Results 31 to 40 of about 36,022 (296)

Glucagon‐Like Peptide‐1 Receptor Agonists in Multiple Sclerosis: A Topical Narrative Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The glucagon‐like peptide‐1 (GLP‐1) receptor agonists (RAs) are a relatively new class of drugs that were initially approved by the US Food and Drug Administration to improve glycemic control in patients with type 2 diabetes mellitus and, subsequently, weight reduction in patients with obesity.
Audrey Y. Chang, Farrah J. Mateen
wiley   +1 more source

The postprandial dynamics of gastroduodenal zone hormones in patients with metabolic obesity associated or not associated with type 2 diabetes

Сахарный диабет, 2015
Background. The main aims of the conservative treatment of metabolic obesity (MО) are weight loss and the prevention of type 2 diabetes. Incretin-based drugs are considered to be effective and safe and stimulate insulin secretion via the β-cells of the ...
Elena Vital'evna Kirienkova, Mariia Aleksandrovna Vasilenko, Pavel Anatol'evich Zatolokin, Nataliya Ivanovna Mironyuk, Dar'ya Aleksandrovna Skuratovskaia, Larisa Sergeevna Litvinova   +5 more
doaj   +1 more source

Glucose-Dependent Insulinotropic Polypeptide Suppresses Foam Cell Formation of Macrophages through Inhibition of the Cyclin-Dependent Kinase 5-CD36 Pathway

Biomedicines, 2021
Glucose-dependent insulinotropic polypeptide (GIP) has been reported to have an atheroprotective property in animal models. However, the effect of GIP on macrophage foam cell formation, a crucial step of atherosclerosis, remains largely unknown.
Michishige Terasaki, Hironori Yashima, Yusaku Mori, Tomomi Saito, Yoshie Shiraga, Raichi Kawakami, Makoto Ohara, Tomoyasu Fukui, Tsutomu Hirano, Yuichiro Yamada, Yutaka Seino, Sho-ichi Yamagishi   +11 more
doaj   +1 more source

EAT-GIP data.sav

, 2023
EAT ...
Zhen Chen (16984878)
core   +1 more source

Charting Endocrine Progenitors Across Species and Organs

Advanced Science, EarlyView.
Endocrine progenitors give rise to the hormone‐producing cells of the pancreas and intestine. Using single‐cell multiomics and proteomics, this study compares these progenitors across species, systems, and organs, mapping the conserved and species‐specific gene regulatory networks that guide their formation.
Changying Jing, Michael Sterr, Özüm Sehnaz Caliskan, Lama Saber, Nicole Katarina Rogers, Samuel Ogden, Kei Kozawa, Christos Karampelias, Jessica Jaki, Aimée Bastidas‐Ponce, Falk Janos Farkas, Oliver Czarnecki, Osvaldo Rodrigues Pereira, Perla Cota, Valerie Vandenbempt, Diego Balboa, Anika Böttcher, Natalie Krahmer, Mohammad Lotfollahi, Julie B. Sneddon, Heiko Lickert, Mostafa Bakhti   +21 more
wiley   +1 more source

Brain and cognitive correlates of sleep fragmentation in elderly subjects with and without cognitive deficits

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Sleep disturbances are increasingly recognized as a risk factor for Alzheimer's disease. However, no study has assessed the relationships between objective sleep fragmentation (SF) and brain and cognitive integrity across different cognitive
Claire André, Clémence Tomadesso, Robin deFlores, Pierre Branger, Stéphane Rehel, Florence Mézenge, Brigitte Landeau, Vincent de laSayette, Francis Eustache, Gaël Chételat, Géraldine Rauchs   +10 more
doaj   +1 more source

Inorganic Nanomaterials can Promote or Inhibit Tumor Metastasis Depending on Tumor Microenvironment Composition

Advanced Science, EarlyView.
As engineered nanomaterials gain prominence in cancer imaging and therapy, understanding their impact on tumor progression becomes increasingly critical. We demonstrate that gold and silica‐coated gold nanomaterials can either suppress or enhance breast cancer metastasis through distinct tumor microenvironment interactions, while identifying ...
Kiana Buttiens, Xiaoqi Zheng, Xueqi Fan, Mukaddes Izci, Christy Maksoudian, Irati Perez Gilabert, Tianjiao Chu, Filipa Goncalves, Jonas Dehairs, Johan Swinnen, Bella B. Manshian, Stefaan J. Soenen   +11 more
wiley   +1 more source

Incretin-based therapies for cardio-kidney-liver-metabolic disease: the role of the liver in the modern era of chronic disease management [PDF]

Clinical and Molecular Hepatology
Steatotic liver disease (SLD) is a leading cause of disease globally and demands new therapeutic approaches to mitigate underlying metabolic dysregulation. Incretin-based therapies are emerging as a viable prospect to fulfil this unmet niche.
Harendran Elangovan, Rohit Loomba, Mark Muthiah, Jörn Schattenberg, Ming Hua Zheng, Mazen Noureddin, Christos Mantzoros, Jacob George   +7 more
doaj   +1 more source

Gastric inhibitory polypeptide (GIP) is selectively decreased in the roux-limb of dietary obese mice after RYGB surgery. [PDF]

PLoS ONE, 2015
Gastric inhibitory polypeptide (GIP, glucose-dependent insulinotropic polypeptide) is expressed by intestinal K cells to regulate glucose-induced insulin secretion. The impact of Roux-en Y bypass (RYGB) surgery on blood GIP is highly contraversial.
Jiaqiang Zhou, Zheng Hao, Nigel Irwin, Hans-Rudolf Berthoud, Jianping Ye   +4 more
doaj   +1 more source

Avaliação da expressão do peptídeo insulinotrópico dependente de glicose (GIP) e do seu receptor na medula espinal de animais submetidos ao modelo experimental de lesão medular traumática induzida por compressão [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Ciências Médicas, Florianópolis, 2011A lesão traumática da medula espinal (LTME) desencadeia uma síndrome neurológica altamente ...
Marcos, Ana Beatriz Sperb Wanderley
core