Results 31 to 40 of about 74,465 (332)

Glucose-Dependent Insulinotropic Polypeptide (GIP) Induces Calcitonin Gene-Related Peptide (CGRP)-I and Procalcitonin (Pro-CT) Production in Human Adipocytes [PDF]

open access: yes, 2011
Context: Increased plasma levels of glucose-dependent insulinotropic polypeptide (GIP), calcitonin CT gene-related peptide (CGRP)-I, and procalcitonin (Pro-CT) are associated with obesity.
Christ-Crain, Mirjam   +10 more
core   +1 more source

Establishment of novel specific assay for short‐form glucose‐dependent insulinotropic polypeptide and evaluation of its secretion in nondiabetic subjects

open access: yesPhysiological Reports, 2020
The short‐form glucose‐dependent insulinotropic polypeptide (GIP) (1–30) is released from islet alpha cells and promotes insulin secretion in a paracrine manner in vitro. However, it is not well elucidated how GIP (1–30) is involved in glucose metabolism
Yasutaka Takeda   +8 more
doaj   +1 more source

A Good Idea is Not Enough: Understanding the Challenges of Entrepreneurship Communication [PDF]

open access: yes, 2016
This paper addresses a less-investigated issue of innovations: entrepreneurship communication. Business and marketing studies demonstrate that new product development processes do not succeed on good technical invention alone.
Jakobs, Eva-Maria   +2 more
core   +1 more source

The Role of Tirzepatide, Dual GIP and GLP-1 Receptor Agonist, in the Management of Type 2 Diabetes: The SURPASS Clinical Trials

open access: yesDiabetes Therapy, 2020
Glucagon-like peptide 1 (GLP-1) based therapy is an established treatment option for the management of type 2 diabetes mellitus (T2DM) and is recommended early in the treatment algorithm owing to glycaemic efficacy, weight reduction and favourable ...
T. Min, S. Bain
semanticscholar   +1 more source

The Role of GIP Receptor in the CNS for the Pathogenesis of Obesity

open access: yesDiabetes, 2021
Glucose-dependent insulinotropic polypeptide (GIP) (also known as gastric inhibitory polypeptide) is a hormone produced in the upper gut and secreted to the circulation in response to the ingestion of foods, especially fatty foods.
M. Fukuda
semanticscholar   +1 more source

Potential of using polyethylene as viscosity enhancer of palm oil to use as a lubricating oil

open access: yesAdvances in Mechanical Engineering, 2020
Biodegradable vegetable oil-based lubricating oil is a better auxiliary for mineral-based lubricants as their viscosity index, flash point, lubricity is high.
TKKS Pathmasiri, GIP Perera
doaj   +1 more source

Glucose-Dependent Insulinotropic Polypeptide Suppresses Foam Cell Formation of Macrophages through Inhibition of the Cyclin-Dependent Kinase 5-CD36 Pathway

open access: yesBiomedicines, 2021
Glucose-dependent insulinotropic polypeptide (GIP) has been reported to have an atheroprotective property in animal models. However, the effect of GIP on macrophage foam cell formation, a crucial step of atherosclerosis, remains largely unknown.
Michishige Terasaki   +11 more
doaj   +1 more source

The Role of GIP in the Regulation of GLP-1 Satiety and Nausea

open access: yesDiabetes, 2021
Gastric inhibitory peptide (GIP) is best known for its role as an incretin hormone in control of blood glucose concentrations. As a classic satiation signal, however, the literature illustrates a mixed picture of GIP involvement with an at best weak ...
M. R. Hayes, T. Borner, B. D. De Jonghe
semanticscholar   +1 more source

LY3298176, a novel dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes mellitus: From discovery to clinical proof of concept

open access: yesMolecular Metabolism, 2018
Objective A novel dual GIP and GLP-1 receptor agonist, LY3298176, was developed to determine whether the metabolic action of GIP adds to the established clinical benefits of selective GLP-1 receptor agonists in type 2 diabetes mellitus (T2DM).
T. Coskun   +15 more
semanticscholar   +1 more source

GIP as a Therapeutic Target in Diabetes and Obesity: Insight From Incretin Co-agonists

open access: yesJournal of Clinical Endocrinology and Metabolism, 2020
The 2 hormones responsible for the amplification of insulin secretion after oral as opposed to intravenous nutrient administration are the gut peptides, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP).
J. Holst, M. Rosenkilde
semanticscholar   +1 more source

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