Results 51 to 60 of about 2,770 (195)

Glabridin‐Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity

Advancement of science
Metal‐based drugs have been utilized as immunomodulatory agents in combination with cancer immunotherapies to induce tumor immunogenicity. However, the immunosuppressive tumor microenvironment significantly hinders the efficacy of these immunomodulatory ...
Zhao-Ran Wang, Mei-Yu Wang, Qiong Chen, Meng-Shi Wang, Fuwei Li, Lin Lv, Zhen-Fan Wen, Zhong-Ren Xu, Yi-Xia Yang, Chun-Yang Bi, Wu-Kun Liu   +10 more
semanticscholar   +1 more source

Cellular Responses and Targets in Food Spoilage Yeasts Exposed to Antifungal Prenylated Isoflavonoids

Microbiology Spectrum, 2023
Prenylated isoflavonoids are phytochemicals with promising antifungal properties. Recently, it was shown that glabridin and wighteone disrupted the plasma membrane (PM) of the food spoilage yeast Zygosaccharomyces parabailii in distinct ways, which led ...
Sylvia Kalli, Cindy Vallieres, Joseph Violet, Jan-Willem Sanders, John Chapman, Jean-Paul Vincken, Simon V. Avery, Carla Araya-Cloutier   +7 more
doaj   +1 more source

Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients

Cosmetics, 2022
The interest in plant extracts and natural compounds in cosmetic formulations is growing. Natural products may significantly improve cosmetics performance since they have both cosmetic and therapeutic-like properties, known as cosmeceutical effects ...
Antonietta Cerulli, Milena Masullo, Paola Montoro, Sonia Piacente   +3 more
doaj   +1 more source

Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways

Molecular Medicine, 2022
Background Glabridin (Glab) is a bioactive component of licorice that can ameliorate diabetes, but its role in diabetic nephropathy (DN) has seldom been reported. Herein, we explored the effect and underlying mechanism of Glab on DN.
Hongtao Tan, Junxian Chen, Yi-Cong Li, Ying-Shan Li, Yunchang Zhong, Guangzhao Li, Lingling Liu, Yi-Qun Li   +7 more
semanticscholar   +1 more source

Inhibition of bone marrow-derived dendritic cell maturation by glabridin

, 2010
Glabridin has multiple pharmacological activities including anti-microbial, anti-atherosclerotic, anti-nephritic, anti-inflammatory and cardiovascular protective activities. In this study, we investigated the effect of glabridin on dendritic cells, which
Jong Soon Kang, Jee Youn Kim, Hwan Mook Kim, J Y Kim, Yeon Jin Kim, H K Lee, H S Ryu, Youngsoo Kim, Hong Kyung Lee, H S Kim, Jin Tae Hong, J T Hong, Sang-Bae Han, Y J Kim, Hyung Sook Kim, S B Han, Y Kim, Hwa Sun Ryu   +17 more
core   +1 more source

Glabridin-encapsulated liposomes targeting melanocytes through the melanocortin 1 receptor.

Colloids and Surfaces B: Biointerfaces
Glabridin, a potent skin-whitening agent extracted from Glycyrrhiza glabra L., shows immense therapeutic potential. However, its application is hindered by its poor water solubility and limited ability to penetrate the stratum corneum.
Lushi Cheng, Junying Xu, Anning Wang, Sen Hou, An-Zhang Li   +4 more
semanticscholar   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Glabridin, a Bioactive Flavonoid from Licorice, Effectively Inhibits Platelet Activation in Humans and Mice

, 2022
Platelets are crucial for hemostasis and arterial thrombosis, which may lead to severe cardiovascular diseases (CVDs). Thus, therapeutic agents must be developed to prevent pathological platelet activation.
Chen, Jui-Hsuan, Joen-Rong Sheu, Hsia, Chih-Wei, Jayakumar, Thanasekaran, Sheu, Joen-Rong, Chung, Chi-Li, Wei-Chieh Huang, Jui-Hsuan Chen, Kuan-Rau Chiou, Hsia, Chih-Hsuan, Chiou, Kuan-Rau, Hou, Shaw-Min, Huang, Wei-Chieh, Thanasekaran Jayakumar, Shaw-Min Hou, Chih-Hsuan Hsia, Chi-Li Chung, Chih-Wei Hsia   +17 more
core   +1 more source

Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra

, 2007
Purpose. Glabridin is a major active constituent of Glycyrrhiza glabra which is commonly used in the treatment of cardiovascular and central nervous system (CNS) diseases. Recently, we have found that glabridin is a substrate of P-glycoprotein (PgP/MDR1).
Li, XT, Chowbay, B., Yu, Xueqing, Zhou, ZW, Zhou, Zhi-Wei, Wen, J.-Y., Li, X.-T., Li, C.-G., Chen, X., Chan, Eli, Chen, X, Yu, XQ, Xue, C.C., Lin, SG, Liang, J, Xue, CC, Yu, X.-Y., Li, Xiaotian, Yu, XY, Chowbay, Balram, Chowbay, B, Zhou, SF, Cao, J, Chan, E, Duan, W, Lin, S.-G., Zhou, Z.-W., Yu, Xiyong, Liang, J., Li, Chun Guang (R17249), Chen, Xiao, Yu, X.-Q., Xue, Charlie C. L., Duan, Wei, Liang, Jun, Chan, E., Cao, J., Cao, Jie, Zhou, S.-F., Zhou, Shu-Feng, Lin, Shuguang, Duan, W., Li, CG, Wen, Jingyuan   +43 more
core   +3 more sources

Ischemic Stroke and Traumatic Brain Injury: Epidemiology, Molecular Pathways, and Emerging Therapies

MedComm, Volume 7, Issue 10, October 2026.
Schematic overview of secondary brain injury after ischemic stroke and traumatic brain injury. Both conditions trigger endothelial cell dysfunction, pericyte contraction, and upregulated AQP4 expression in astrocytic end‐feet, leading to blood–brain barrier disruption.
Mengzhao Feng, Qi Qin, Fang Wang, Kaiyuan Zhang, Zhihua Li, Junlei Chang, Min Yu, Fuyou Guo   +7 more
wiley   +1 more source