Results 11 to 20 of about 437,642 (362)

Glioma [PDF]

Nature Reviews Disease Primers, 2015
Gliomas are primary brain tumours that are thought to derive from neuroglial stem or progenitor cells. On the basis of their histological appearance, they have been traditionally classified as astrocytic, oligodendroglial or ependymal tumours and assigned WHO grades I-IV, which indicate different degrees of malignancy.
Weller, Michael, Wick, Wolfgang, Aldape, Ken, Brada, Michael, Berger, Mitchell, Pfister, Stefan M, Nishikawa, Ryo, Rosenthal, Mark, Wen, Patrick Y, Stupp, Roger, Reifenberger, Guido   +10 more
openaire   +4 more sources

Predictive value of MGMT promoter methylation on the survival of TMZ treated IDH-mutant glioblastoma

Cancer Biology & Medicine, 2021
Objective: O6methylguanine-DNA methyltransferase (MGMT) promoter methylation is a biomarker widely used to predict the sensitivity of IDH-wildtype glioblastoma to temozolomide therapy.
Ruichao Chai, Guanzhang Li, Yuqing Liu, Kenan Zhang, Zheng Zhao, Fan Wu, Yuzhou Chang, Bo Pang, Jingjun Li, Yangfang Li, Tao Jiang, Yongzhi Wang   +11 more
doaj   +1 more source

Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas

BMC Cancer, 2020
Background Glioblastomas (GBM) are therapy-resistant tumors with a profoundly immunosuppressive tumor microenvironment. Chemotherapy has shown limited efficacy against GBM.
Julio Enríquez Pérez, Jan Kopecky, Edward Visse, Anna Darabi, Peter Siesjö   +4 more
doaj   +1 more source

Systematic Analysis of a Pyroptosis-Related Signature to Predict the Prognosis and Immune Microenvironment of Lower-Grade Glioma

Cells, 2022
Current treatments for lower-grade glioma (LGG) do not effectively improve life expectancy rates, and this is a major global health concern. Improving our knowledge of this disease will ultimately help to improve prevention, accurate prognosis, and ...
Yongze He, Yuxiang Cai, Jinsheng Liu, Haixia Ding, Xiang Li, Sufang Tian, Zhiqiang Li   +6 more
doaj   +1 more source

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]

, 2016
Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M, D'Alessandro, G, Di Angelantonio, S, Esposito, V, Esposito, V, Golia, MT, Grimaldi, A, Grössinger, EM, Limatola, C, Ragozzino, D, Santoro, A, Wulff, H   +11 more
core   +2 more sources

TMEFF2 promoter hypermethylation is an unfavorable prognostic marker in gliomas

Cancer Cell International, 2021
Background Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) is a transmembrane protein in the tomoregulin family. Little research has been performed to determine whether TMEFF2 methylation is a prognostic marker in adult ...
Sidi Xie, Yunxiao Zhang, Tao Peng, Jinglin Guo, Yongfu Cao, Jing Guo, Xiaofeng Shi, Yaqin Li, Yawei Liu, Songtao Qi, Hai Wang   +10 more
doaj   +1 more source

Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function [PDF]

, 2016
Background. Glioblastomas are the most aggressive type of brain tumor. A successful treatment should aim at halting tumor growth and protecting neuronal cells to prevent functional deficits and cognitive deterioration.
Ammassari-Teule, M, Baroncelli, L, Caleo, M, Costa, M, de Graaf, El, Fabbri, A, Fiorentini, C, Mcdonnell, L, Middei, S, Olimpico, F, Schmidt, G, Vannini, E   +11 more
core   +1 more source

CXCL16/CXCR6 axis drives microglia/macrophages phenotype in physiological conditions and plays a crucial role in glioma [PDF]

, 2018
Microglia are patrolling cells that sense changes in the brain microenvironment and respond acquiring distinct phenotypes that can be either beneficial or detrimental for brain homeostasis.
Antonangeli, Fabrizio, D'Alessandro, Giuseppina, Esposito, Vincenzo, Lepore, Francesca, Limatola, Cristina, Santoro, Antonio, Trettel, Flavia   +6 more
core   +1 more source

Comprehensive Analysis of Sterol O-Acyltransferase 1 as a Prognostic Biomarker and Its Association With Immune Infiltration in Glioma

Frontiers in Oncology, 2022
Metabolic reprogramming is a hallmark of glioma, and sterol O-acyltransferase 1 (SOAT1) is an essential target for metabolic therapy. However, the prognostic value of SOAT1 and its association with immune infiltration has not been fully elucidated. Using
Xuyang Guo, Xuyang Guo, Shaolong Zhou, Shaolong Zhou, Zhuo Yang, Zhuo Yang, Zi-An Li, Zi-An Li, Weihua Hu, Lirui Dai, Lirui Dai, Wulong Liang, Xinjun Wang, Xinjun Wang   +13 more
doaj   +1 more source

Children with 5′-end NF1 gene mutations are more likely to have glioma [PDF]

, 2017
Objective:To ascertain the relationship between the germline NF1 gene mutation and glioma development in patients with neurofibromatosis type 1 (NF1).Methods:The relationship between the type and location of the germline NF1 mutation and the presence of ...
Anastasaki, Corina, Gao, Feng, Gutmann, David H, Morris, Stephanie M   +3 more
core   +2 more sources