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Role of cytomegalovirus in glioblastoma development: promoter or culprit? [PDF]

Virology Journal
Glioblastoma is the most common primary malignant tumor of the central nervous system, with a median survival of less than two years. While the etiology of glioblastoma is unclear, viral infection has emerged as a potential contributing factor ...
Xiaoxin Wu, Zhengyu Zhang, Liang Zhang, David J Daniels   +3 more
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Cerebellar glioblastoma [PDF]

Cancer, 1982
Gene Kopelson
openalex   +4 more sources

Glioblastomas [PDF]

Cancers, 2021
Years ago, glioblastoma lost its second name, multiforme, which possibly was an unfortunate decision given the extraordinary heterogeneity of this overly aggressive primary brain tumor, as effectively exemplified by this Latin adjective [...]
Finocchiaro G., Berzero G.
openaire   +2 more sources

Electrotherapies for Glioblastoma [PDF]

Advanced Science, 2021
AbstractNon‐thermal, intermediate frequency (100–500 kHz) electrotherapies present a unique therapeutic strategy to treat malignant neoplasms. Here, pulsed electric fields (PEFs) which induce reversible or irreversible electroporation (IRE) and tumour‐treating fields (TTFs) are reviewed highlighting the foundations, advances, and considerations of each
Jenkins, E. P. W., Finch, A., Gerigk, M., Triantis, I., Watts, C., Malliaras, G. G.   +5 more
openaire   +5 more sources

High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

Frontiers in Oncology, 2021
Tumor heterogeneity is a key reason for therapeutic failure and tumor recurrence in glioblastoma (GBM). Our chimeric antigen receptor (CAR) T cell (2173 CAR T cells) clinical trial (NCT02209376) against epidermal growth factor receptor (EGFR) variant III
Radhika Thokala, Radhika Thokala, Zev A. Binder, Zev A. Binder, Yibo Yin, Yibo Yin, Logan Zhang, Logan Zhang, Jiasi Vicky Zhang, Jiasi Vicky Zhang, Daniel Y. Zhang, Daniel Y. Zhang, Michael C. Milone, Michael C. Milone, Guo-li Ming, Hongjun Song, Hongjun Song, Donald M. O’Rourke, Donald M. O’Rourke   +18 more
doaj   +1 more source

Glioblastoma and MiRNAs [PDF]

Cancers, 2021
Glioblastoma (GB) is one of the most common types of lethal brain tumors. Although several treatment options are available including surgery, along with adjuvant chemo and radiotherapy, the disease has a poor prognosis and patients generally die within 14 months of diagnosis. GB is chemo and radio resistant.
Swalih P. Ahmed, Javier S. Castresana, Mehdi H. Shahi   +2 more
openaire   +3 more sources

Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma

Frontiers in Oncology, 2021
Autologous chimeric antigen receptor (CAR) T cells targeted to epidermal growth factor receptor variant III (CAR T-EGFRvIII) have been developed and administered experimentally to treat patients with IDH1 wildtype recurrent glioblastoma (rGBM ...
Joseph S. Durgin, Joseph S. Durgin, Joseph S. Durgin, Fraser Henderson, MacLean P. Nasrallah, MacLean P. Nasrallah, Suyash Mohan, Sumei Wang, Simon F. Lacey, Jan Joseph Melenhorst, Jan Joseph Melenhorst, Jan Joseph Melenhorst, Arati S. Desai, Arati S. Desai, John Y. K. Lee, Marcela V. Maus, Carl H. June, Carl H. June, Steven Brem, Steven Brem, Roddy S. O’Connor, Roddy S. O’Connor, Zev Binder, Zev Binder, Donald M. O’Rourke, Donald M. O’Rourke   +25 more
doaj   +1 more source

Can ECIS Biosensor Technology Be Used to Measure the Cellular Responses of Glioblastoma Stem Cells?

Biosensors, 2021
Glioblastoma is considered the most aggressive and lethal form of brain cancer. Glioblastoma tumours are complex, comprising a spectrum of oncogenically transformed cells displaying distinct phenotypes.
Laverne Diana Robilliard, Jane Yu, Sung-Min Jun, Akshata Anchan, Graeme Finlay, Catherine E. Angel, Euan Scott Graham   +6 more
doaj   +1 more source

Radiated glioblastoma cell-derived exosomal circ_0012381 induce M2 polarization of microglia to promote the growth of glioblastoma by CCL2/CCR2 axis

Journal of Translational Medicine, 2022
Background Radiotherapy is the primary therapeutic option for glioblastoma. Some studies proved that radiotherapy increased the release of exosomes from cells.
Chunzhi Zhang, Yuan Zhou, Ya Gao, Ze Zhu, Xianliang Zeng, Weizi Liang, Songwei Sun, Xiuli Chen, Hu Wang   +8 more
doaj   +1 more source

Silencing of Histone Deacetylase 6 Decreases Cellular Malignancy and Contributes to Primary Cilium Restoration, Epithelial-to-Mesenchymal Transition Reversion, and Autophagy Inhibition in Glioblastoma Cell Lines

Biology, 2021
Glioblastoma multiforme, the most common type of malignant brain tumor as well as the most aggressive one, lacks an effective therapy. Glioblastoma presents overexpression of mesenchymal markers Snail, Slug, and N-Cadherin and of the autophagic marker ...
Alejandro Urdiciain, Elena Erausquin, María V. Zelaya, Idoya Zazpe, José L. Lanciego, Bárbara Meléndez, Juan A. Rey, Miguel A. Idoate, Natalia A. Riobo-Del Galdo, Javier S. Castresana   +9 more
doaj   +1 more source