Results 21 to 30 of about 32,747 (256)

Enhancement of K+ conductance improves in vitro the contraction force of skeletal muscle in hypokalemic periodic paralysis [PDF]

open access: yes, 1990
An abnormal ratio between Na+ and K+ conductances seems to be the cause for the depolarization and paralysis of skeletal muscle in primary hypokalemic periodic paralysis.
Ballanyi   +19 more
core   +1 more source

Systemic Administration of Glibenclamide Fails to Achieve Therapeutic Levels in the Brain and Cerebrospinal Fluid of Rodents.

open access: yesPLoS ONE, 2015
Activating mutations in the Kir6.2 (KCNJ11) subunit of the ATP-sensitive potassium channel cause neonatal diabetes (ND). Patients with severe mutations also suffer from neurological complications.
Carolina Lahmann   +2 more
doaj   +1 more source

Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews [PDF]

open access: yes, 2018
Background Successful treatments for gestational diabetes mellitus (GDM) have the potential to improve health outcomes for women with GDM and their babies. Objectives To provide a comprehensive synthesis of evidence from Cochrane systematic reviews of
Alsweiler, Jane   +5 more
core   +1 more source

Glibenclamide Mimics Metabolic Effects of Metformin in H9c2 Cells

open access: yesCellular Physiology and Biochemistry, 2017
Background: Sulfonylureas, such as glibenclamide, are antidiabetic drugs that stimulate beta-cell insulin secretion by binding to the sulfonylureas receptors (SURs) of adenosine triphosphate-sensitive potassium channels (KATP).
Barbara Salani   +8 more
doaj   +1 more source

Temperature-dependent release of ATP from human erythrocytes: Mechanism for the control of local tissue perfusion [PDF]

open access: yes, 2012
Copyright @ 2012 The AuthorsThis article has been made available through the Brunel Open Access Publishing Fund.Human limb muscle and skin blood flow increases significantly with elevations in temperature, possibly through physiological processes that ...
Abraham   +58 more
core   +2 more sources

Gestational diabetes mellitus- right person, right treatment, right time? [PDF]

open access: yes, 2017
Background: Personalised treatment that is uniquely tailored to an individual’s phenotype has become a key goal of clinical and pharmaceutical development across many, particularly chronic, diseases.
Lindsay, Robert S.   +2 more
core   +1 more source

Cantu syndrome–associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms [PDF]

open access: yes, 2018
The complex disorder Cantu syndrome (CS) arises from gainof-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively. Recent reports indicate that such mutations
Grange, Dorothy K.   +7 more
core   +2 more sources

Glibenclamide-Induced Autophagy Inhibits Its Insulin Secretion-Improving Function in β Cells

open access: yesInternational Journal of Endocrinology, 2019
Diabetes is a metabolic disease, partly due to hypoinsulinism, which affects ∼8% of the world’s adult population. Glibenclamide is known to promote insulin secretion by targeting β cells.
Jiali Zhou   +6 more
doaj   +1 more source

Glibenclamide Alleviates LPS-Induced Acute Lung Injury through NLRP3 Inflammasome Signaling Pathway

open access: yesMediators of Inflammation, 2022
Glibenclamide displays an anti-inflammatory response in various pulmonary diseases, but its exact role in lipopolysaccharide- (LPS-) induced acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) remains unknown.
Jie Yang   +9 more
doaj   +1 more source

An overview of anti-diabetic plants used in Gabon: Pharmacology and Toxicology [PDF]

open access: yes, 2018
© 2017 Elsevier B.V. All rights reserved.Ethnopharmacological relevance: The management of diabetes mellitus management in African communities, especially in Gabon, is not well established as more than 60% of population rely on traditional treatments as ...
A. Souza   +374 more
core   +4 more sources

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