Results 21 to 30 of about 2,632 (194)

Correction: Estrogenicity of Glabridin in Ishikawa Cells. [PDF]

PLoS ONE, 2015
The following information is missing from the Funding section: This work was supported by Taylor's University through its Postgraduate Research Scholarship Programme to MSWP. The complete, correct funding information is as follows: This work was supported by Exploratory Research Grants Scheme ERGS/1/2012/STG08/TAYLOR/03/2) to YYC, and Fundamental ...
Melissa Su Wei Poh, Phelim Voon Chen Yong, Navaratnam Viseswaran, Yoke Yin Chia   +3 more
doaj   +3 more sources

Glabridin-Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity. [PDF]

Adv Sci (Weinh)
Complex 6d could promote tumor immunogenicity by targeting thioredoxin reductase (TrxR) and remodel immunosuppressive microenvironment by the mitogen‐activated protein kinase (MAPK) pathway inhibition simultaneously. This study provides a novel approach to develop metal immunomodulatory agents by designing gold complexes incorporating natural products,
Wang Z, Wang M, Chen Q, Wang M, Li F, Lv L, Wen Z, Xu Z, Yang Y, Bi C, Liu W.   +10 more
europepmc   +2 more sources

Factors Influencing Glabridin Stability [PDF]

Natural Product Communications, 2010
Glabridin, a polyphenolic isoflavan of Glycyrrhiza glabra, has shown a variety of pharmaceutical properties. We have previously studied the isolation of glabridin using macroporous resin and found that it is partially degraded, giving a dark color. To illustrate the degradation of glabridin, the present work studied the stability of glabridin under ...
Mingzhang, Ao, Yue, Shi, Yongming, Cui, Wentao, Guo, Jing, Wang, Longjiang, Yu   +5 more
openaire   +2 more sources

Glabridin mediate caspases activation and induces apoptosis through JNK1/2 and p38 MAPK pathway in human promyelocytic leukemia cells. [PDF]

PLoS ONE, 2014
BACKGROUND: Glabridin, a prenylated isoflavonoid of G. glabra L. roots, has been associated with a wide range of biological properties such as regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, and skin-whitening in previous
Hsin-Lien Huang, Ming-Ju Hsieh, Ming-Hsien Chien, Hui-Yu Chen, Shun-Fa Yang, Pei-Ching Hsiao   +5 more
doaj   +1 more source

The mechanisms of melanogenesis inhibition by glabridin: molecular docking, PKA/MITF and MAPK/MITF pathways

Food Science and Human Wellness, 2023
Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins. However, the underlying mechanism(s) remain not completely understood.
Chunxing Pan, Xiaoying Liu, Yating Zheng, Zejun Zhang, Yongliang Li, Biao Che, Guangrong Liu, Lanyue Zhang, Changzhi Dong, Haji Akber Aisa, Zhiyun Du, Zhengqiang Yuan   +11 more
doaj   +1 more source

Discovery of a Novel Cyclopeptide as Tyrosinase Inhibitor for Skin Lightening. [PDF]

Skin Res Technol
ABSTRACT Background Melanin synthesis plays a crucial role in skin pigmentation, and inhibiting tyrosinase, the key enzyme in melanin production, is a primary strategy for developing skin‐lightening agents. This study investigates the tyrosinase inhibitory potential of CHP‐9, a novel cyclopeptide, and evaluates its cytotoxicity and efficacy as a ...
Chang H, Tao K, Huang H, Jia J, Khan SN, Cui J.   +5 more
europepmc   +2 more sources

Phytochemistry and biological properties of glabridin [PDF]

Fitoterapia, 2013
Glabridin, a prenylated isoflavonoid of G. glabra L. roots (European licorice, Fabaceae), has been associated with a wide range of biological properties such as antioxidant, anti-inflammatory, anti-atherogenic, regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, and skin-whitening. While glabridin is one of the most studied
Charlotte, Simmler, Guido F, Pauli, Shao-Nong, Chen   +2 more
openaire   +2 more sources

Total Synthesis of (±)-Glabridin [PDF]

Synthetic Communications, 2013
An efficient formal synthesis of (±)-glabridin was accomplished in 10 steps from resorcinol using Raney Ni to reduce carbon–carbon double bonds in α,β-unsaturated carbonyl compound as the key step. [Supplementary materials are available for this article.
Ji, Wen-Hua, Gao, Qian-Shan, Lin, Yun-Liang, Gao, Hong-Mei, Wang, Xiao, Geng, Yan-Ling   +5 more
openaire   +1 more source

Mechanisms of glabridin inhibition of integrin αIIbβ3 inside-out signals and NF-κB activation in human platelets

Chinese Medicine, 2023
Background Platelets play a crucial role in cardiovascular diseases (CVDs) and are activated by endogenous agonists like collagen. These agonists initiate signal transduction through specific platelet receptors, resulting in platelet aggregation ...
Wei-Chieh Huang, Thanasekaran Jayakumar, Joen-Rong Sheu, Chih-Wei Hsia, Chih-Hsuan Hsia, Ting-Lin Yen, Chao-Chien Chang   +6 more
doaj   +1 more source

Glabridin induces paraptosis-like cell death via ER stress in breast cancer cells

Heliyon, 2022
Glabridin, a polyphenolic flavonoid isolated from the root of the glycyrrhiza glabra, has been demonstrated to have anti-tumor properties in human malignancies. This study found that glabridin decreased the viability of human breast cancer MDA-MB-231 and
Xiang Cui, Min Cui
doaj   +1 more source