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Glioblastomas [PDF]

Cancers, 2021
Years ago, glioblastoma lost its second name, multiforme, which possibly was an unfortunate decision given the extraordinary heterogeneity of this overly aggressive primary brain tumor, as effectively exemplified by this Latin adjective [...]
Finocchiaro G., Berzero G.
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High-Affinity Chimeric Antigen Receptor With Cross-Reactive scFv to Clinically Relevant EGFR Oncogenic Isoforms

Frontiers in Oncology, 2021
Tumor heterogeneity is a key reason for therapeutic failure and tumor recurrence in glioblastoma (GBM). Our chimeric antigen receptor (CAR) T cell (2173 CAR T cells) clinical trial (NCT02209376) against epidermal growth factor receptor (EGFR) variant III
Radhika Thokala, Radhika Thokala, Zev A. Binder, Zev A. Binder, Yibo Yin, Yibo Yin, Logan Zhang, Logan Zhang, Jiasi Vicky Zhang, Jiasi Vicky Zhang, Daniel Y. Zhang, Daniel Y. Zhang, Michael C. Milone, Michael C. Milone, Guo-li Ming, Hongjun Song, Hongjun Song, Donald M. O’Rourke, Donald M. O’Rourke   +18 more
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Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma

Frontiers in Oncology, 2021
Autologous chimeric antigen receptor (CAR) T cells targeted to epidermal growth factor receptor variant III (CAR T-EGFRvIII) have been developed and administered experimentally to treat patients with IDH1 wildtype recurrent glioblastoma (rGBM ...
Joseph S. Durgin, Joseph S. Durgin, Joseph S. Durgin, Fraser Henderson, MacLean P. Nasrallah, MacLean P. Nasrallah, Suyash Mohan, Sumei Wang, Simon F. Lacey, Jan Joseph Melenhorst, Jan Joseph Melenhorst, Jan Joseph Melenhorst, Arati S. Desai, Arati S. Desai, John Y. K. Lee, Marcela V. Maus, Carl H. June, Carl H. June, Steven Brem, Steven Brem, Roddy S. O’Connor, Roddy S. O’Connor, Zev Binder, Zev Binder, Donald M. O’Rourke, Donald M. O’Rourke   +25 more
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Zinc finger and SCAN domain-containing 18 suppresses the proliferation, self-renewal, and drug resistance of glioblastoma cells

Heliyon, 2023
Elucidation of cellular and molecular mechanisms key to glioblastoma growth, self-renewal, survival, and metastasis is important for developing novel therapeutic strategies.
Yan Wang, Jingwei Peng, Chenchen Song, Yining Yang, Tao Qin   +4 more
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Can ECIS Biosensor Technology Be Used to Measure the Cellular Responses of Glioblastoma Stem Cells?

Biosensors, 2021
Glioblastoma is considered the most aggressive and lethal form of brain cancer. Glioblastoma tumours are complex, comprising a spectrum of oncogenically transformed cells displaying distinct phenotypes.
Laverne Diana Robilliard, Jane Yu, Sung-Min Jun, Akshata Anchan, Graeme Finlay, Catherine E. Angel, Euan Scott Graham   +6 more
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Radiated glioblastoma cell-derived exosomal circ_0012381 induce M2 polarization of microglia to promote the growth of glioblastoma by CCL2/CCR2 axis

Journal of Translational Medicine, 2022
Background Radiotherapy is the primary therapeutic option for glioblastoma. Some studies proved that radiotherapy increased the release of exosomes from cells.
Chunzhi Zhang, Yuan Zhou, Ya Gao, Ze Zhu, Xianliang Zeng, Weizi Liang, Songwei Sun, Xiuli Chen, Hu Wang   +8 more
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Glioblastoma

Archives of Pathology & Laboratory Medicine, 2007
Abstract Context.—Glioblastoma (GBM), the most common primary intracranial malignancy, is a morphologically diverse neoplasm with dismal prognosis despite multimodality therapy. Only 3 distinct morphologic variants of GBM are currently recognized by the current World Health Organization classification scheme, including GBM, giant cell ...
C Ryan, Miller, Arie, Perry
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The adaptive transition of glioblastoma stem cells and its implications on treatments

Signal Transduction and Targeted Therapy, 2021
Glioblastoma is the most malignant tumor occurring in the human central nervous system with overall median survival time
Zeyu Wang, Hao Zhang, Shengchao Xu, Zhixiong Liu, Quan Cheng   +4 more
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Silencing of Histone Deacetylase 6 Decreases Cellular Malignancy and Contributes to Primary Cilium Restoration, Epithelial-to-Mesenchymal Transition Reversion, and Autophagy Inhibition in Glioblastoma Cell Lines

Biology, 2021
Glioblastoma multiforme, the most common type of malignant brain tumor as well as the most aggressive one, lacks an effective therapy. Glioblastoma presents overexpression of mesenchymal markers Snail, Slug, and N-Cadherin and of the autophagic marker ...
Alejandro Urdiciain, Elena Erausquin, María V. Zelaya, Idoya Zazpe, José L. Lanciego, Bárbara Meléndez, Juan A. Rey, Miguel A. Idoate, Natalia A. Riobo-Del Galdo, Javier S. Castresana   +9 more
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Role of Molecular Targeted Therapeutic Drugs in Treatment of Glioblastoma: A Review Article

Global Medical Genetics, 2023
Glioblastoma is remarkably periodic primary brain tumor, characterizing an eminently heterogeneous pattern of neoplasms that are utmost destructive and threatening cancers.
Himanshu Singh
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