Results 101 to 110 of about 4,610,729 (257)

Two Types of K⁺ Channel Subunit, Erg1 and KCNQ2/3, Contribute to the M-Like Current in a Mammalian Neuronal Cell [PDF]

, 1999
The potassium M current was originally identified in sympathetic ganglion cells, and analogous currents have been reported in some central neurons and also in some neural cell lines.
Abogadie, FC, Wood, IC, London, B, Buckley, NJ, Brown, DA, Hadley, JK, Delmas, P, Selyanko, AA   +7 more
core  

Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV

Advanced Science, EarlyView.
Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes, Daniel Simão, Stephan J. Holtkamp, Diana D. Lobo, Pradeep Harish, Rosalind Jenkins, Lekh N. Dahal, Rui J. Nobre, Luís de Pereira de Almeida, Mark Trautwein, Paula M. Alves, Catarina Brito   +14 more
wiley   +1 more source

FANCI is involved in the malignant progression of glioma cells by regulating the Akt/Bcl-2 signaling pathway

Discover Oncology
Introduction Fanconi anemia supplementation group I (FANCI), one of the Fanconi family proteins, may be closely related to the malignant progression of glioma cells.
Hanyun Li, Yinrui Liu, Mingyao Wang, Shaoshao Xu, Jilan Liu, Xianyun Qin, Banban Li, Jikui Sun, Yan Liu, Feng Jin   +9 more
doaj   +1 more source

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

Advanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale, Marie Celine Lefevre, Alessio Carmignani, Maria Cristina Ceccarelli, Matteo Battaglini, Attilio Marino, Gianni Ciofani   +6 more
wiley   +1 more source

Decrease in Ca2+-Activated K+ Conductance in Differentiated C6-Glioma Cells

, 2009
Ca2+-activated K+ channels were studied in C6-glioma cells in an attempt to correlate changes in expression with cell proliferation and differentiation. In this study, we treated C6-glioma cells with thapsigargin for 48 h. Cell proliferation was markedly
KUO, TSUN-CHENG;LIN-SHIAU, SHOEI-YN, 郭俊成;蕭水銀   +1 more
core  

5-Aminolevulinic acid-mediated sonosensitization of rat RG2 glioma cells in vitro

, 2016
Sonodynamic therapy (SDT) is a promising technique based on the ability of certain substances, called sonosensitizers, to sensitize cancer cells to non-thermal effects of low-energy ultrasound waves, allowing their destruction.
Krzysztof Bilmin, Wojciech Secomski, Tamara Kujawska, Andrzej Nowicki, Paweł Grieb   +4 more
core   +1 more source

Novel therapeutic venues for glioblastoma: novel rising preclinical treatment opportunities [PDF]

, 2011
High grade gliomas, including anaplastic glioma WHO grade III and glioblastoma WHO IV (GBM), carry a dismal prognosis. Taking all nowadays-available therapeutics options, including radiation, chemotherapy and surgery, for GBM into consideration the ...
Siegelin, Yasemin, Siegelin Yasemi, Siegelin, Markus David, Siegelin Markus David, Siegelin Yasemin, Siegelin Markus   +5 more
core   +1 more source

Improved effects of honokiol on temozolomide-induced autophagy and apoptosis of drug-sensitive and -tolerant glioma cells

BMC Cancer, 2018
Background Temozolomide (TMZ)-induced side effects and drug tolerance to human gliomas are still challenging issues now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houpo), is safe for normal brain ...
Chung-Ching Chio, Kung-Yen Chen, Cheng-Kuei Chang, Jian-Ying Chuang, Chih-Chung Liu, Shing-Hwa Liu, Ruei-Ming Chen   +6 more
doaj   +1 more source

Rapid In Vitro Pathological Diagnosis of Glioma Using Dual‐Color Quantum Dot Probes for Precise Intraoperative Resection

Advanced Science, EarlyView.
Glioma resection surgery is challenging because of the infiltrative growth of the tumor into nearby tissue and the different surgical requirements for gliomas with different mutation types. To improve the precision and effectiveness of glioma resection, this study developed a new imaging probe that enables the tumor boundary and mutation status to be ...
Dongdong Wu, Chenxuan Yang, Yuanbin Wu, Minghang Liu, Yizhi Zhang, Yuang Cai, Yibo Zhang, Jimei Chi, Hengchao Ma, Ding Zhang, Chenqing Liu, Meng Su, Guochen Sun   +12 more
wiley   +1 more source

Origin recognition complex 6 overexpression promotes growth of glioma cells

Cell Death and Disease
The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and underlying mechanisms associated with ORC6 (origin recognition complex 6) in glioma.
Wen-lei Yang, Wei-feng Zhang, Yin Wang, Yue Lou, Yu Cai, Jun Zhu   +5 more
doaj   +1 more source