Results 11 to 20 of about 540,674 (406)
Nature Reviews Disease Primers, 2015 Gliomas are primary brain tumours that are thought to derive from neuroglial stem or progenitor cells. On the basis of their histological appearance, they have been traditionally classified as astrocytic, oligodendroglial or ependymal tumours and assigned WHO grades I-IV, which indicate different degrees of malignancy.
Weller, Michael +10 more
openaire +4 more sources
Glioma synapses recruit mechanisms of adaptive plasticity
Nature, 2023 The role of the nervous system in the regulation of cancer is increasingly appreciated. In gliomas, neuronal activity drives tumour progression through paracrine signalling factors such as neuroligin-3 and brain-derived neurotrophic factor^ 1 – 3 (BDNF),
Kathryn R. Taylor +28 more
semanticscholar +1 more source
Single-cell analysis of human glioma and immune cells identifies S100A4 as an immunotherapy target
Nature Communications, 2022 A major rate-limiting step in developing more effective immunotherapies for GBM is our inadequate understanding of the cellular complexity and the molecular heterogeneity of immune infiltrates in gliomas. Here, we report an integrated analysis of 201,986
Nourhan Abdelfattah +19 more
semanticscholar +1 more source
Molecular Cancer, 2022 Background Gliomas are the most common malignant primary brain tumours with a highly immunosuppressive tumour microenvironment (TME) and poor prognosis.
Z. Pan +21 more
semanticscholar +1 more source
Glioma targeted therapy: insight into future of molecular approaches
Molecular Cancer, 2022 Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically, gliomas occur among all ages, more often seen in adults, which males are more susceptible than females.
Keyang Yang +13 more
semanticscholar +1 more source
Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages
Nature Communications, 2021 Microglia are resident myeloid cells in the central nervous system (CNS) that control homeostasis and protect CNS from damage and infections. Microglia and peripheral myeloid cells accumulate and adapt tumor supporting roles in human glioblastomas that ...
Natalia Ochocka +7 more
semanticscholar +1 more source
Diffuse Glioma Heterogeneity and Its Therapeutic Implications.
Cancer Discovery, 2021 Diffuse gliomas represent a heterogeneous group of universally lethal brain tumors characterized by minimally effective genotype-targeted therapies.
James G Nicholson, H. Fine
semanticscholar +1 more source
Frontiers in Immunology, 2017 Neutrophils are the most abundant white blood cells and are the first recruited to inflammatory sites. Neutrophils are an important component of the tumor stroma and can exert both anti-tumoral and pro-tumoral activities, depending on their maturation and activation state.
Matteo Massara +12 more
openaire +5 more sources