Results 1 to 10 of about 32,728 (239)

The vascular effect of glibenclamide: A systematic review [PDF]

Cephalalgia Reports, 2019
Objective: To systematically review the vascular effects of glibenclamide. Background: Infusion of adenosine triphosphate (ATP)-sensitive potassium (K ATP ) channel opener (KCO) levcromakalim dilates cranial arteries and induces headache and migraine ...
Mohammad Al-Mahdi Al-Karagholi, Michael Sode, Aydin Gozalov, Messoud Ashina   +3 more
doaj   +2 more sources

Effect of experimental gestational diabetes and administration of glibenclamide on mRNA level of NLRP3-inflammasome and distribution of NLRP3+-cells in mesenteric lymph nodes in progeny

Patologìâ, 2017
A number of dysfunctions of congenital and adaptive components of the immune system are observed in progeny of rats with experimental gestational diabetes (EGD).
Т. М. Prozorova, V. A. Kamyshna, О. М. Kamyshnyi   +2 more
doaj   +3 more sources

Therapeutic Drug Monitoring, CYP2C9 Genotyping and Phenotyping in the Treatment of Diabetes with Glibenclamide Products

Регуляторные исследования и экспертиза лекарственных средств, 2020
Rational use of glybenclamide products in the treatment of patients with type 2 diabetes remains a high-priority task. The paper offers a summary of the main groups of glibenclamide drugs and describes pharmacogenetics of glybenclamide.
G. I. Gorodetskaya, V. V. Arkhipov, E. S. Melnikov, T. A. Rodina   +3 more
doaj   +3 more sources

Efficacy and safety of glibenclamide therapy after intracerebral haemorrhage (GATE-ICH): A multicentre, prospective, randomised, controlled, open-label, blinded-endpoint, phase 2 clinical trial

EClinicalMedicine, 2022
Summary: Background: Glibenclamide is a promising agent for treating brain oedema, but whether it improves clinical outcomes in patients with intracerebral haemorrhage (ICH) remains unclear.
Wen Jiang
exaly   +3 more sources

CO2 utilization as a gas antisolvent in the production of glibenclamide nanoparticles, glibenclamide-HPMC, and glibenclamide-PVP composites

Journal of CO2 Utilization
Glibenclamide is an antidiabetic drug that also acts as an anti-inflammatory factor and reduces oxidative stress, medullary edema, and heart attack. Glibenclamide has high permeability and poor solubility in water (BCS class II).
Seyed Ali Sajadian, Nadia Esfandiari, Luis Padrela   +2 more
exaly   +3 more sources

Engineered Glibenclamide-Loaded Nanovectors Hamper Inflammasome Activation in an Ex Vivo Alzheimer’s Disease Model—A Novel Potential Therapy for Neuroinflammation: A Pilot Study [PDF]

Biomolecules
Background: Inflammasomes regulate the activation of caspases resulting in inflammation; inflammasome activation is dysregulated in Alzheimer’s disease (AD) and plays a role in the pathogenesis of this condition. Glibenclamide, an anti-inflammatory drug,
Francesca La Rosa, Simone Agostini, Elisabetta Bolognesi, Ivana Marventano, Roberta Mancuso, Franca Rosa Guerini, Ambra Hernis, Lorenzo Agostino Citterio, Federica Piancone, Pietro Davide Trimarchi, Jorge Navarro, Federica Rossetto, Arianna Amenta, Pierfausto Seneci, Silvia Sesana, Francesca Re, Mario Clerici, Marina Saresella   +17 more
doaj   +2 more sources

A sensitive bioanalytical method for the simultaneous determination of amlodipine and glibenclamide [PDF]

Pharmaceutical Sciences Asia, 2022
Type 2 diabetes mellitus triggers hypertension as a complication. The use of amlodipine and glibenclamide drugs simultaneously results in a synergistic and effective lowering of blood sugar and blood pressure.
Febrina Amelia Saputri, Febrina Amelia Saputri, Aliya Nur Hasanah, Mutakin, Taofik Rusdiana, Ingrid Suryanti Surono, Rizky Abdulah, Rizky Abdulah   +7 more
doaj   +1 more source

Glibenclamide decreases ATP-induced intracellular calcium transient elevation via inhibiting reactive oxygen species and mitochondrial activity in macrophages. [PDF]

PLoS ONE, 2014
Increasing evidence has revealed that glibenclamide has a wide range of anti-inflammatory effects. However, it is unclear whether glibenclamide can affect the resting and adenosine triphosphate (ATP)-induced intracellular calcium ([Ca(2+)]i) handling in ...
Duo-ling Li, Zhi-yong Ma, Zhi-jie Fu, Ming-ying Ling, Chuan-zhu Yan, Yun Zhang   +5 more
doaj   +1 more source

Assessment of the effects of metformin and glibenclamide on the concentration of selected trace elements in type 2 diabetic patients [PDF]

Pharmacia, 2021
Metformin and glibenclamide may have beneficial effects on the levels of trace elements in diabetic patients. The aim of the current study was to assess the effects of metformin and glibenclamide on the concentrations of copper (Cu), zinc (Zn) and ...
Jehan A. Mohammad, Ammar A. Y. Almulathanon, Fatimah Haitham Fathi   +2 more
doaj   +3 more sources

Glibenclamide does not improve outcome following severe collagenase-induced intracerebral hemorrhage in rats.

PLoS ONE, 2021
Intracerebral hemorrhage (ICH) is a devastating insult with few effective treatments. Edema and raised intracranial pressure contribute to poor outcome after ICH.
Tiffany F C Kung, Cassandra M Wilkinson, Christine A Dirks, Glen C Jickling, Frederick Colbourne   +4 more
doaj   +1 more source