Results 41 to 50 of about 36,022 (296)

GIP-(3-42) does not antagonize insulinotropic effects of GIP at physiological concentrations.

, 2006
Udgivelsesdato: 2006-SepGlucose-dependent insulinotropic polypeptide [GIP-(1-42)] is degraded by dipeptidyl peptidase IV (DPP IV), forming GIP-(3-42). In mice, high concentrations of synthetic GIP-(3-42) may function as a GIP receptor antagonist, but it ...
Mette M. Rosenkilde, Rosenkilde, Mette M, Holst, Jens J, Carolyn F. Deacon, Jocelyn de Heer, Jens J. Holst, Astrid Plamboeck, Plamboeck, Astrid, de Heer, Jocelyn, Deacon, Carolyn F   +9 more
core   +1 more source

Gip, an Intestinal Metabolic Hormone. [PDF]

, 2020
Using an established radioimmunoassay for immunoreactive gastric inhibitory polypeptide (IR-GIP) the metabolic actions of gastric inhibitory polypeptide (GIP) were investigated.
Kwasowski, Piotr.
core  

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source

Central GIP signaling stimulates peripheral GIP release and promotes insulin and pancreatic polypeptide secretion in nonhuman primates [PDF]

, 2016
Glucosedependent insulinotropic polypeptide (GIP) has important actions on whole body metabolic function. GIP and its receptor are also present in the central nervous system and have been linked to neurotrophic actions.
Tejero, M. Elizabeth, I. P. Rodríguez Sánchez, P. B. Higgins, S. A. Cole, M. Garcia Forey, M. . E. Tejero, Voruganti, V. Saroja, F. Folli, R. E. Shade, Rodríguez-Sánchez, Irám P., V. . S. Voruganti, Comuzzie, Anthony G., Higgins, Paul B., Shade, Robert E., Cole, Shelley A., A. G. Comuzzie, Folli, Franco, Garcia-Forey, Magdalena   +17 more
core   +2 more sources

PANCREATIC AND EXTRA-PANCREATIC EFFECTS OF INCRETINS AND PERSPECTIVES FOR STUDYING ENTEROINSULIN HORMONAL SYSTEM DURING GESTATIONAL DISORDER OF CARBOHYDRATE METABOLISM

Бюллетень сибирской медицины, 2013
The absence of an ideal medicine for the treatment of patients with type 2 diabetes, that would be able to provide not only high quality and constant monitoring of glycemia without increasing body weight, with no risk of hypoglycemia, with no negative ...
T. V. Saprina, Ye. S. Timokhina, N. N. Musina, T. S. Prokhorenko, L. A. Tashireva, O. K. Goncharevich   +5 more
doaj   +1 more source

Het GIP Tg mice retain responsiveness to GIP. A. Plasma GIP levels.

, 2012
After 13 weeks of LF or HF diet feeding, circulating GIP levels were determined in Het GIP Tg and WT littermates (n = 5∼6/group). B and D. Effects of GIP on glycemic excursions in LF (B)- and HF (D) diet-fed Het GIP Tg and WT littermates.
Carlos M. Isales (154141), Susanne M. Clee (154135), Su-Jin Kim (90561), Subashini Karunakaran (154128), Christopher H. S. McIntosh (154145), Cuilan Nian (154120)   +5 more
core   +1 more source

Integration of Nutrition and Organic Agriculture Framework in Managing Gastrointestinal Nematodes in Ruminants

Animal Research and One Health, EarlyView.
Gastrointestinal nematode infections damage the gastrointestinal epithelial tissues of ruminants, affecting nutrient utilization and overall production performance. This review outlines host‐gastrointestinal nematode interactions and discusses integrated control strategies, including nutritional supplementation, grazing management, vaccines, and ...
Wenxun Chen, Xiangfang Tang, Yimin Zhuang, Shengjun Zhao, Ying Ren, Xiaokang Lv   +5 more
wiley   +1 more source

Structural and molecular determinants of medial temporal lobe network vulnerability in aging and Alzheimer’s disease

Alzheimer’s Research & Therapy
Background The medial temporal lobe is organized into two memory-critical networks: the anterior–temporal and posterior–medial systems. While these systems show selective vulnerability to aging and Alzheimer’s disease, the underlying structural and ...
Elise Saul, Léa Chauveau, Brigitte Landeau, Jade Lasserve, Blandine Montagne, Emilie Foyard, Géraldine Poisnel, Gaël Chételat, Robin de Flores, for the Medit-Ageing Research Group   +9 more
doaj   +1 more source

Gut Health in Ostriches (Struthio camelus): Insights Into Intestinal Structure, Functions, Microbiome, and Improvement Strategies

Animal Research and One Health, EarlyView.
Our paper systematically reviews the intestinal structure, function, and microbiota of ostriches, along with strategies for improving their gut health. We analyze how these factors collectively influence intestinal homeostasis and ostrich welfare, emphasizing probiotics as a promising intervention to enhance gut health, boost population well‐being, and
Zi‐Qun Zhang, Fang‐Fang Guo, Wen‐Juan Du, Meng Li, Aftab Shaukat, Zhu‐Qing Jia, Shu‐Cheng Huang   +6 more
wiley   +1 more source

Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women

Endocrine Connections
Background/objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells in response to nutrient ingestion. The aims of this study were: i) to evaluate the cross-sectional associations between plasma GIP change in ...
Isidora Salvatierra, Javier Parada, Rodrigo Cataldo, José Eduardo Galgani, Gigliola Alberti, Idoia Labayen, José L Santos   +6 more
doaj   +1 more source