Results 131 to 140 of about 160,715 (360)

CSF Monoamine Metabolites and Cognitive Trajectory in Early Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Imaging and postmortem studies indicate that abnormalities in monoaminergic neurotransmission contribute to cognitive impairment in Parkinson's disease (PD). However, it remains uncertain if cerebrospinal fluid (CSF) monoamine metabolites can serve as biomarkers of cognitive decline in early PD.
Jing‐Yu Shao, Rong Li, Yu‐Xiang Jiao, Kai Ma, Hong‐Qi Yang, Zheng‐Yu Sun, Jie‐Wen Zhang, Shuai Chen   +7 more
wiley   +1 more source

Microglia modulate the cerebrovascular reactivity through ectonucleotidase CD39

Nature Communications
Microglia and the border-associated macrophages contribute to the modulation of cerebral blood flow, but the mechanisms have remained uncertain.
Zhongxiao Fu, Mallikarjunarao Ganesana, Philip Hwang, Xiao Tan, Melissa Marie Kinkaid, Yu-Yo Sun, Emily Bian, Aden Weybright, Hong-Ru Chen, Katia Sol-Church, Ukpong B. Eyo, Clare Pridans, Francisco J. Quintana, Simon C. Robson, Pankaj Kumar, B. Jill Venton, Anne Schaefer, Chia-Yi Kuan   +17 more
doaj   +1 more source

Chemogenetic Schwann cell activation impairs early myelination and triggers adult demyelination in the peripheral nervous system

Frontiers in Cellular Neuroscience
Schwann cells (SCs), the myelin-forming glia of the peripheral nervous system (PNS), are essential for nerve development and maintenance; however, the contribution of Ca2+ signaling to their maturation and long-term stability remains poorly understood ...
Jazmin G. Corral, Veronica T. Cheli, Diara A. Santiago-Gonzalez, Karishma G. Kedari, Pablo M. Paez   +4 more
doaj   +1 more source

Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific

, 2015
Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Graca, AB, Pearson, RA, Hippert, C, Barber, AC, West, EL, Smith, AJ, Ali, RR   +6 more
core  

Identification of midbrain floor plate radial glia-like cells as dopaminergic progenitors

, 2008
The floor plate (FP), a signaling center and a structure rich in radial glia-like cells, has been traditionally thought to be devoid of neurons and neuronal progenitors.
Bonilla Jiménez, Sonia, Bonilla, S., Bonilla, Sonia, Gotz, M., Pinto, L., Hall, A.C., Hall, A. C., Arenas, Ernest, Huttner, W.B., Wieland B. Huttner, Magdalena Götz, Gotz, Magdalena, Pinto, Luisa, Sonia Bonilla, Ernest Arenas, Luisa Pinto, Hall, Anita C, Anita C. Hall, Huttner, W. B., Huttner, Wieland B, Attardo, A., Huttner, W., Alessio Attardo, Hall, A., Arenas, E., Attardo, Alessio   +25 more
core   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Extracellular ATP/adenosine dynamics in the brain and its role in health and disease

Frontiers in Cell and Developmental Biology
Extracellular ATP and adenosine are neuromodulators that regulate numerous neuronal functions in the brain. Neuronal activity and brain insults such as ischemic and traumatic injury upregulate these neuromodulators, which exert their effects by ...
Eiji Shigetomi, Eiji Shigetomi, Kent Sakai, Kent Sakai, Schuichi Koizumi, Schuichi Koizumi   +5 more
doaj   +1 more source

Pax6, Tbr2, and Tbr1 Are Expressed Sequentially by Radial Glia, Intermediate Progenitor Cells, and Postmitotic Neurons in Developing Neocortex

Journal of Neuroscience, 2005
The developing neocortex contains two types of progenitor cells for glutamatergic, pyramidal-projection neurons. The first type, radial glia, produce neurons and glia, divide at the ventricular surface, and express Pax6, a homeodomain transcription ...
Chris Englund, Andy Fink, C. Lau, D. Pham, R. Daza, A. Bulfone, Tom Kowalczyk, R. Hevner   +7 more
semanticscholar   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Radial glia and somal translocation of radial neurons in the developing cerebral cortex

, 2003
A series of recent studies have demonstrated that radial glia are neural precursors in the developing cerebral cortex. These studies have further implied that these cells are the sole precursor constituents of the dorsal forebrain ventricular zone that ...
Ravishankar, Bagirathy, Nadarajah, Bagirathy   +1 more
core   +1 more source