Results 71 to 80 of about 79,800 (306)

A Combination of Two Human Monoclonal Antibodies Limits Fetal Damage by Zika Virus in Macaques [PDF]

, 2020
Human infection by Zika virus (ZIKV) during pregnancy can lead to vertical transmission and fetal aberrations, including microcephaly. Prophylactic administration of antibodies can diminish or prevent ZIKV infection in animal models, but whether passive ...
Agudelo, Marianna, Ardeshir, Amir, Balderes, Paul J., Bjorkman, Pamela J., Bournazos, Stylianos, Coffey, Lark L., Esswein, Shannon R., Gazumyanc, Anna, Immareddy, Ramya, Jurado, Andrea, Kapoor, Tania, Keeffe, Jennifer R., Keesler, Rebekah I., Lorenz, Ivo C., MacDonald, Margaret R., Nussenzweig, Michel C., Peace, Avery, Ravetch, Jeffrey V., Rice, Charles M., Robbiani, Davide F., Singapuri, Anil, Stuart, Jackson B., Usachenko, Jodie, Van Rompay, Koen K. A., Wang, Qiao, Watanabe, Jennifer   +25 more
core   +2 more sources

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Advanced Science, EarlyView.
A novel drug‐loaded D/P‐g‐PSB nanogel‐incorporated hydrogel by the electrostatic attraction‐driven self‐assembling process. Sequential drug releasing property (melatonin is released first by physical diffusion, and then ibuprofen is released as the charge shielding effect and hydrogel degradation). This ion‐sensitive hydrogel platform with sequentially
Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye   +13 more
wiley   +1 more source

In vivo Bioluminescence Imaging Used to Monitor Disease Activity and Therapeutic Response in a Mouse Model of Tauopathy

Frontiers in Aging Neuroscience, 2019
Many studies of tauopathy use transgenic mice that overexpress the P301S mutant form of tau. Neuronal damage in these mice is associated with astrogliosis and induction of glial fibrillary acidic protein (GFAP) expression.
Ambrose A. Dunn-Meynell, Ambrose A. Dunn-Meynell, Peter Dowling, Peter Dowling, Peter Dowling, Michelle Marchese, Esther Rodriguez, Benjamin Blumberg, Yun-Beom Choi, Yun-Beom Choi, Deeya Gaindh, Deeya Gaindh, Wei Lu   +12 more
doaj   +1 more source

PERAN PEMERIKSAAN MRI DTI DAN MT DALAM MENDETEKSI SKLEROSIS HIPOKAMPUS PADA EPILEPSI LOBUS TEMPORALIS MESIAL INTRAKTABEL DENGAN MRI NORMAL [PDF]

, 2015
Latar belakang : Etiologi Epilepsi Lobus Temporal Mesial (ELTM) intraktabel tersering adalah sklerosis hipokampus. Sekitar 20-30% pasien epilepsi fokal intraktabel menunjukkan MRI standar normal.MRI DTI dan MT, mempunyai kemampuan menunjukkan substrat ...
SUKMANINGTYAS, Hermina
core  

Neospora caninum and Bovine Neosporosis: Current Vaccine Research [PDF]

, 2017
Neospora caninum, a tissue cyst-forming parasite, is the causative agent of bovine neosporosis. It is considered to be one of the most important transmissible causes of reproductive failure in cattle; abortion and neonatal mortality result in significant
Marugan-Hernandez, V
core   +2 more sources

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Combined Diffusion Tensor Imaging and Quantitative Susceptibility Mapping Discern Discrete Facets of White Matter Pathology Post-injury in the Rodent Brain

Frontiers in Neurology, 2020
Early loss of white matter microstructure integrity is a significant cause of long-term neurological disorders following traumatic brain injury (TBI). White matter abnormalities typically involve axonal loss and demyelination.
Neha Soni, Viktor Vegh, Xuan Vinh To, Abdalla Z. Mohamed, Karin Borges, Fatima A. Nasrallah   +5 more
doaj   +1 more source

Brain abscess following rituximab infusion in a patient with pemphigus vulgaris. [PDF]

, 2015
BackgroundImmunocompromised patients are at increased risk for developing meningitis or, rarely, brain abscess with opportunistic organisms like Listeria monocytogenes.Case reportA 52 year-old Saudi Arabian woman who was diagnosed with pemphigus vulgaris
Al-Harbi, Talal M, Al-Muammar, Shahad A, Ellis, Ronald J   +2 more
core   +2 more sources

One-hundred years (and counting) of blast-associated traumatic brain injury [PDF]

, 2018
Blast-associated traumatic brain injury (TBI) has become one of the signature issues of modern warfare and is increasingly a concern in the civilian population due to a rise in terrorist attacks.
Fullerton, Josephine L., Kinch, Kevin, Stewart, William   +2 more
core   +1 more source

Assessing the Relative Importance of Imaging and Serum Biomarkers in Capturing Disability, Cognitive Impairment, and Clinical Progression in Multiple Sclerosis

Advanced Science, EarlyView.
Using machine‐learning analyses in two independent multiple sclerosis cohorts, spinal cord atrophy and cortical degeneration emerged as key predictors of disability and progression independent of relapses. Deep gray matter damage further improved prediction, while serum biomarkers of brain damage provided complementary information, highlighting the ...
Alessandro Cagol, Pascal Benkert, Sabine Schaedelin, Mario Ocampo‐Pineda, Noemi Montobbio, Po‐Jui Lu, Batuhan Ayci, Antonia Wenger, Alfi Aran Shukur, Kornelius Kaim, Lester Melie‐Garcia, Matthias Weigel, Alessio Signori, Pasquale Calabrese, Ludwig Kappos, Maria Pia Sormani, Jens Kuhle, Cristina Granziera   +17 more
wiley   +1 more source