Diabetes, Obesity and Metabolism, EarlyView.Abstract Aims Diabetic ketoacidosis (DKA) is a serious complication of diabetes, requiring intravenous (IV) insulin until resolution and subsequent transition to subcutaneous insulin. Currently, clinical guidelines vary regarding the timing of long‐acting subcutaneous insulin initiation, with some advocating early administration during IV insulin ...
Bachviet Nguyen +4 more
wiley +1 more source
The economic prognosis of the new analog of insulin glargine usage in diabetes mellitus type 2
Качественная клиническая практика, 2018 Modelling has been performed for evaluation of economic perspectives of new insulin glargine 300 IU/ml usage for diabetes mellitus type 2 (DM2) control based on literature analysis of non-direct comparison with insulin detemir.
D. Yu. Belousov, E. V. Afanasyeva
doaj
Insulin glargine affects the expression of Igf-1r, Insr, and Igf-1 genes in colon and liver of diabetic rats [PDF]
Iranian Journal of Basic Medical Sciences, 2018 Objective(s): The mitogenic effect of the analogous insulin glargine is currently under debate since several clinical studies have raised the possibility that insulin glargine treatment has a carcinogenic potential in different tissues.
Clara I Juárez-Vázquez +8 more
doaj +1 more source
Once-Weekly Exenatide Versus Once- or Twice-Daily Insulin Detemir: Randomized, open-label, clinical trial of efficacy and safety in patients with type 2 diabetes treated with metformin alone or in combination with sulfonylureas [PDF]
, 2013 OBJECTIVEdThis multicenter, open-label, parallel-arm study compared the efficacy and safety of exenatide once weekly (EQW) with titrated insulin detemir in patients with type 2 diabetes inadequately controlled with metformin (with or without ...
Adetunji, O. +6 more
core +1 more source
Obesity Reviews, EarlyView.ABSTRACT Introduction Glucagon‐like peptide‐1 receptor agonists (GLP‐1 RA) improve outcomes in heart failure (HF) with preserved ejection fraction. Whether GLP‐1 RA prevent new‐onset HF in Type 2 diabetes or obesity requires further investigation. Methods We performed an updated meta‐analysis of randomized placebo‐controlled trials (RCT) of treatment ...
João Sérgio Neves +8 more
wiley +1 more source
Prevention of tumour cell apoptosis associated with sustained protein kinase B phosphorylation is more sensitive to regulation by insulin signalling than stimulation of proliferation and extracellular signal-regulated kinase [PDF]
, 2017 Insulin controls blood glucose while insulin-like growth factor (IGF) 1 is an important growth factor. Interestingly, both hormones have overlapping bioactivities and can activate the same intracellular signal transduction cascades.
Christoph Schmid +2 more
core +2 more sources
Strategies to Improve the Lipophilicity of Hydrophilic Macromolecular Drugs
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.Hydrophilic macromolecular drugs can be successfully lipidized by covalent attachment of lipids, by hydrophobic ion pairing with negatively or positively charged surfactants, and by dry or wet reverse micelle formation. Lipophilicity enhancement of hydrophilic macromolecules has several benefits including stability and bioavailability improvement ...
Sera Lindner +8 more
wiley +1 more source
Are Glucose Readings Sufficient to Adjust Insulin Dosage? [PDF]
, 2011 Aims/hypothesis: Insulin therapy is effective predominantly when dosage is frequently adjusted. However, a controversy surrounds the pertinent clinical parameters required to make effective and safe frequent dosage adjustments.
Bashan, Eran +2 more
core +1 more source
Managing feline diabetes: current perspectives [PDF]
, 2018 Diabetes mellitus is a common endocrine disease in cats. While type 2 diabetes is the most common form seen in cats, other underlying causes may contribute to insulin resistance.
Gottlieb, Susan, Rand, Jacquie
core +1 more source