Results 31 to 40 of about 27,755 (279)

GIP(3-30)NH2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release [PDF]

, 2017
Alternative processing of the precursor protein pro-GIP results in endogenously produced GIP(1-30)NH2, that by DPP-4 cleavage in vivo results in the metabolite GIP(3-30)NH2.
B Hartmann, Gasbjerg, L S, Svendsen, B, Rosenkilde, M M, L.S. Gasbjerg, M.N. Gabe, Hartmann, B, J.J. Holst, Gabe, M N, M.M. Rosenkilde, Sparre-Ulrich, A H, B. Svendsen, Holst, J J, C.B. Christiansen, A.H. Sparre-Ulrich, Christiansen, C B   +15 more
core   +1 more source

The naturally occurring GIP(1-30)NH₂ is a GIP receptor agonist in humans

, 2023
OBJECTIVE: The gut hormone glucose-dependent insulinotropic polypeptide (GIP) is an important regulator of glucose and bone metabolism. In rodents, the naturally occurring GIP variant, GIP(1-30)NH2, has shown similar effects as full-length GIP (GIP(1-42))
Hartmann, Bolette, Bergmann, Natasha C, Joachim Størling, Natasha C Bergmann, Holst, Jens J, Bolette Hartmann, Jens J Holst, Signe Stensen, Lærke S Gasbjerg, Krogh, Liva S L, Kristine Henriksen, Kirsa Skov-Jeppesen, Henriksen, Kristine, Rosenkilde, Mette M, Gasbjerg, Lærke S, Stensen, Signe, Knop, Filip K, Filip K Knop, Størling, Joachim, Skov-Jeppesen, Kirsa, Liva S L Krogh, Mette M Rosenkilde   +21 more
core   +1 more source

Designing a Dual GLP-1R/GIPR Agonist from Tirzepatide: Comparing Residues Between Tirzepatide, GLP-1, and GIP

Drug Design, Development and Therapy, 2022
Lijing Wang College of Life Sciences and Technology, China Pharmaceutical University, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Lijing Wang, College of Life Science and Technology, China Pharmaceutical University, 639 Longmian ...
Wang L
doaj  

EAT-GIP data.sav

, 2023
EAT ...
Zhen Chen (16984878)
core   +1 more source

Cross-sectional and longitudinal characterization of SCD patients recruited from the community versus from a memory clinic: subjective cognitive decline, psychoaffective factors, cognitive performances, and atrophy progression over time

Alzheimer’s Research & Therapy, 2019
Background Subjective cognitive decline (SCD) defines a heterogeneous population, part of which having Alzheimer’s disease (AD). We aimed at characterizing SCD populations according to whether or not they referred to a memory clinic, by assessing the ...
Elizabeth Kuhn, Inès Moulinet, Audrey Perrotin, Renaud La Joie, Brigitte Landeau, Clémence Tomadesso, Alexandre Bejanin, Siya Sherif, Vincent De La Sayette, Béatrice Desgranges, Denis Vivien, Géraldine Poisnel, Gaëlle Chételat   +12 more
doaj   +1 more source

GIP-1 is required for a subset of dynamic microtubules at the apical ncMTOC.

, 2018
(A) Projected 1.5 μm optical sections through the E16 intestinal primordium show EBP-2/EB1::GFP localization in live bean-stage embryos of indicated genotypes.
Taylor D. Skokan (5597939), Jessica L. Feldman (175808), Maria D. Sallee (5597933), Brian C. Raftrey (5597942), Jennifer C. Zonka (5597936)   +4 more
core   +1 more source

The first generic tirzepatide GP30931: physicochemical and biological similarity to the reference drug

Разработка и регистрация лекарственных средств
Introduction. Metabolic syndrome is a multifactorial complex of metabolic disorders accompanied by type 2 diabetes mellitus and abdominal obesity.
I. A. Lugovik, A. V. Babina, S. S. Arutyunyan, D. О. Ermolaeva, V. B. Saparova, T. N. Kobeleva, P. G. Zaikin, A. D. Mikushina, A. S. Bukatin, I. E. Eliseev, B. Ts. Zajchik, Y. S. Keruchenko, I. S. Ohrimenko, E. V. Bocharov, A. Kh. Taldaev, V. A. Lushpa, I. E. Makarenko, R. V. Drai   +17 more
doaj   +1 more source

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Brain and cognitive correlates of sleep fragmentation in elderly subjects with and without cognitive deficits

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2019
Introduction Sleep disturbances are increasingly recognized as a risk factor for Alzheimer's disease. However, no study has assessed the relationships between objective sleep fragmentation (SF) and brain and cognitive integrity across different cognitive
Claire André, Clémence Tomadesso, Robin deFlores, Pierre Branger, Stéphane Rehel, Florence Mézenge, Brigitte Landeau, Vincent de laSayette, Francis Eustache, Gaël Chételat, Géraldine Rauchs   +10 more
doaj   +1 more source

The Spatiotemporal Genetic Architecture of Seed Vigor in Upland Cotton

Advanced Science, EarlyView.
Leveraging the semi‐automated SeedRanger platform, we profiled the germination kinetics of 356 cotton accessions at a 30‐min interval. This high‐throughput phenomic approach delineated a temporal genetic network comprising 541 stage‐specific loci. Crucially, functional validation identified FLA2 as a pivotal, auxin‐modulated regulator that orchestrates
Luyao Wang, Jie Dai, Ting Zhao, Shengjun Zhao, Hongyu Wu, Jiaying Pan, Yupeng Hao, Ke Nie, Li Yu, Yumeng Zhu, Xiangyi Zhao, Kai Huang, Mengke Zhang, Yongyan Zhao, Yaping Jiang, Siyuan Wang, Yiling Pan, Yubing Chen, Yilai Lin, Wanghong Shi, Yayuan Deng, Jin Han, Jie Li, Xuan Long, Junbin Wang, Zhiyuan Zhang, Zegang Han, Zhanfeng Si, Lei Ju, Jun Li, Tianzhen Zhang, Ji Zhou, Xueying Guan   +32 more
wiley   +1 more source