Results 51 to 60 of about 30,994 (308)

A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control. [PDF]

PLoS ONE, 2010
AIMS:The gastrointestinal hormone GIP promotes pancreatic islet function and exerts pro-survival actions on cultured beta-cells. However, GIP also promotes lipogenesis, thus potentially restricting its therapeutic use.
Scott B Widenmaier, Su-Jin Kim, Gary K Yang, Thomas De Los Reyes, Cuilan Nian, Ali Asadi, Yutaka Seino, Timothy J Kieffer, Yin Nam Kwok, Christopher H S McIntosh   +9 more
doaj   +1 more source

Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP

Drug Design, Development and Therapy, 2022
Lijing Wang College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Lijing Wang, College of Life Science and Technology, China Pharmaceutical University, 639 Longmian ...
Wang L
doaj  

Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time

Alzheimer’s Research & Therapy, 2019
Background Subjective cognitive decline (SCD) defines a heterogeneous population, part of which having Alzheimer’s disease (AD). We aimed at characterizing SCD populations according to whether or not they referred to a memory clinic, by assessing the ...
Elizabeth Kuhn, Inès Moulinet, Audrey Perrotin, Renaud La Joie, Brigitte Landeau, Clémence Tomadesso, Alexandre Bejanin, Siya Sherif, Vincent De La Sayette, Béatrice Desgranges, Denis Vivien, Géraldine Poisnel, Gaëlle Chételat   +12 more
doaj   +1 more source

The Location of Missense Variants in the Human GIP Gene Is Indicative for Natural Selection

Frontiers in Endocrinology, 2022
The intestinal hormone, glucose-dependent insulinotropic polypeptide (GIP), is involved in important physiological functions, including postprandial blood glucose homeostasis, bone remodeling, and lipid metabolism.
Peter Lindquist, Lærke Smidt Gasbjerg, Jacek Mokrosinski, Jens Juul Holst, Jens Juul Holst, Alexander Sebastian Hauser, Mette Marie Rosenkilde   +6 more
doaj   +1 more source

Glucose-Dependent Insulinotropic Polypeptide Suppresses Foam Cell Formation of Macrophages through Inhibition of the Cyclin-Dependent Kinase 5-CD36 Pathway

Biomedicines, 2021
Glucose-dependent insulinotropic polypeptide (GIP) has been reported to have an atheroprotective property in animal models. However, the effect of GIP on macrophage foam cell formation, a crucial step of atherosclerosis, remains largely unknown.
Michishige Terasaki, Hironori Yashima, Yusaku Mori, Tomomi Saito, Yoshie Shiraga, Raichi Kawakami, Makoto Ohara, Tomoyasu Fukui, Tsutomu Hirano, Yuichiro Yamada, Yutaka Seino, Sho-ichi Yamagishi   +11 more
doaj   +1 more source

Mechanisms of action and therapeutic applications of GLP-1 and dual GIP/GLP-1 receptor agonists

Frontiers in Endocrinology
Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are two incretins that bind to their respective receptors and activate the downstream signaling in various tissues and organs.
Q. Liu
semanticscholar   +1 more source

Dose- and time-dependent effects of the dual GIP/GLP-1 receptor agonist tirzepatide on emotional overeating in a rat model of intracranial self-stimulation

Acta Biomedica Scientifica
Background. Despite the increasing prevalence of emotional overeating and obesity, the specific neurohormonal mechanisms involved in the pathogenesis of these pathological processes remain poorly understood.
N. S. Dedanishvili, S. S. Pyurveev, T. V. Brus, A. G. Vasiliev   +3 more
doaj   +1 more source

Dietary intake by patients taking GLP-1 and dual GIP/GLP-1 receptor agonists: A narrative review and discussion of research needs

Obesity Pillars
Background Obesity and type 2 diabetes mellitus (T2DM) are increasingly common in the United States and worldwide. Because both conditions are associated with serious health consequences, weight reduction is recommended by professional medical and ...
Sandra M. Christensen, Katie Robinson, Sara E Thomas, Dominique R. Williams   +3 more
semanticscholar   +1 more source

Glucose-dependent insulinotropic polypeptide - a new link in the development of obesity

Ожирение и метаболизм, 2015
Objective. Glucose-dependent insulinotropic polypeptide (GIP) as well as glucagon-like peptide-1 (GLP-1) is intestinal incretin hormone that stimulates insulin secretion in response to feeding. Much evidence of GIP contribution to obesity development has
Ekaterina Alekseevna Shestakova, Aleksandr Victorovich Il'in, Marina Vladimirovna Shestakova, Ivan Ivanovich Dedov   +3 more
doaj   +1 more source

The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes

Сахарный диабет, 2015
Background. The main aims of the conservative treatment of metabolic obesity (MО) are weight loss and the prevention of type 2 diabetes. Incretin-based drugs are considered to be effective and safe and stimulate insulin secretion via the β-cells of the ...
Elena Vital'evna Kirienkova, Mariia Aleksandrovna Vasilenko, Pavel Anatol'evich Zatolokin, Nataliya Ivanovna Mironyuk, Dar'ya Aleksandrovna Skuratovskaia, Larisa Sergeevna Litvinova   +5 more
doaj   +1 more source