Results 31 to 40 of about 148,838 (258)

Development and optimization of the Glabridin-loaded dissolving microneedle for enhanced treatment of keloid

International Journal of Pharmaceutics: X
Glabridin (Gla) has been reported to have significant effects in scar treatment, and however, the water insolubility of Gla leads to its poor transdermal absorption ability, which affects its bioactivities.
Juan Guo, Zhongtang Chen, Rong Huang, Dandan Tang, Yuhuan Wang, Pan Song, Liangyu Mei, Shuguang Hou, Wei Peng, Lisha He, Qiang Ren   +10 more
doaj   +1 more source

Deconjugation Kinetics of Glucuronidated Phase II Flavonoid Metabolites by B-glucuronidase from Neutrophils [PDF]

, 2010
Flavonoids are inactivated by phase II metabolism and occur in the body as glucuronides. Mammalian ß-glucuronidase released from neutrophils at inflammatory sites may be able to deconjugate and thus activate flavonoid glucuronides.
Arts, I.C.W., Bartholomé, R., Bast, A., Dagnelie, P.C., Haenen, G., Hollman, P.C.H., Keijer, J., Kroon, P.A., Needs, P.W., Roos, D.   +9 more
core   +2 more sources

Glaucocalyxin A inhibits platelet activation and thrombus formation preferentially via GPVI signaling pathway. [PDF]

PLoS ONE, 2013
Platelets play a pivotal role in atherothrombosis and the antiplatelet agents have been proved to be useful in preventing onset of acute clinical events including myocardial infarction and stroke.
Wei Li, Xiaorong Tang, Wenxiu Yi, Qiang Li, Lijie Ren, Xiaohui Liu, Chunjun Chu, Yukio Ozaki, Jian Zhang, Li Zhu   +9 more
doaj   +1 more source

Long-Run Accuracy of Variational Integrators in the Stochastic Context [PDF]

, 2010
This paper presents a Lie-Trotter splitting for inertial Langevin equations (Geometric Langevin Algorithm) and analyzes its long-time statistical properties. The splitting is defined as a composition of a variational integrator with an Ornstein-Uhlenbeck
Bou-Rabee N., Houman Owhadi, Nawaf Bou-Rabee, Talay D.   +3 more
core   +3 more sources

Association of Corticospinal Tract Asymmetry With Ambulatory Ability After Intracerebral Hemorrhage

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ambulatory ability after intracerebral hemorrhage (ICH) is important to patients. We tested whether asymmetry between ipsi‐ and contra‐lesional corticospinal tracts (CSTs) assessed by diffusion tensor imaging (DTI) is associated with post‐ICH ambulation.
Yasmin N. Aziz, Carl D. Langefeld, Mary E. Comeau, Miranda C. Marion, Tyler P. Behymer, Lee A. Gilkerson, Padmini Sekar, Weihong Yuan, Vivek Khandwala, Brady J. Williamson, Thomas Maloney, Achala Vagal, Pierce Boyne, Kari Dunning, Matthew L. Flaherty, Steven J. Kittner, Prachi Mehndiratta, Gunjan Y. Parikh, Michael L. James, David Roh, Fernando D. Testai, Farhaan S. Vahidy, James Thornton, Ranjit Bagga, Daniel Woo, Stacie L. Demel   +25 more
wiley   +1 more source

Conversion from insulin glargine U-100 to insulin glargine U-300 or insulin degludec and the impact on dosage requirements

Therapeutic Advances in Endocrinology and Metabolism, 2018
Background: We wanted to determine whether basal insulin requirements change when patients transition from insulin glargine U-100 (Gla-100) to insulin glargine U-300 (Gla-300) or insulin degludec.
Scott M. Pearson, Jennifer M. Trujillo
doaj   +1 more source

On Free Pseudo-Product Fundamental Graded Lie Algebras [PDF]

, 2012
In this paper we first state the classification of the prolongations of complex free fundamental graded Lie algebras. Next we introduce the notion of free pseudo-product fundamental graded Lie algebras and study the prolongations of complex free pseudo ...
Yatsui, Tomoaki
core   +4 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Encapsulation nanoarchitectonics of glabridin with sophorolipid micelles for addressing biofilm hazards via extracellular polymeric substance permeation and srtA gene suppression

Ecotoxicology and Environmental Safety
Background: Biofilm, a common drug-resistant phenotype of Staphylococcus aureus (S. aureus), demonstrates significant drug resistance and recurrence due to its extracellular polymeric substance (EPS) barrier and subsequent bacterial migration.
Shiyu Lin, Xiaojuan Li, Wei Zhang, Gang Shu, Haohuan Li, Funeng Xu, Juchun Lin, Guangneng Peng, Li Zhang, Hualin Fu   +9 more
doaj   +1 more source

A Descriptive Analysis of the Retail Real Estate Markets at the Metropolitan Level [PDF]

, 1997
Gross Leasable Area (GLA) per capita is a commonly used measure to compare the retail market potential across different retail real estate markets. This study uses GLA per capita to assess the supply of the retail space across fifty-eight metropolitan ...
Eppli, Mark, Laposa, Steven P.
core   +1 more source