Results 21 to 30 of about 30,994 (308)

Manufacture of Tl targets by electrodeposition for the study of excitation functions of 203Pb [PDF]

EPJ Web of Conferences, 2023
Natural Tl targets were manufactured by electrochemical deposition on a foil gold backing. The electrochemical parameters were defined after several experiments and reverse pulse potential was chosen to avoid the formation of filaments and dendrites ...
Sounalet Thomas, Alliot Cyrille, Audouin Nadia, Bozovic Nicolas, Brelet Fabien, Dureau Remy, Guertin Arnaud, Haddad Ferid, Kamalakannan Keerthana, Nigron Etienne, Tarinas Maryne   +10 more
doaj   +1 more source

Metabolic, hormonal and performance effects of isomaltulose ingestion before prolonged aerobic exercise: a double-blind, randomised, cross-over trial

Journal of the International Society of Sports Nutrition, 2021
Background Isomaltulose has been discussed as a low glycaemic carbohydrate but evidence concerning performance benefits and physiological responses has produced varying results.
Hannah L. Notbohm, Joshua F. Feuerbacher, Finn Papendorf, Nils Friese, Mats W. Jacobs, Hans-Georg Predel, Jonas Zacher, Wilhelm Bloch, Moritz Schumann   +8 more
doaj   +1 more source

The glucose-dependent insulinotropic polypeptide (GIP) regulates body weight and food intake via CNS-GIPR signaling

Cell Metabolism, 2021
Summary Uncertainty exists as to whether the glucose-dependent insulinotropic polypeptide receptor (GIPR) should be activated or inhibited for the treatment of obesity. Gipr was recently demonstrated in hypothalamic feeding centers, but the physiological
Qian Zhang, Challa Tenagne Delessa, R. Augustin, Mostafa Bakhti, G. Colldén, D. Drucker, A. Feuchtinger, C. Cáceres, Gerald Grandl, A. Harger, S. Herzig, S. Hofmann, C. Holleman, M. Jastroch, S. Keipert, M. Kleinert, P. Knerr, Konxhe Kulaj, B. Legutko, H. Lickert, Xue Liu, G. Luippold, D. Lutter, Emilija Malogajski, Marta Tarquis Medina, Stephanie A. Mowery, A. Blutke, D. Perez-Tilve, Ciro Salinno, Laura Sehrer, R. DiMarchi, M. Tschöp, K. Stemmer, Brian Finan, C. Wolfrum, T. Müller   +35 more
semanticscholar   +1 more source

GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function.

Cell Reports, 2023
Glucagon-like peptide 1 (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIPR) receptors are G-protein-coupled receptors involved in glucose homeostasis. Diabetogenic conditions decrease β-arrestin 2 (ARRB2) levels in human islets.
Nour Zaïmia, J. Obeid, A. Varrault, Julia Sabatier, C. Broca, P. Gilon, S. Costes, G. Bertrand, M. Ravier   +8 more
semanticscholar   +1 more source

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

JCI Insight, 2020
Tirzepatide (LY3298176) is a dual GIP and GLP-1 receptor agonist under development for the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis.
F. Willard, J. Douros, M. Gabe, A. D. Showalter, D. Wainscott, T. Suter, M. Capozzi, W. J. C. van der Velden, Cynthia Stutsman, G. Cardona, S. Urva, P. Emmerson, J. Holst, D. D’Alessio, M. Coghlan, M. Rosenkilde, Jonathan E. Campbell, K. Sloop   +17 more
semanticscholar   +1 more source

GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells.

European Journal of Endocrinology, 2023
OBJECTIVE Drugs targeting the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) are emerging as treatments for type-2 diabetes and obesity.
Morten S. Hansen, K. Søe, L. L. Christensen, Paula Fernandez-Guerra, N. W. Hansen, R. Wyatt, C. Martin, R. Hardy, T. L. Andersen, J. B. Olesen, B. Hartmann, M. Rosenkilde, M. Kassem, Alexander Rauch, C. Gorvin, M. Frost   +15 more
semanticscholar   +1 more source

Glucose metabolism and incretins level in morbidly obese patients and in patients after biliopancreatic diversion performed for morbid obesity

Ожирение и метаболизм, 2014
We’ve studied a carbohydrate metabolism in morbidly obese (MO) patients and the patients after bariatric surgery. The patients of the 1st group had BMI>40 (n=22) and no history of diabetes mellitus.

doaj   +1 more source

Potential of using polyethylene as viscosity enhancer of palm oil to use as a lubricating oil

Advances in Mechanical Engineering, 2020
Biodegradable vegetable oil-based lubricating oil is a better auxiliary for mineral-based lubricants as their viscosity index, flash point, lubricity is high.
TKKS Pathmasiri, GIP Perera
doaj   +1 more source

Imaging modalities to assess oxygen status in glioblastoma

Frontiers in Medicine, 2015
Hypoxia, the result of an inadequacy between a disorganized and functionally impaired vasculature and the metabolic demand of tumor cells is a feature of glioblastoma.
Aurélien eCorroyer-Dulmont, Aurélien eCorroyer-Dulmont, Aurélien eCorroyer-Dulmont, Aurélien eCorroyer-Dulmont, Ararat eChakhoyan, Ararat eChakhoyan, Ararat eChakhoyan, Ararat eChakhoyan, Solene eCollet, Solene eCollet, Solene eCollet, Solene eCollet, Lucile eDurand, Lucile eDurand, Lucile eDurand, Lucile eDurand, Eric T MacKenzie, Eric T MacKenzie, Eric T MacKenzie, Eric T MacKenzie, Edwige ePetit, Edwige ePetit, Edwige ePetit, Edwige ePetit, Myriam eBernaudin, Myriam eBernaudin, Myriam eBernaudin, Myriam eBernaudin, Omar eTouzani, Omar eTouzani, Omar eTouzani, Omar eTouzani, Samuel eValable, Samuel eValable, Samuel eValable, Samuel eValable   +35 more
doaj   +1 more source

How May GIP Enhance the Therapeutic Efficacy of GLP-1?

Trends in endocrinology and metabolism, 2020
Glucagon-like peptide-1 (GLP-1) receptor agonists improve glucose homeostasis, reduce bodyweight, and over time benefit cardiovascular health in type 2 diabetes mellitus (T2DM). However, dose-related gastrointestinal effects limit efficacy, and therefore
R. Samms, M. Coghlan, K. Sloop
semanticscholar   +1 more source