Results 1 to 10 of about 540,674 (406)

ZDHHC15 promotes glioma malignancy and acts as a novel prognostic biomarker for patients with glioma

BMC Cancer, 2023
Background Glioma is the most common and aggressive tumor in the adult brain. Recent studies have indicated that Zinc finger DHHC-type palmitoyltransferases (ZDHHCs) play vital roles in regulating the progression of glioma.
Zhen-Yuan Liu, Tian Lan, Feng Tang, Yong-Ze He, Jin-Sheng Liu, Jin-Zhou Yang, Xi Chen, Ze-Fen Wang, Zhi-Qiang Li   +8 more
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PTPRZ1-MET FUsion GENe (ZM-FUGEN) trial: study protocol for a multicentric, randomized, open-label phase II/III trial

Chinese Neurosurgical Journal, 2023
Background PTPRZ1-MET fusion was reported to associate with glioma progression from low-grade to high-grade glioma, which was a target by a MET inhibitor vebreltinib.
Zhaoshi Bao, Shouwei Li, Liang Wang, Bisi Zhang, Peilong Zhang, Hepeng Shi, Xiaoguang Qiu, Tao Jiang   +7 more
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Clinical and Biological Significances of a Methyltransferase-Related Signature in Diffuse Glioma

Frontiers in Oncology, 2020
Methylation of DNA, RNA or protein is a reversible modification. The proteins and genes that regulate this modification can be a candidate target for tumor therapy. However, the characteristics of methyltransferase related genes in glioma remain obscure.
Ying Zhang, Ying Zhang, Yuqing Liu, Yuqing Liu, Hanjie Liu, Hanjie Liu, Zheng Zhao, Zheng Zhao, Fan Wu, Fan Wu, Fan Zeng, Fan Zeng   +11 more
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Immunological profiles of human oligodendrogliomas define two distinct molecular subtypesResearch in context

EBioMedicine, 2023
Summary: Background: Human oligodendroglioma presents as a heterogeneous disease, primarily characterized by the isocitrate dehydrogenase (IDH) mutation and 1p/19q co-deletion.
Fan Wu, Yi-Yun Yin, Wen-Hua Fan, You Zhai, Ming-Chen Yu, Di Wang, Chang-Qing Pan, Zheng Zhao, Guan-Zhang Li, Wei Zhang   +9 more
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TERT mutations-associated alterations in clinical characteristics, immune environment and therapy response in glioblastomas

Discover Oncology, 2023
Objective TERT is the most frequently mutated gene in adult glioblastomas (GBMs) defined by the 2021 World Health Organization classification system. The present study aims to explore differences in clinical characteristics and immune microenvironment ...
Feng Tang, Xi Chen, Jin-Sheng Liu, Zhen-Yuan Liu, Jin-Zhou Yang, Ze-Fen Wang, Zhi-Qiang Li   +6 more
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Palmitoyl transferases act as potential regulators of tumor-infiltrating immune cells and glioma progression

Molecular Therapy: Nucleic Acids, 2022
High immune-cell infiltration in glioblastomas (GBMs) leads to immunotherapy resistance. Emerging evidence has shown that zinc finger Asp-His-His-Cyc-type (ZDHHC) palmitoyl transferases participate in regulating tumor progression and the immune ...
Feng Tang, Chao Yang, Feng-Ping Li, Dong-Hu Yu, Zhi-Yong Pan, Ze-Fen Wang, Zhi-Qiang Li   +6 more
doaj   +1 more source

Characterization of tumor-associated reactive astrocytes in gliomas by single-cell and bulk tumor sequencing

Frontiers in Neurology, 2023
ObjectiveAstrocytes constitute approximately 30% of cells in gliomas and play important roles in synapse construction and survival. Recently, JAK/STAT pathway activation associated with a new type of astrocyte was reported.
Chuan-bao Zhang, Chuan-bao Zhang, Zhi-liang Wang, Zhi-liang Wang, Han-jie Liu, Han-jie Liu, Zheng Wang, Zheng Wang, Wang Jia, Wang Jia   +9 more
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Weighted correlation network analysis identifies multiple susceptibility loci for low‐grade glioma

Cancer Medicine, 2023
Background The current molecular classifications cannot completely explain the polarized malignant biological behavior of low‐grade gliomas (LGGs), especially for tumor recurrence.
Xiaodong Niu, Qi Pan, Qianwen Zhang, Xiang Wang, Yanhui Liu, Yu Li, Yuekang Zhang, Yuan Yang, Qing Mao   +8 more
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SAMD9 Is Relating With M2 Macrophage and Remarkable Malignancy Characters in Low-Grade Glioma

Frontiers in Immunology, 2021
Immunoreactions regulated by TAMs (Tumor-associated macrophages) play a pivotal role in tumorigenesis and metastasis. In recent decades, treatments based on immune regulation have achieved revolutionary breakthroughs in cancer targeted therapies.
Wenping Ma, Wenping Ma, Wenping Ma, Wenping Ma, Wenping Ma, Kenan Zhang, Zhaoshi Bao, Zhaoshi Bao, Tao Jiang, Tao Jiang, Tao Jiang, Tao Jiang, Tao Jiang, Ying Zhang, Ying Zhang   +14 more
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Systematic Analysis of a Pyroptosis-Related Signature to Predict the Prognosis and Immune Microenvironment of Lower-Grade Glioma

Cells, 2022
Current treatments for lower-grade glioma (LGG) do not effectively improve life expectancy rates, and this is a major global health concern. Improving our knowledge of this disease will ultimately help to improve prevention, accurate prognosis, and ...
Yongze He, Yuxiang Cai, Jinsheng Liu, Haixia Ding, Xiang Li, Sufang Tian, Zhiqiang Li   +6 more
doaj   +1 more source