion of research needs

Obesity Pillars
Background Obesity and type 2 diabetes mellitus (T2DM) are increasingly common in the United States and worldwide. Because both conditions are associated with serious health consequences, weight reduction is recommended by professional medical and ...
Sandra M. Christensen, Katie Robinson, Sara Thomas, Dominique R. Williams   +3 more
semanticscholar   +1 more source

Effects of endogenous GIP in patients with type 2 diabetes.

European Journal of Endocrinology, 2021
OBJECTIVE The insulinotropic effect of exogenous, intravenously infused glucose-dependent insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated the effects of endogenous GIP in relation to glucose and bone metabolism
Signe Stensen, L. Gasbjerg, L. L. Krogh, Kirsa Skov-Jeppesen, A. H. Sparre-Ulrich, M. Jensen, F. Dela, B. Hartmann, T. Vilsbøll, J. Holst, M. Rosenkilde, M. Christensen, F. Knop   +12 more
semanticscholar   +1 more source

The evolution of the therapeutic concept ‘GIP receptor antagonism’

Frontiers in Endocrinology
Glucose-dependent insulinotropic polypeptide (GIP) is an intestinal hormone that potentiates glucose-induced insulin secretion in the postprandial state. GIP exerts a broad range of other physiological actions e.g.
Frederikke Koefoed-Hansen, Frederikke Koefoed-Hansen, Mads Marstrand Helsted, Hüsün Sheyma Kizilkaya, Asger Bach Lund, Asger Bach Lund, Asger Bach Lund, Mette Marie Rosenkilde, Lærke Smidt Gasbjerg, Lærke Smidt Gasbjerg   +9 more
doaj   +1 more source

Brain and cognitive correlates of sleep fragmentation in elderly subjects with and without cognitive deficits

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Sleep disturbances are increasingly recognized as a risk factor for Alzheimer's disease. However, no study has assessed the relationships between objective sleep fragmentation (SF) and brain and cognitive integrity across different cognitive
Claire André, Clémence Tomadesso, Robin deFlores, Pierre Branger, Stéphane Rehel, Florence Mézenge, Brigitte Landeau, Vincent de laSayette, Francis Eustache, Gaël Chételat, Géraldine Rauchs   +10 more
doaj   +1 more source

Absorptive capacity and relationship learning mechanisms as complementary drivers of green innovation performance [PDF]

, 2018
This paper aims to explore in depth how internal and external knowledge-based drivers actually affect the firms\u2019 green innovation performance. Subsequently, this study analyzes the relationships between absorptive capacity (internal knowledge-based ...
Albort-Morant, Gema, De Marchi, Valentina, Leal-Rodr\uedguez, Antonio L.   +2 more
core   +1 more source