Results 71 to 80 of about 2,632 (194)

Coordinate regulation of antimycin and candicidin biosynthesis [PDF]

, 2016
Streptomyces species produce an incredible array of high-value specialty chemicals and medicinal therapeutics. A single species typically harbors ~30 biosynthetic pathways, but only a mere handful of them are expressed in the laboratory, thus poor ...
Alexander, Antón, Bailey, Barke, Bentley, Bibb, Bush, Carmody, Chen, Cheng, CLSI, Cobb, Crooks, Di Rago, Dunshee, Fernández-Martínez, Finlayson, Fu, Fuqua, Gil, Gomez-Escribano, Gust, Kieser, Langmead, Li, Liu, Liu, Liu, Mattia, Newman, Olano, Pérez-Llarena, Ramírez, Robinson, Rudolph, Sandy, Sandy, Santamarta, Santos-Aberturas, Schoenian, Schoenian, Seipke, Seipke, Seipke, Seipke, Seipke, Seipke, Sekurova, Shao, Sit, Tappel, Taylor, Tzung, van Wezel, Vicente, Vincent, Ward, Yan, Yan, Yanai, Zhang   +60 more
core   +3 more sources

Bioinformatics analyses on molecular pathways and pharmacological properties of Glabridin

International Journal of Agriculture Environment and Food Sciences, 2021
Glabridin, a bioactive compound that originally isolated from the roots of licorice (Glycyrrhiza glabra L., Fam. Fabaceae), has a wide range of pharmacological properties for instance anti-inflammatory, anti-cancer, anti-microbial, anti-viral, anti-osteoporosis, anti-diabetic, anti-atherogenic, neuroprotective, estrogenic, and skin-whitening.
Sevgi GEZİCİ, Nazım ŞEKEROĞLU
openaire   +3 more sources

Glabridin Attenuates the Retinal Degeneration Induced by Sodium Iodate In Vitro and In Vivo

Frontiers in Pharmacology, 2020
BackgroundAge-related macular degeneration (AMD) is one of the major causes of blindness in the elderly over the age of 60. AMD is divided into dry AMD and wet AMD.
Kaung Htet Aung, Kaung Htet Aung, Hua Liu, Zongwen Ke, Shuang Jiang, Jianhua Huang   +5 more
doaj   +1 more source

Role of glabridin in maintaining residual kidney function in dialysis patients [PDF]

, 2017
Purpose: To demonstrate the effect of glabridin on peritoneal function and residual renal function (RRF) in peritoneal dialysis (PD) patients.Methods: Twenty five patients (age range, 24 - 58 years) with a glomerular filtration rate of above 2 mL/min/1 ...
Liu, Yun-Qi, Zhang, Wei-Qun
core   +2 more sources

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, Volume 58, Issue 10, October 2025.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Glabridin-induced vasorelaxation: Evidence for a role of BK_Ca channels and cyclic GMP [PDF]

, 2016
Background and purposeGlabridin is a major flavonoid in Glycyrrhiza glabra (licorice) root, a traditional Asian medicine. Glabridin is reported to have anti-atherogenic, anti-inflammatory and anti-nephritic properties; however its effects on vascular ...
Aaronson, Philip I, Chanda, Debrabata, Iqbal, Hina, Prieto-Lloret, Jesus, Singh, Arjun, Snetkov, Vladimir, Yadav, Pankaj   +6 more
core   +1 more source

Absolute Configurations of (±)-Glabridin Enantiomers

Bulletin of the Korean Chemical Society, 2009
Concerned with ambiguous stereochemistry assignment of natural (+)-glabridin, absolute configurations of (±)glabridin enantiomers were studied with synthetic glabridin. Synthetic glabridin enantiomers were separated by semi-preparative Sumi-chiral column chromatography, and characterized by UV-Vis and NMR spectroscopy.
openaire   +2 more sources

Flavonoids as Promising Akt1 Inhibitors in Cancer Medicine: Insights From Molecular Docking, Dynamics, DFT Calculations, and In Vitro Validation

Cancer Reports, Volume 8, Issue 8, August 2025.
ABSTRACT Background The PI3K/Akt/mTOR signaling pathway is commonly deregulated in different types of cancers, contributing to tumor proliferation, persistence, and resistance to treatment. Akt1, a crucial kinase within this pathway, plays a critical role in tumor progression and the occurrence of therapeutic resistance.
Shokoofeh Jamshidi, Ali Eghbalian, Setareh Shojaei, Amir Taherkhani, Mehran Feizi‐Dehnayebi   +4 more
wiley   +1 more source

Phytoestrogens [PDF]

, 2004
Collectively, plants contain several different families of natural products among which are compounds with weak estrogenic or antiestrogenic activity toward mammals.
Adlercreutz H, Alekel DL, Bhathena SJ, Bielenberg J, Biendl M, Boller B, Dai Q, Day JK, de Kleijn MJJ, den Tonkelaar I, denTonkelaar I, Dewick PM, Ebisawa H, Fritz WA, Guo TL, Hodgson JM, Horn-Ross PL, ILDIS, Kim CS, Lamartiniere CA, Maggiolini M, Maskarinec G, McCann SE, Mentor MR, MerzDemlow BE, Newbold RR, Pan W, Peluso MR, Richard A. Dixon, Seested S, Setchell KDR, Setchell KDR, Setchell KDR, Slavin JL, Stevens JF, Whitten PL, Yanagihara K, Zhang Y   +37 more
core   +1 more source

Centaurea lycaonica Extracts Induce Apoptosis in HeLa Human Cervical Cancer Cells via Bax/Bcl‐2 Modulation and Caspase Activation: An LC‐HRMS‐Based Study

Food Science &Nutrition, Volume 13, Issue 7, July 2025.
This study highlights the pharmacological mechanisms of dichloromethane (CHD) and methanol (CHM) extracts of Centaurea lycaonica Boiss. & Heldr. herba as the induction of apoptosis on HeLa cells. Apoptotic properties of CHD and CHM are through suppression of Bcl‐2 and increase in Bax, caspase 9, and 3 activities on HeLa cells.
Ayşe Kübra Karaboğa Arslan, Safa Eminoğlu, Leyla Paşayeva, Nuh Mehmet Bozkurt, Osman Tugay   +4 more
wiley   +1 more source