Results 71 to 80 of about 58,440 (301)

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division

Frontiers in Neuroscience, 2020
A population of neural stem cells (NSCs) dwelling in the dentate gyrus (DG) is able to generate neurons throughout adult life in the hippocampus of most mammals. These NSCs generate also astrocytes naturally and are capable of generating oligodendrocytes
Roberto Valcárcel-Martín, Roberto Valcárcel-Martín, Soraya Martín-Suárez, Teresa Muro-García, Teresa Muro-García, Oier Pastor-Alonso, Oier Pastor-Alonso, Fernando Rodríguez de Fonseca, Guillermo Estivil-Torrús, Juan Manuel Encinas, Juan Manuel Encinas, Juan Manuel Encinas   +11 more
doaj   +1 more source

Gliosis difusa

, 2009
Cinco imágenes de una gliosis difusa.Five pictures of a diffuse ...
Iglesias Rozas, José Rafael, 1942-
core  

PolyG Fibrils Coalesce Into Nuclear Ribbons That Engage Proteostasis Machinery in Neuronal Intranuclear Inclusion Disease

Advanced Science, EarlyView.
In NIID, expanded NOTCH2NLC repeats give rise to nuclear polyG inclusions. Tracer‐guided in situ cryo‐electron tomography enables cross‐scale structural analysis from mouse brain to native neuronal nuclei, revealing dense‐core/peripheral‐halo inclusions built from compact polyG ribbons.
Hui Dong, Yongcheng Pan, Zhiyao Tang, Yuxuan Yao, Guicong Zhang, Junpu Wang, Haonan Xiao, Yun Tian, Beisha Tang, Dan Li, Qiang Guo, Ruijun Tian, Qiong Liu, Cong Liu   +13 more
wiley   +1 more source

Gliosis postmeningítica

, 2009
Dos imágenes de una gliosis postmeningítica en un niño.Two pictures of a gliosis after meningitis in a ...
Iglesias Rozas, José Rafael, 1942-
core  

A Robust Deep Temporal Causal Discovery Platform for Single‐Cell Gene Regulatory Network Reconstruction

Advanced Intelligent Discovery, EarlyView.
scTIGER2.0 is a deep‐learning framework that infers gene regulatory networks from single‐cell RNA sequencing data. By integrating correlation, pseudotime ordering, deep learning and bootstrap‐based significance testing, it reduces false positives and reveals directional gene interactions.
Nishi Gupta, Madison Dautle, Shaoqiang Zhang, Yong Chen   +3 more
wiley   +1 more source

Statins inhibit gliosis of MIO-M1, a Müller glial cell line, induced by TRPV4 activation

, 2022
Purpose: We characterized Müller cell gliosis induced by activation of transient receptor potential vanilloid-type 4 (TRPV4) and assessed whether statins could modulate the gliosis.
조윤혜
core   +1 more source

Conflicting MRI signals from gliosis and neuronal vacuolation in prion diseases

, 1999
Magnetic resonance imaging (MRI) has given inconsistent results when used as a non-invasive diagnostic tool for Creutzfeldt–Jakob disease (CJD). In order to understand this finding, we studied a hamster model of scrapie by in vivo MRI and histopathology.
Changani, K.K., Williams, S.C.R., Williams, A., Ritchie, D., Bell, J.D., Hope, J., Chung, Y.L.   +6 more
core  

Refining Domain‐Based Prognostication in DNM1 Encephalopathy: A Mild Phenotype Associated With a GTPase Domain Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT DNM1 encephalopathy is a rare autosomal dominant genetic condition characterized by a range of neurological and developmental manifestations. The typical phenotype is severe, including profound intellectual disability, treatment‐resistant epilepsy, ataxia, and structural brain abnormalities. However, milder presentations have increasingly been
Caroline Crain, Hope Northrup, Laura S. Farach, Sureni V. Mullegama, Kathleen Shields, Gretchen Von Allmen, Kate Richardson   +6 more
wiley   +1 more source

Idiopathic premacular gliosis in children and adolescents.

, 1989
We treated three patients under 20 years of age who had idiopathic premacular gliosis, a disorder found primarily in patients older than 50 years of age. Initial visual acuity ranged from 20/20 to 20/50, remained unchanged in one patient, improved in one
Blodi, C F, Wells, K K, Kimmel, A S, Weingeist, T A   +3 more
core   +1 more source