Results 11 to 20 of about 74,465 (332)

Metabolic, hormonal and performance effects of isomaltulose ingestion before prolonged aerobic exercise: a double-blind, randomised, cross-over trial

Journal of the International Society of Sports Nutrition, 2021
Background Isomaltulose has been discussed as a low glycaemic carbohydrate but evidence concerning performance benefits and physiological responses has produced varying results.
Hannah L. Notbohm, Joshua F. Feuerbacher, Finn Papendorf, Nils Friese, Mats W. Jacobs, Hans-Georg Predel, Jonas Zacher, Wilhelm Bloch, Moritz Schumann   +8 more
doaj   +1 more source

GLP-1 and GIP receptors signal through distinct β-arrestin 2-dependent pathways to regulate pancreatic β cell function.

Cell Reports, 2023
Glucagon-like peptide 1 (GLP-1R) and glucose-dependent insulinotropic polypeptide (GIPR) receptors are G-protein-coupled receptors involved in glucose homeostasis. Diabetogenic conditions decrease β-arrestin 2 (ARRB2) levels in human islets.
Nour Zaïmia, J. Obeid, A. Varrault, Julia Sabatier, C. Broca, P. Gilon, S. Costes, G. Bertrand, M. Ravier   +8 more
semanticscholar   +1 more source

Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist

JCI Insight, 2020
Tirzepatide (LY3298176) is a dual GIP and GLP-1 receptor agonist under development for the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis.
F. Willard, J. Douros, M. Gabe, A. D. Showalter, D. B. Wainscott, T. Suter, M. Capozzi, W. J. C. van der Velden, Cynthia Stutsman, G. Cardona, S. Urva, P. Emmerson, J. Holst, D. D’Alessio, M. Coghlan, M. Rosenkilde, Jonathan E. Campbell, K. Sloop   +17 more
semanticscholar   +1 more source

GIP reduces osteoclast activity and improves osteoblast survival in primary human bone cells.

European Journal of Endocrinology, 2023
OBJECTIVE Drugs targeting the glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) are emerging as treatments for type-2 diabetes and obesity.
Morten S. Hansen, K. Søe, L. L. Christensen, Paula Fernandez-Guerra, N. W. Hansen, R. Wyatt, C. Martin, R. Hardy, T. L. Andersen, J. B. Olesen, B. Hartmann, M. Rosenkilde, M. Kassem, Alexander Rauch, C. Gorvin, M. Frost   +15 more
semanticscholar   +1 more source

Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.

Cell Metabolism, 2021
Unimolecular triple incretins, combining the activity of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG), have demonstrated reduction in body weight and improved glucose control in rodent models. We
M. Bossart, Michael Wagner, Ralf Elvert, A. Evers, T. Hübschle, Tim Kloeckener, K. Lorenz, Christine Moessinger, O. Eriksson, I. Velikyan, S. Pierrou, Lars Johansson, Gabriele Dietert, Yasmin Dietz-Baum, Thomas Kissner, Irene Nowotny, Christine Einig, Christelle Jan, Faiza Rharbaoui, Johann Gassenhuber, Hans-Peter Prochnow, I. Agueusop, N. Pørksen, William B. Smith, A. Nitsche, A. Konkar   +25 more
semanticscholar   +1 more source

Glucose metabolism and incretins level in morbidly obese patients and in patients after biliopancreatic diversion performed for morbid obesity

Ожирение и метаболизм, 2014
We’ve studied a carbohydrate metabolism in morbidly obese (MO) patients and the patients after bariatric surgery. The patients of the 1st group had BMI>40 (n=22) and no history of diabetes mellitus.

doaj   +1 more source

GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells

Science Advances, 2021
GIPR activity in α cells is required for the complete metabolic response to a meal. Glucose-dependent insulinotropic polypeptide (GIP) communicates nutrient intake from the gut to islets, enabling optimal levels of insulin secretion via the GIP receptor (
K. El, S. Gray, M. Capozzi, E. Knuth, E. Jin, B. Svendsen, A. Clifford, J. Brown, S. Encisco, B. M. Chazotte, K. Sloop, D. J. Nunez, M. Merrins, D. D’Alessio, J. E. Campbell   +14 more
semanticscholar   +1 more source

Multimodal evaluation of hypoxia in brain metastases of lung cancer and interest of hypoxia image-guided radiotherapy

Scientific Reports, 2021
Lung cancer patients frequently develop brain metastases (BM). Despite aggressive treatment including neurosurgery and external-radiotherapy, overall survival remains poor.
Aurélien Corroyer-Dulmont, Samuel Valable, Jade Fantin, Laurent Chatre, Jérôme Toutain, Sylvain Teulier, Céline Bazille, Elise Letissier, Jérôme Levallet, Didier Divoux, Méziane Ibazizène, Stéphane Guillouet, Cécile Perrio, Louisa Barré, Sébastien Serres, Nicola R. Sibson, Françoise Chapon, Guénaëlle Levallet, Myriam Bernaudin   +18 more
doaj   +1 more source

Imaging modalities to assess oxygen status in glioblastoma

Frontiers in Medicine, 2015
Hypoxia, the result of an inadequacy between a disorganized and functionally impaired vasculature and the metabolic demand of tumor cells is a feature of glioblastoma.
Aurélien eCorroyer-Dulmont, Aurélien eCorroyer-Dulmont, Aurélien eCorroyer-Dulmont, Aurélien eCorroyer-Dulmont, Ararat eChakhoyan, Ararat eChakhoyan, Ararat eChakhoyan, Ararat eChakhoyan, Solene eCollet, Solene eCollet, Solene eCollet, Solene eCollet, Lucile eDurand, Lucile eDurand, Lucile eDurand, Lucile eDurand, Eric T MacKenzie, Eric T MacKenzie, Eric T MacKenzie, Eric T MacKenzie, Edwige ePetit, Edwige ePetit, Edwige ePetit, Edwige ePetit, Myriam eBernaudin, Myriam eBernaudin, Myriam eBernaudin, Myriam eBernaudin, Omar eTouzani, Omar eTouzani, Omar eTouzani, Omar eTouzani, Samuel eValable, Samuel eValable, Samuel eValable, Samuel eValable   +35 more
doaj   +1 more source

Gluten Immunogenic Peptides as Standard for the Evaluation of Potential Harmful Prolamin Content in Food and Human Specimen [PDF]

, 2018
Gluten is a complex mixture of storage proteins in cereals like wheat, barley, and rye. Prolamins are the main components of gluten. Their high content in proline and glutamine makes them water-insoluble and difficult to digest in the gastrointestinal ...
Cebolla Ramírez, Ángel, Coto, Laura, Moreno Amador, María de Lourdes, Sousa Martín, Carolina   +3 more
core   +1 more source