Results 31 to 40 of about 32,747 (256)
Assessment of in vivo and in vitro genotoxicity of glibenclamide in eukaryotic cells. [PDF]
PLoS ONE, 2015 Glibenclamide is an oral hypoglycemic drug commonly prescribed for the treatment of type 2 diabetes mellitus, whose anti-tumor activity has been recently described in several human cancer cells.
Juliane Rocha de Sant'Anna +3 more
doaj +1 more source
Metformin use in pregnancy: promises and uncertainties [PDF]
, 2017 Metformin has been prescribed in pregnancy for over 40 years; for much of this time, use has been limited both in numbers and geographically, and the evidence base has been confined to observational studies.
Lindsay, Robert S., Loeken, Mary R.
core +1 more source
Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells [PDF]
, 2017 ATP-sensitive potassium channels (K(ATP) channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K(ATP) channels are essential for coupling glucose metabolism to insulin secretion.
Conway, Hannah +8 more
core +2 more sources
The role of Volatile Anesthetics in Cardioprotection: a systematic review. [PDF]
, 2012 This review evaluates the mechanism of volatile anesthetics as cardioprotective agents in both clinical and laboratory research and furthermore assesses possible cardiac side effects upon usage.
Applegate, Richard L +5 more
core +1 more source
Journal of Experimental & Clinical Cancer Research, 2013 Background To observe the influence of combination treatment with glibenclamide and CoCl2 on the growth and invasiveness of TA2 breast cancer, and to detect the protein and mRNA expression of MMP9.
Zhe Rong +4 more
doaj +1 more source
Encapsulation and release characteristics of glibenclamide loaded calcium-alginate beads
Química Nova, 2010 The aims of this study were to formulate calcium-alginate beads containing glibenclamide, characterize the resulting microparticles, evaluate the release characteristics of this type of delivery system in an in vitro dissolution test, and compare it with
Dalia Charles-Navarro +8 more
doaj +1 more source
Is there NO treatment for severe sepsis? [PDF]
, 2008 Sepsis is a systemic inflammatory response syndrome in the presence of suspected or proven infection, and it may progress to or encompass organ failure (severe sepsis) and hypotension (septic shock).
Bredan, Amin, Cauwels, Anje
core +2 more sources
Journal of Pharmacological Sciences, 2004 The effects of orally administered dipeptidyl peptidase IV (DPP-IV) inhibitor on the glucose-lowering effect of glibenclamide are still unknown. We evaluated the effects of combination treatment with a long-lasting DPP-IV inhibitor, K579 ((S)-1-[4-methyl-
Kotaro Takasaki +4 more
doaj +1 more source
Hydrogen sulphide regulates inward-rectifying K+ channels in conjunction with stomatal closure [PDF]
, 2015 Hydrogen sulphide (H2S) is the third biological gasotransmitter and, in animals, affects many physiological processes by modulating ion channels. H2S has been reported to protect plants from oxidative stress in diverse physiological responses. H2S closes
Blatt, Mike R. +3 more
core +2 more sources
BMC Pregnancy and Childbirth, 2017 Background Metformin is widely used to treat gestational diabetes (GDM), but many women remain hyperglycaemic and require additional therapy. We aimed to determine recruitment rate and participant throughput in a randomised trial of glibenclamide ...
Rebecca M. Reynolds +12 more
doaj +1 more source