Results 11 to 20 of about 36,022 (296)

GIP-derived GIP receptor antagonists – a review of their role in GIP receptor pharmacology

Peptides
Surprisingly, agonists, as well as antagonists of the glucose-dependent insulinotropic polypeptide receptor (GIPR), are currently being used or investigated as treatment options for type 2 diabetes and obesity - and both, when combined with glucagon-like peptide 1 receptor (GLP-1R) agonism, enhance GLP-1-induced glycemia and weight loss further.
Rosenkilde, Mette Marie, Lindquist, Peter, Kizilkaya, Hüsün Sheyma, Gasbjerg, Lærke Smidt   +3 more
openaire   +4 more sources

Tirzepatide, GIP(1-42) and GIP(1-30) display unique signaling profiles at two common GIP receptor variants, E354 and Q354 [PDF]

Frontiers in Pharmacology
Type 2 diabetes (T2D) and obesity are prevalent metabolic disorders affecting millions of individuals worldwide. A new effective therapeutic drug called tirzepatide for the treatment of obesity and T2D is a dual agonist of the GIP receptor and GLP-1 ...
Tayla A. Rees, Tayla A. Rees, Tayla A. Rees, Benjamin J. Buttle, Zoe Tasma, Zoe Tasma, Sung-Hyun Yang, Paul W. R. Harris, Paul W. R. Harris, Paul W. R. Harris, Christopher S. Walker, Christopher S. Walker   +11 more
doaj   +3 more sources

The evolution of the therapeutic concept ‘GIP receptor antagonism’ [PDF]

Frontiers in Endocrinology
Glucose-dependent insulinotropic polypeptide (GIP) is an intestinal hormone that potentiates glucose-induced insulin secretion in the postprandial state. GIP exerts a broad range of other physiological actions e.g.
Frederikke Koefoed-Hansen, Frederikke Koefoed-Hansen, Mads Marstrand Helsted, Hüsün Sheyma Kizilkaya, Asger Bach Lund, Asger Bach Lund, Asger Bach Lund, Mette Marie Rosenkilde, Lærke Smidt Gasbjerg, Lærke Smidt Gasbjerg   +9 more
doaj   +3 more sources

GeoEra-GIP/WP4-Semantics: GeoERA-GIP/WP4-Semantics

, 2023
<p>The published "WP4-Semantics - GitHub repository" was to manage work package nr 4 of the GeoERA Information Platform Project (GIP-P). The main goals of the framework were (1) creating a "Keyword Thesaurus" for Geosciences, (2)
Martin Schiegl, Christine, KoalaGeo
core   +1 more source

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]

, 2011
Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Beat Müller, Tanja Radimerski, Ralph Peterli, Ulrich Keller, Christ-Crain, Mirjam, Daniel M. Frey, Timper, Katharina, Frey, Daniel M., Mirjam Christ-Crain, Jean Grisouard, Häring, Andreas, Zulewski, Henryk, Keller, Ulrich, Grisouard, Jean, Katharina Timper, Henryk Zulewski, Radimerski, Tanja, Müller, Beat, Kaethi Dembinski, Dembinski, Kaethi, Andreas Häring, Peterli, Ralph   +21 more
core   +1 more source

Metabolic effects of diets differing in glycaemic index depend on age and endogenous GIP [PDF]

, 2009
Aims/hypothesis High- vs low-glycaemic index (GI) diets unfavourably affect body fat mass and metabolic markers in rodents. Different effects of these diets could be age-dependent, as well as mediated, in part, by carbohydrate-induced stimulation of ...
Isken, Frank, Weickert, Martin O., Pfeiffer, Andreas F. H., Möhlig, Matthias, Abdelrahman, A., Thorens, B., Klaus, Susanne, Nogueiras, R., Tschöp, M. H.   +8 more
core   +1 more source

An enzymatically stable GIP/xenin hybrid peptide restores GIP sensitivity, enhances beta cell function and improves glucose homeostasis in high-fat-fed mice [PDF]

, 2016
AIMS/HYPOTHESIS: Glucose-dependent insulinotropic polypeptide (GIP) and xenin, regulatory gut hormones secreted from enteroendocrine K cells, exert important effects on metabolism. In addition, xenin potentiates the biological actions of GIP. The present
Gault, Victor A, Hasib, Annie, Parthsarathy, Vadivel, Dawood Khan, Nigel Irwin, Annie Hasib, Peter R. Flatt, Victor A. Gault, Khan, Dawood, Flatt, Peter, Ng, Tony, Ming T. Ng, Vadivel Parthsarathy, Irwin, Nigel, Gault, Victor A., Ng, Ming T.   +15 more
core   +2 more sources

GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release [PDF]

, 2017
Alternative processing of the precursor protein pro-GIP results in endogenously produced GIP(1-30)NH2, that by DPP-4 cleavage in vivo results in the metabolite GIP(3-30)NH2.
B Hartmann, Gasbjerg, L S, Svendsen, B, Rosenkilde, M M, L.S. Gasbjerg, M.N. Gabe, Hartmann, B, J.J. Holst, Gabe, M N, M.M. Rosenkilde, Sparre-Ulrich, A H, B. Svendsen, Holst, J J, C.B. Christiansen, A.H. Sparre-Ulrich, Christiansen, C B   +15 more
core   +1 more source

Gluten Immunogenic Peptides (GIP) Point-of-Care Urine Test in Coeliac Disease Follow-up before and during the COVID-19 Lockdown in Italy

Clinical and Experimental Gastroenterology, 2021
Carolina Ciacci,1 Mario Gagliardi,1 Monica Siniscalchi,1 Monica Ruotolo,1 Antonella Santonicola,1 Najla Hajji,1 Fabiana Zingone2 1Celiac Center at Department of Medicine, Surgery, and Dentistry, Scuola Medica Salernitana, University of Salerno, Salerno ...
Ciacci C, Gagliardi M, Siniscalchi M, Ruotolo M, Santonicola A, Hajji N, Zingone F   +6 more
doaj  

Effects of GLP-1 receptor agonists and dual incretin agonists on adipocyte type and size [PDF]

Exploration of Endocrine and Metabolic Diseases
Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs) and dual incretin agonists have demonstrated significant potential in improving adipose tissue function beyond their established effects on appetite suppression and weight loss.
Nino Turashvili
doaj   +1 more source