Results 31 to 40 of about 30,994 (308)

Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist.

Cell Metabolism, 2021
Unimolecular triple incretins, combining the activity of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), and glucagon (GCG), have demonstrated reduction in body weight and improved glucose control in rodent models. We
M. Bossart, Michael Wagner, Ralf Elvert, A. Evers, T. Hübschle, Tim Kloeckener, K. Lorenz, Christine Moessinger, O. Eriksson, I. Velikyan, S. Pierrou, Lars Johansson, Gabriele Dietert, Yasmin Dietz-Baum, Thomas Kissner, Irene Nowotny, Christine Einig, Christelle Jan, Faiza Rharbaoui, Johann Gassenhuber, Hans-Peter Prochnow, I. Agueusop, N. Porksen, William B. Smith, A. Nitsche, A. Konkar   +25 more
semanticscholar   +1 more source

Multimodal evaluation of hypoxia in brain metastases of lung cancer and interest of hypoxia image-guided radiotherapy

Scientific Reports, 2021
Lung cancer patients frequently develop brain metastases (BM). Despite aggressive treatment including neurosurgery and external-radiotherapy, overall survival remains poor.
Aurélien Corroyer-Dulmont, Samuel Valable, Jade Fantin, Laurent Chatre, Jérôme Toutain, Sylvain Teulier, Céline Bazille, Elise Letissier, Jérôme Levallet, Didier Divoux, Méziane Ibazizène, Stéphane Guillouet, Cécile Perrio, Louisa Barré, Sébastien Serres, Nicola R. Sibson, Françoise Chapon, Guénaëlle Levallet, Myriam Bernaudin   +18 more
doaj   +1 more source

GIP mediates the incretin effect and glucose tolerance by dual actions on α cells and β cells

Science Advances, 2021
GIPR activity in α cells is required for the complete metabolic response to a meal. Glucose-dependent insulinotropic polypeptide (GIP) communicates nutrient intake from the gut to islets, enabling optimal levels of insulin secretion via the GIP receptor (
K. El, S. Gray, M. Capozzi, E. Knuth, E. Jin, B. Svendsen, A. Clifford, J. Brown, S. Encisco, B. M. Chazotte, K. Sloop, D. J. Nunez, M. Merrins, D. D’Alessio, J. E. Campbell   +14 more
semanticscholar   +1 more source

Innovazione, curricolo flessibile, metodologia attiva per una scuola della durata di 12 anni

Italiano LinguaDue, 2013
documento
GIP scuola Lombardia
doaj   +1 more source

The dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist tirzepatide: a novel cardiometabolic therapeutic prospect

Cardiovascular Diabetology, 2021
Incretin hormones are peptides released in the intestine in response to the presence of nutrients in its lumen. The main incretins are glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
E. Fisman, A. Tenenbaum
semanticscholar   +1 more source

Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists

Molecular Metabolism, 2021
Objective We assessed the spatiotemporal GLP-1 and GIP receptor signaling, trafficking, and recycling dynamics of GIPR mono-agonists, GLP-1R mono-agonists including semaglutide, and GLP-1/GIP dual-agonists MAR709 and tirzepatide.
Aaron Novikoff, S. O’Brien, Miriam Bernecker, Gerald Grandl, M. Kleinert, P. Knerr, K. Stemmer, M. Klingenspor, Anja Zeigerer, R. DiMarchi, M. Tschöp, Brian Finan, D. Calebiro, T. Müller   +13 more
semanticscholar   +1 more source

Dual GIP and GLP-1 Receptor Agonist Tirzepatide Improves Beta-cell Function and Insulin Sensitivity in Type 2 Diabetes

Journal of Clinical Endocrinology and Metabolism, 2020
Context Novel dual glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptor agonist (RA) tirzepatide demonstrated substantially greater glucose control and weight loss (WL) compared with selective GLP-1RA ...
Melissa K Thomas, Amir Nikooienejad, R. Bray, Xuewei Cui, J. Wilson, K. Duffin, Z. Milicevic, A. Haupt, D. Robins   +8 more
semanticscholar   +1 more source

Gastrointestinal Incretins—Glucose-Dependent Insulinotropic Polypeptide (GIP) and Glucagon-like Peptide-1 (GLP-1) beyond Pleiotropic Physiological Effects Are Involved in Pathophysiology of Atherosclerosis and Coronary Artery Disease—State of the Art

Biology, 2022
Simple Summary The presented manuscript contains the most current and extensive summary of the role of the most predominant gastrointestinal hormones—GIP and GLP-1 in the pathophysiology of atherosclerosis and coronary artery disease both in animals and ...
Szymon Jonik, M. Marchel, M. Grabowski, G. Opolski, T. Mazurek   +4 more
semanticscholar   +1 more source

Establishment of novel specific assay for short‐form glucose‐dependent insulinotropic polypeptide and evaluation of its secretion in nondiabetic subjects

Physiological Reports, 2020
The short‐form glucose‐dependent insulinotropic polypeptide (GIP) (1–30) is released from islet alpha cells and promotes insulin secretion in a paracrine manner in vitro. However, it is not well elucidated how GIP (1–30) is involved in glucose metabolism
Yasutaka Takeda, Yukihiro Fujita, Tsuyoshi Yanagimachi, Nobuhiro Maruyama, Ryoichi Bessho, Hidemitsu Sakagami, Jun Honjo, Hiroki Yokoyama, Masakazu Haneda   +8 more
doaj   +1 more source

The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials

Diabetes Therapy, 2020
Glucagon-like peptide 1 (GLP-1) based therapy is an established treatment option for the management of type 2 diabetes mellitus (T2DM) and is recommended early in the treatment algorithm owing to glycaemic efficacy, weight reduction and favourable ...
T. Min, S. Bain
semanticscholar   +1 more source